Strong and frequent T‐cell responses to the minor allergen Phl p 12 in Spanish patients IgE‐sensitized to Profilins

Abstract

The strength, prevalence and cross-reactivity of T-cell responses towards Phl p 12 are comparable to the major allergen Phl p 1, which supports the hypothesis that T cells to Phl p 12 can play an important role in development of allergic symptoms, such as those associated with pollen-food syndrome.

Profilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling

“…36 Recently, profilin has been demonstrated to induce a similar T-cell response to major pollen allergens in profilin-sensitized patients. 37 These data strengthen the clinical relevance of profilin sensitization and its importance in disease progression. Therefore daily exposure to profilin, which is present in all vegetables, could contribute to maintaining the inflammatory allergy phenotype, even in the absence of immediate relations.…”

Allergen Immunotherapy in Children User’s Guide

“…In the last decades, a progressive increase in profilin prevalence among pediatric patients has been reported . Interestingly, clinical reactivity to profilin is a good model to understand how differential exposure levels to pollens may lead to a diversity of clinical phenotypes, with effect in T‐cell reactivity, barrier disruption, and systemic biomarker signatures . We need to understand how these differences in allergen exposure levels affect pediatric patients, and how early intervention may stop disease progression to severe phenotypes later in life.…”

Multi‐omics analysis points to altered platelet functions in severe food‐associated respiratory allergy

“…In fact, some grass pollen‐allergic patients resident in highly exposed regions can develop severe food allergic reactions mediated by profilin, a type of reaction hardly seen in other grass pollen‐exposed territories. Profilin has proved to be a clinically relevant aeroallergen able to induce strong T‐cell proliferation . Recently, it has been proved that evolution toward severity in the profilin food allergy model is associated with a progressive rise in effector cell sensitivity, immune cells infiltration in the epithelia, and structural remodeling of the oral mucosa .…”