Stromelysin Promoter 5A/6A Polymorphism Is Associated With Acute Myocardial Infarction

Terashima, Masahiro; Akita, Hozuka; Kanazawa, Kenji; Inoue, N.; Yamada, Shinichiro; Ito, Keiichi; Matsuda, Yasuaki; Takai, Eiji; Iwai, Chikao; Kohno, Hiroyuki; Yoshida, Yutaka; Yokoyama, Mitsuhiro

doi:10.1161/01.cir.99.21.2717

Cited by 158 publications

(100 citation statements)

References 9 publications

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“…Three functional polymorphisms of MMPs are known to be related to coronary artery disease, i.e., MMP-3, MMP-9, and MMP-12 (Ye et al 1995;Terashima et al 1999;Zhang et al 1999;Jormsjo et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

et al. 2002

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The matrix metalloproteinases appear to play an important role in the development and progression of atherosclerotic lesions. We studied the C-1562T polymorphism of the gelatinase B promoter in relation to coronary artery disease and restenosis after a percutaneous coronary intervention (PCI) in Koreans. To determine the frequency of the C-1562T allele, we examined 63 patients with coronary artery disease who underwent both PCI and 6-month follow-up coronary angiograms (CAGs), and 67 control patients with a normal CAG with respect to their clinical data and genotype. Frequencies of the C/C homozygotes and the non-C/C heterozygotes and homozygotes (C/T and T/T) were 94% and 6% in the normal CAG group, and 76.2% and 23.8% in the patient group, respectively. This gave a relative risk of 0.203 (95% CI: 0.063-0.651, P ϭ 0.005) for coronary artery disease when the C/C genotype was compared with the non-C/C genotype. In the patient groups, the allele frequencies of the C/C and non-C/C were 80% and 20% in the nonrestenotic subgroup, and 71.4% and 28.6% in the restenotic subgroup (P ϭ 0.554). No T/T homozygote was found in any of the groups. We conclude that C/C homozygosity is a potential genetic protective factor for coronary artery disease in Koreans.

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Section: Introductionmentioning

confidence: 99%

Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

et al. 2002

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“…Association of 5A allele with MI were reported in Japanese populations (14,15), in young (45 years) Han-Chinese patients from Taiwan (16), in Han-Chinese patients from China (17) and in Caucasians (18). However a genome wide association study looking at 112 polymorphisms in 71 candidate genes in 4152 Japanese people found an association between the 6A allele and MI, although this was confined to women (19).…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase-3 (MMP-3) -1612 5A/6A promoter polymorphism in coronary artery disease in Indian population

Shalia

Shah

Mashru

et al. 2010

Indian J Clin Biochem

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“…These polymorphisms have been studied in several diseases including ovarian and colorectal cancer, myocardial infarction, aortic aneurysm and coronary atherosclerosis [19]. The MMP-3 5A/6A polymorphism, which has either five or six consecutive adenosine bases, has been associated with high blood pressure [21], acute myocardial infarction [22], aortic stiffening [23] and has been shown as independent predictor of cardiac mortality in patients with non-ischaemic cardiomyopathy [24]. In the present study, we investigated whether polymorphic variations in the promoter of MMP-1 and MMP-3 genes predict the adaptive response to mitral regurgitation in patients with MVP.…”

Section: Discussionmentioning

confidence: 99%

Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients

Oceandy

Yusoff

Baudoin

et al. 2007

European J of Heart Fail

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Background and aims: Mitral valve prolapse (MVP) is common and highly variable in its severity, but the factors underlying this variability are unclear. In this study, we tested the hypothesis that polymorphic variations in Matrix Metalloproteinase (MMP) genes might be predictors of left ventricular (LV) remodelling and severity of regurgitation in MVP. Methods and results: 70 MVP patients and 75 normal subjects were studied. We performed comprehensive echocardiography and analyzed promoter polymorphisms in the MMP-1 and MMP-3 genes. The MMP-3 -1612 5A/6A polymorphism showed strong associations with indices of mitral regurgitation and LV remodelling: Patients with 5A/5A allele had more pronounced remodelling and more severe mitral regurgitation than patients with the 6A/6A or 5A/6A alleles. We then cloned and sequenced 2 kb fragments of MMP-3 promoter from patients with 5A/5A and 6A/6A genotypes and found 4 different sets of promoter haplotypes. Promoter analysis showed that higher promoter activity was related to a more severe phenotype and that the haplotype variants had a more dominant role in determining the activity. Conclusions: Our data identifies the MMP-3 promoter haplotype as a novel marker of an adverse disease course in MVP, suggesting the presence of genetic determinants for the severity of MVP.

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Stromelysin Promoter 5A/6A Polymorphism Is Associated With Acute Myocardial Infarction

Abstract: The 5A/6A polymorphism in the promoter of the stromelysin gene is a novel pathogenetic risk factor for AMI.

Cited by 158 publications

References 9 publications

Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

Matrix metalloproteinase-3 (MMP-3) -1612 5A/6A promoter polymorphism in coronary artery disease in Indian population

Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients

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