Strong association of the renin TaqI polymorphism with essential hypertension in Chinese Han and Tibetan populations

Haplotype-based association of the renin-angiotensin-aldosterone system genes polymorphisms with essential hypertension among Han Chinese: the Fangshan study

“…It has been proposed that to generate robust data, a much larger sample involving greater than 1000 subjects in each group might be required [24], and our sample sizes including 1089 cases and 926 controls can somewhat confirm our capacity to do this. Moreover, our study population represents an ethnically homogeneous one, which was purely made up of the Pekingese living a rurally-dominated and relatively-separated lifestyle in Beijing Fangshan district [14,15], which is the former residence of Peking Man, and study subjects were recruited following a population-based design and genotypes distributions of all studied polymorphisms that satisfied H-W equilibrium in the control group, which can lend support for the appropriate selection of the study population. This is, to the best of our knowledge, the largest case-control study to-date in China to explore the haplotype-based association of RAAS genes polymorphisms with essential hypertension.…”

“…The candidate genes and common polymorphisms selected in this study are founded on strong clinical, biological, genetic and epidemiological hints [9][10][11][12][13]. The Fangshan population offered some important advantages, including high prevalence of hypertension (16.8%), low prevalence of treatment, low divorce rate and limited mobility [14,15], which are invaluable for genetic association study.…”

Renin Gene Polymorphisms in Bangladeshi Hypertensive Population

“…Study with Chinese population revealed that hypertension is more strongly associated with Hind III polymorphisms of renin gene than Bgl I 18. Another study conducted among the rural residents of Beijing, China and urban Tibetan individuals confirmed that prevalence of hypertension is related to Taq I polymorphisms of 4063 bp upstream of renin gene promoter 19. Moreover, Mbo I dimorphism in intron 9 of the human renin gene is strongly associated with essential hypertension 20.…”

Correlation between angiotensinogen gene polymorphisms and essential hypertension in Chinese population

“…The genetic homogeneity and geographic stability of this population, along with high prevalence of hypertension (16.8%) and low prevalence of treatment, provide an excellent opportunity for studying the genetic influence on hypertension. 6 Our study was based on a door-to-door crosssectional design. Details of this study population have been published.…”

“…Details of this study population have been published. 6 Briefly, all subjects in this study are Han Chinese (pure pekingese) recruited from the Fangshan district in the southwest of Beijing. A total of 3045 subjects were recruited preliminarily, of whom we enrolled 1122 unrelated essential hypertensives with entry criteria as follows: (1) onset of age before 60 years; (2) mean systolic blood pressure (SBP) X140 mm Hg or mean diastolic blood pressure (DBP) X90 mm Hg; (3) free of secondary forms of hypertension through extensive clinical examination; (4) without any antihypertensive treatment.…”