2009
DOI: 10.1097/hjh.0b013e32832b7e0d
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Abstract: Taken together, we demonstrated three two-locus pairs of polymorphisms with synergistic effect out of three genes in RAAS and found significant haplotype-phenotype interaction. Functional studies to confirm or refute these findings are warranted.

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Cited by 70 publications
(86 citation statements)
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“…Although the authors have emphasized the cross-ethnic discrepancy in these associations, 9 most of their studies enrolled have produced negative results, especially in Asians. Similarly, negative findings regarding the association of C-344T with essential hypertension was also observed in our recent report from Northern Chinese (the Fangshan Study) 8 and from the present association study in Southern Chinese. Therefore, it is nothing to be surprised at the negative relevance of CYP11B2 C-344T polymorphism to its promoter activity in our experiment.…”
supporting
confidence: 88%
“…Although the authors have emphasized the cross-ethnic discrepancy in these associations, 9 most of their studies enrolled have produced negative results, especially in Asians. Similarly, negative findings regarding the association of C-344T with essential hypertension was also observed in our recent report from Northern Chinese (the Fangshan Study) 8 and from the present association study in Southern Chinese. Therefore, it is nothing to be surprised at the negative relevance of CYP11B2 C-344T polymorphism to its promoter activity in our experiment.…”
supporting
confidence: 88%
“…In our study, no association with hypertension was observed for the ACE I/D polymorphism although it has been linked with hypertension [24][25][26][27][28] and ACE levels. 8,20,29 However, after being a focus of research Abbreviations: AIC, Akaike information criterion; BMI, body mass index; OR, odds ratio; 95% CI, 95% confidence interval.…”
Section: Discussioncontrasting
confidence: 80%
“…[5][6][7] In addition, because of the population heterogeneity of genetic background, it is essential to construct a database of polymorphisms related to hypertension in each racial or ethnic group. 8 To fully address this issue and to minimise genetic background noise, we centred on Chinese populations and meta-analysed the association of MTHFR C677T polymorphism with hypertension and HIP, while addressing heterogeneity, as well as publication bias.…”
Section: Introductionmentioning
confidence: 99%