Strong linkage disequilibrium of HLA DPw11 with the HLA B44‐DR7‐DQw2 extended haplotype*

Bignon, Jean-Denis; Cheneau, M.L.; Herry, P.; Bonneville, Françoise; Cesbron, Anne; Muller, Jean‐Yves

doi:10.1111/j.1399-0039.1992.tb02154.x

Cited by 14 publications

(5 citation statements)

References 10 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Linkage disequilibrium was found between HLA-DPB1*1101 and HLA-DR7. This agrees with the findings of Bignon et al (40) and with those of Begovich et al (43), who suggest that HLA-DPB1*1101, HLA-DR7 and HLA-DQB1*0201 form an extended haplotype.…”

supporting

confidence: 93%

Comprehensive HLA‐DP typing using polymerase chain reaction with sequence‐specific primers and 95 sequence‐specific primer mixes

et al. 1998

View full text Add to dashboard Cite

HLA-DP is the third of the class II molecules. Its role is antigen presentation, and it has been suggested to play a part in the susceptibility to certain diseases such as berylliosis, sarcoidosis and juvenile chronic arthritis. The standard typing method is SSO typing, although other methods have been used. Probably the best is sequence-based typing, but this is time-consuming and requires expensive equipment. We describe a method for comprehensive HLA-DPB1 and HLA-DPA1 typing using sequence-specific primers. This method has the advantages that it is rapid - typing a single DNA sample takes under 3 hours - and does not require any special equipment or reagents. The method has been shown to be highly accurate by typing 60 cell line DNA samples in which there was 100% agreement between the types obtained and the published information. Similarly typing of 20 DNA samples previously typed by sequence-based typing gave 100% concordance. We used the method to type DNA samples from 102 UK Caucasoid kidney donors. The allele frequencies agree with previously published data. Linkage disequilibria between HLA-DPB1, HLA-DPA1 and the other class II antigens have been investigated. Strong linkage disequilibria exist between certain HLA-DPB1 and HLA-DPA1 alleles. This is unsurprising in view of their proximity on the chromosome. More unexpectedly, the data also suggest that genes further away along the chromosome are in linkage disequilibrium with HLA-DP, forming extended haplotypes.

show abstract

supporting

confidence: 93%

Comprehensive HLA‐DP typing using polymerase chain reaction with sequence‐specific primers and 95 sequence‐specific primer mixes

et al. 1998

View full text Add to dashboard Cite

show abstract

“…This haplotype was found at a similar frequency in French (4.6%), but in Germans, Belgians, Italians, Hungarians and Spaniards it has been found at lower frequencies (< 3.8%) ( Gregersen et al. , 1988 ; Bignon et al. , 1992 ).…”

Section: Resultsmentioning

confidence: 95%

Polymorphism of HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 haplotypes in a Croatian population

Grubić

unec

et al. 2000

European Journal of Immunogenetics

View full text Add to dashboard Cite

We describe for the first time extended haplotypes in a Croatian population. The present study gives the HLA-A, -B, -DRB1, -DQA1 and -DQB1 allele and haplotype frequencies in 105 families with at least two offspring. All individuals were studied by conventional serology for HLA class I antigens (A and B), while class II alleles (DRB1, DQA1, DQB1) were typed using the PCR-SSOP method. HLA genotyping was performed by segregation in all 105 families. For extended haplotype analysis, 420 independent parental haplotypes were included. Fourteen HLA-A, 18 HLA-B, 28 DRB1, 9 DQA1 and 11 DQB1 alleles were found in the studied population. Most of the DRB1 alleles in our population had an exclusive association with one specific DQA1-DQB1 combination. This strong linkage disequilibrium within the HLA class II region is often extended to the HLA-B locus. A total of 10 HLA-A, -B, -DRB1, -DQA1, -DQB1 haplotypes were observed with a frequency

show abstract

“…An interesting outcome of the present analysis was the demonstration that the DP-DR linkage disequilibrium that has been reported for several alleles (Matsui et al 1984;Bignon et al 1992;Tait et al 1992) became higher when the DR allele was considered to be a marker of a defined supratype (Table 3). This appeared to be the rule for all the DP-DR associations here described.…”

Section: Discussionmentioning

confidence: 74%

“…Significant associations were found between DP and DR alleles ( Table 3). Some of these have been described in Caucasoid populations, i.e., DPBI*OIO1 with DR3 and DPB1 *1101 and DPB1 "1701 with DR7 (Matsui et al 1984;Bignon et al 1992;Tait et al 1992). The association of DPB1 *1101 with the DR7.1 RFLP subtype and of DPBl*1701 with DR7.2/DQ2 are new.…”

Section: Frequency Of Inclusion Of B and Dr Alleles In Supratypes Inmentioning

confidence: 99%

HLA supratypes in an Italian population

et al. 1994

View full text Add to dashboard Cite

A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasoid populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.

show abstract

Strong linkage disequilibrium of HLA DPw11 with the HLA B44‐DR7‐DQw2 extended haplotype*

Abstract: J. D. Bignon, M. L. Cheneau, P. Herry, F. Bonneville, A. Cesbron, J. Y. Muller. Strong linkage disequilibrium of HLA DPw11 with the HLA B44‐DR7‐DQw2 extended haplotype. Tissue Antigens 1992: 39: 35‐37.

Cited by 14 publications

References 10 publications

Comprehensive HLA‐DP typing using polymerase chain reaction with sequence‐specific primers and 95 sequence‐specific primer mixes

Comprehensive HLA‐DP typing using polymerase chain reaction with sequence‐specific primers and 95 sequence‐specific primer mixes

Polymorphism of HLA‐A, ‐B, ‐DRB1, ‐DQA1 and ‐DQB1 haplotypes in a Croatian population

HLA supratypes in an Italian population

Contact Info

Product

Resources

About