Strong complement activation after acute ischemic stroke is associated with unfavorable outcomes

Széplaki, Gábor; Szegedi, Róbert; Hirschberg, Kristóf; Gombos, Tímea; Varga, Lilian; Karádi, István; Entz, László; Széplaki, Z; Garred, Peter; Prohászka, Zoltán; Füst, George

doi:10.1016/j.atherosclerosis.2008.07.044

Cited by 77 publications

(69 citation statements)

References 31 publications

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“…The S-Cr was 0.85± 0.27 mg/dL, and the eGFR was 79.1±23.3 mL/ tory cytokine or adipokine. It has been reported that serum levels of C3 may serve as a predictor of future coronary events [15][16][17] and also the clinical prognosis after acute ischemic stroke 18) . C3 production is enhanced by inflammation and metabolic disorders.…”

Section: Background Characteristics and Laboratory Data Of The Ckd Pamentioning

confidence: 99%

Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease

Kojima

Takei

Ogawa

et al. 2012

JAT

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Aim: Complement C3 (C3) is one of the major mediators of inflammation. Serum C3 has been shown to be correlated with the presence of atherosclerosis. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in patients with chronic kidney disease (CKD). Methods: Non-diabetic CKD (stages 1-3) patients who underwent renal biopsy were enrolled in this study. Renal arteriolosclerosis was defined by the presence of hyaline changes and vessel wall thickening in the renal biopsy specimens. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in CKD patients.

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Section: Background Characteristics and Laboratory Data Of The Ckd Pamentioning

confidence: 99%

Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease

Kojima

Takei

Ogawa

et al. 2012

JAT

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“…In atheromas, complement system elements such as various complement receptors, complement activation products, and regulatory proteins have been found 11,12 . C5 plays an important role in the immune cascade.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients

Weng

Zheng

et al. 2016

Arq. Neuro-Psiquiatr.

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The complement system has been confirmed to play an increasingly important role in ischemic stroke (IS). This study aimed to determine whether the single-nucleotide polymorphism of the complement 5 (C5) gene independently influences the occurrence, severity, and long-term outcome of IS in Chinese patients. Methods C5 rs17611 genetic variants were investigated in 494 IS patients and 330 control individuals .Ischemic stroke was classiﬁed into subtypes and patients were assessed 90 days post-stroke with the modified Rankin Scale to determine stroke outcome. Results The presence of C5 polymorphism was associated with the incidence of large artery atherosclerosis (LAA)-subtype IS (n =2 00; p = 0.031), which even persisted after adjustment for covariates (OR = 1.518; 95%CI = 1.093–2.018; p = 0.013). However, no association was found between genotypes and the severity and outcome of stroke (p = 0.978; p = 0.296). Conclusions The C5 polymorphism might contribute to the risk of LAA-subtype IS independently of other known risk predictors.

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“…A number of animal and human studies [29][30][31][32][33][34][35][36][37][38][39] , including our own [40][41][42] , demonstrated that activation of the complement system play a decisive role in the pathophysiology of IS. No study has reported data on functional state of FH and FL in this disorder.…”

Section: Discussionmentioning

confidence: 99%

Collectins, C3 complement protein, annexin V and C-reactive protein in acute ischemic stroke: interrelation and implication to upregulated apoptosis and inflammation

Boyajyan

Tsakanova

Sim

2014

Inflamm Cell Signal

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Upregulated inflammatory response and apoptosis, both triggered by ischemia, are the most destructive pathologic processes developed after acute ischemic stroke (IS) at both central and peripheral levels. Identification of molecular mediators of these processes and understanding of their pathomechanisms will support the development of therapies, which can significantly improve outcomes of IS-affected subjects.Mannan-binding lectin (MBL), ficolin L (FL), ficolin H (FH) and C3 complement proteins participate in apoptotic cells recognition and clearance through various mechanisms. In the present study we performed comparative determination of the blood levels of MBL, FL and FH, and hemolytic activity of C3 protein (C3H50) as well as apoptosis marker protein, circulating annexin V (cANXV), and inflammatory marker C-reactive protein (CRP) in 99 patients with acute IS on the first day of stroke onset and 110 healthy subjects. Potential correlation between all measured parameters was analyzed. Methods included enzyme-linked immunosorbent, hemolytic, and immunonephelometric assays; statistics were performed by Student's t-test and Pearson's correlation analysis. The obtained data demonstrated significantly increased and correlated with each other blood levels of MBL and C3H50, cANXV and CRP in patients compared to controls. Slight, while significant, changes in the blood levels of FL and FH were also observed. We concluded that post-ischemic response at the first day of IS onset is characterized by sufficiently elevated and positively correlated with each other blood levels of MBL, C3H50, cANXV and CRP as well as by slightly increased blood levels of FH and FL. The obtained results suggest that MBL and C3 protein are implicated in upregulated inflammatory response and apoptosis developed after IS onset at a peripheral level, and that these pathological processes are interrelated and interdependent.

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Strong complement activation after acute ischemic stroke is associated with unfavorable outcomes

Cited by 77 publications

References 31 publications

Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease

Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease

Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients

Collectins, C3 complement protein, annexin V and C-reactive protein in acute ischemic stroke: interrelation and implication to upregulated apoptosis and inflammation

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