Strong Antibacterial Effect of Miswak Against Oral Microorganisms Associated With Periodontitis and Caries

Sofrata, Abier Hamed; Claesson, Rolf; Lingström, Peter; Gustafsson, Anders

doi:10.1902/jop.2008.070506

Cited by 121 publications

(82 citation statements)

References 20 publications

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“…For inhibition of oral pathogens, many plant extracts have been reported to have the potential on this purpose, for example, ethyl acetate extract of Camellia sinensis leaves was reported to decrease the incidence of dental caries (23) whereas water extract of Vaccinium macrocarpon fruits showed an inhibitory effect against protease enzyme of Porphyromonas gingivalis (24). Moreover, the extract from Salvadora persica stem can inhibit many oral pathogenic bacteria, such as S. mutans, Lactobacillus acidophilus, Aggregatibacter actinomycetemcomitans, and P. gingivalis (25). Present study was done on P. betle, a plant widely grown in Southeast Asian countries.…”

Section: Discussionmentioning

confidence: 99%

Potential of <i>Piper betle</i> extracts on inhibition of oral pathogens

Phumat

Khongkhunthian

Wanachantararak

et al. 2017

DD&T

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Section: Discussionmentioning

confidence: 99%

Potential of <i>Piper betle</i> extracts on inhibition of oral pathogens

Phumat

Khongkhunthian

Wanachantararak

et al. 2017

DD&T

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“…Salvadora persica), is a small tree or shrub with a crooked trunk. It is reported to exhibit antiulcer (Monforte et al, 2001), anticonvulsant (Monforte et al, 2002), analgesic (Mansour et al, 1996), antibacterial (Al-Ali & Al-Lafi, 2003;Sofrata et al, 2008), antiinflammatory (Al-Hindwai et al, 1989) and antioxidant activities (Dhankhar et al, 2012). It contains a number of medically beneficial properties including abrasives, astringents and antiseptics.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antihyperlipidemic and antitumor activities of isolated coumarins fromSalvadora indica

Iyer¹,

Patil²

2013

Pharmaceutical Biology

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Context: Salvadora indica Wight (Salvadoraceae) contains a number of medically beneficial properties including abrasives, astringents and antiseptics. Traditionally, it was used by ancient Arabs to whiten and polish teeth. Objective: This study explores the antihyperlipidemic and antitumor effects of an ethanol extract of S. indica and its isolated phytoconstituents in rodents. Material and methods: Flash chromatography was used for the isolation of phytoconstituents from the stems of S. indica. An antihyperlipidemic study was carried out in Triton loaded rats. Animal groups were given intraperitoneal (i.p.) injection of Triton WR 1339 at dose of 400 mg/ kg body weight (b.w.). Furthermore, antitumor activity was investigated in hybrid mice (of C57BL strain þ Swiss albino strain). The animals were observed for tumor growth after injection of B16F10 melanoma cells into the dorsal skin of mice. Results: The stems of S. indica yielded xanthotoxin and umbelliferone through chromatographic separation techniques. The structures of the compounds were elucidated by spectroscopic data interpretation and showed antihyperlipidemic activity. The study showed significant reduction in total cholesterol (TC) (p50.01), triglycerides (TGs) (p50.001), low-density lipoproteins (p50.01) level whereas increased in high-density lipoprotein (p50.01) at a significant level, after the treatment. Pretreatment with the extract and phytoconstituents also showed delayed tumor growth by increasing the volume doubling time (VDT) (p50.01), growth delay (GD) (p50.01) and mean survival time (p50.001). Discussion and conclusion: Acute treatment caused a stimulatory effect on high density lipoprotein level and inhibition in TC and TG elevation induced by Triton. Tumor regression studies showed a regression response for tumor growth in vivo of murine mouse melanoma as demonstrated by increasing the VDT and GD.

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“…The use of miswak which is a tooth cleaning twig is a socially recognized dental cleaning method prevailing in Saudi Arabia and has been reported to result in significant reductions in plaque [38,39]. A study conducted in 10 regions of Saudi Arabia based on 3117 persons fifteen years and older revealed that half the population studied used miswak for their dental cleaning [40].…”

Section: Oral Hygiene Practicesmentioning

confidence: 99%

“…Generally a large part of the society follows the use of miswak. The use of miswak among young Saudis seems to cut across social, economic and regional lines with multiple studies confirming acceptance of this habit [29,[38][39][40][41]. Children are often influenced by their teachers and studies have shown that between two third and a fifth of all school teachers surveyed used only miswak (Figure 3) to maintain oral hygiene [42].…”

Section: Oral Hygiene Practicesmentioning

confidence: 99%

Dietary and Geographic and Cultural Factors as Predictors of Dental Caries Risk among Children in Saudi Arabia ? A Systematic Review

Pani¹

2015

Primary Health Care

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The widespread prevalence of dental caries in Saudi Arabia has been a cause for concern. As the largest country in the Middle East region and with a population of over 20 million, geographic and socio demographic challenges play a role in understanding caries risk in the country. The aim of this systematic review was to use the PRISMA guidelines to conduct a systematic review of the dietary, geographic and socio demographic factors that could influence the prevalence of dental caries in Saudi Arabia. A review of the MEDLINE, Pubmed Central, Google Scholar and EBSCO databases revealed 47 relevant articles. This review discusses the through the findings of the above mentioned articles the dietary, geographic and socio demographic factors that could influence the prevalence of dental caries in children in Saudi Arabia.

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Strong Antibacterial Effect of Miswak Against Oral Microorganisms Associated With Periodontitis and Caries

Abstract: Miswak embedded in agar or suspended above the agar plate had strong antibacterial effects against all bacteria tested. The antibacterial effect of suspended miswak pieces suggests the presence of volatile active antibacterial compounds.

Cited by 121 publications

References 20 publications

Potential of <i>Piper betle</i> extracts on inhibition of oral pathogens

Potential of <i>Piper betle</i> extracts on inhibition of oral pathogens

Evaluation of antihyperlipidemic and antitumor activities of isolated coumarins fromSalvadora indica

Dietary and Geographic and Cultural Factors as Predictors of Dental Caries Risk among Children in Saudi Arabia ? A Systematic Review

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