Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease

Kojima, Chiari; Takei, Takashi; Ogawa, Tetsuya; Nitta, Kosaku

doi:10.5551/jat.12286

Cited by 11 publications

(3 citation statements)

References 44 publications

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“…On the other hand, it was reported that renal arteriolosclerosis was more commonly observed even in the absence of HT, particularly in IgA nephropathy compared with non-IgA nephropathy [34]. A possible explanation would be that renal arteriolosclerosis could be related to an immune-complex reaction and oxidative stress in glomerulonephritis [35,36]. Though we could not examine this relationship in the present study, the progression of arteriolosclerosis could be partially mediated by such factors other than HT.…”

Section: Discussioncontrasting

confidence: 51%

Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease

Kono

Fujii

Nakai

et al. 2016

Kidney Blood Press Res

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Background/Aims: Hypertension (HT) is a common complication in patients with chronic kidney disease (CKD). However, the relationship between circadian rhythm disorder of blood pressure (BP) and intra-renal damage remains unclear. Methods: Ninety patients with chronic glomerular disease (CGD) were included in the present study. On the basis of the clinic BP (CBP) and 24 h-ambulatory BP (ABP) measurements, the patients were divided into the following groups; normotension (NT), white coat HT (WHT), masked HT (MHT), and sustained HT (SHT). For renal histopathological assessment, we evaluated each biopsy specimen for sclerotic glomeruli (SG), interstitial fibrosis (IF), intimal thickening of intra-lobular arteries (ILA), and arteriolar hyalinosis (AH). Results: The prevalence of NT, WHT, MHT and SHT was 60.0%, 3.3%, 23.3%, and 13.4%, respectively. Compared with circadian BP pattern, all-day HT was most prevalent in the SHT group, whereas nighttime HT was most prevalent in the MHT group. The results of histological analysis showed that the SHT group had more severe SG and IF and the MHT group had more severe IF compared to the NT group. As for renal arteriolosclerosis, the MHT and SHT groups had more severe AH compared with the NT group, whereas ILA was comparable among all four groups. Furthermore, multivariate analysis revealed that ILA was significantly correlated only with age, whereas AH was significantly correlated with age and HT based on ABP, but not HT based on CBP. Conclusions: Our findings suggest that renal AH was severe not only in the SHT group, but also in the MHT group. Careful ABP monitoring should be recommended in patients with CGD.

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Section: Discussioncontrasting

confidence: 51%

Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease

Kono

Fujii

Nakai

et al. 2016

Kidney Blood Press Res

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“…HU has been found to independently predict the progression of kidney disease in diabetic nephropathy 46, 47) , IgA nephropathy 48–51) , chronic allograft nephropathy 52) , and CKD 45, 53, 54) . However, although HU has been associated with the presence of kidney arteriolar sclerosis 33, 50, 55, 56) in CKD patients, there is little evidence of an association between UA and disease progression of biopsy-proven nephrosclerosis. In animal models, HU has been found to induce systemic hypertension and afferent arteriolar sclerosis 57, 58) .…”

Section: Discussionmentioning

confidence: 99%

Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis

Momoki

Kataoka

Moriyama

et al. 2017

J Atheroscler Thromb

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Aim: The influence of serum urate on kidney disease is attracting attention, but the effects of uric acid (UA) on nephrosclerosis have not been elucidated.Methods: We reviewed data from 45 patients diagnosed with arterial/arteriolar nephrosclerosis. The renal outcomes of the arterial/arteriolar nephrosclerosis patients were assessed by performing logistic and Cox regression analyses. A Kaplan-Meier analysis was used to evaluate the impact of hyperuricemia (HU) on kidney survival. The renal outcomes of patients with and without HU were compared by using a propensity score-matched cohort.Results: The logistic regression models showed no significant differences in renal outcomes, according to baseline parameters or follow-up parameters, except the serum UA value and body mass index (BMI). Baseline serum UA level had the highest odds ratio (OR) for estimated glomerular filtration rate (eGFR) decline (OR, 1.86; 95% confidence interval (CI), 1.12 to 3.45), among the parameters assessed. In the multivariate Cox regression analysis, HU (UA ≥ 8.0 mg/dL) (P = 0.01) and BMI (P = 0.03) were significantly associated with a ≥ 50% eGFR decline or ESRD. The Kaplan-Meier analysis in the propensity score-matched cohort indicated that the renal survival rate of the group of arterial/arteriolar nephrosclerosis patients with HU was significantly lower than that of the group without HU (log rank, P = 0.03).Conclusion: The results of this study suggest that the baseline serum UA value can serve as a renal outcome predictor in arterial/arteriolar nephrosclerosis patients.

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“…Plasma C3, as partially originated from the kidney, could be a marker of ongoing injury of kidney cells, which ultimately results in CKD. Whereas no previous study has explored the association between circulating C3 and CKD in the general population, higher serum C3 levels have been found to be associated with higher levels of urine protein in patients with non-nephrotic CKD [28], and with renal arteriolosclerosis in patients with non-diabetic CKD [35]. Decreased blood C3 levels have been observed in some less common renal diseases (e.g.…”

Section: Discussionmentioning

confidence: 99%

Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study

et al. 2019

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Background Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we examined whether elevated C3 concentration is associated with hospitalization due to CKD in the general population, and whether this relationship is mediated by factors such as diabetes and hypertension. Methods Baseline plasma C3 was quantified in 4552 participants, without previous hospital admission due to CKD, from the Malmö Diet and Cancer cohort study. Incidence of first hospitalization due to CKD (main diagnosis) was investigated in relation to C3 levels using Cox proportional hazards regression models after a mean follow-up of 19.2 ± 4.16 years. Traditional risk factors of CKD including diabetes, blood pressure, C-reactive protein and baseline renal function were considered in adjustments and sensitivity analyses. Results During the follow-up period, 94 subjects were admitted to hospital due to CKD. After multivariate adjustment, the hazard ratios (95% confidence interval) for hospitalization from CKD across quartiles of C3 were 1.00 (reference), 1.68 (0.69, 4.13), 2.71 (1.15, 6.39), and 3.16 (1.36, 7.34) ( p for trend = 0.003). Results were generally consistent across different sensitivity analyses. Conclusions These findings indicate that C3 is associated with incidence of first hospitalization due to CKD in the general population. The observed relationship cannot be entirely attributed to hyperglycemia and hypertension.

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Serum Complement C3 Predicts Renal Arteriolosclerosis in Non-Diabetic Chronic Kidney Disease

Cited by 11 publications

References 44 publications

Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease

Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease

Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis

Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study

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