Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

Cho, Hyun‐Jai; Chae, In‐Ho; Park, Kyung Woo; Ju, Jae-Ran; Oh, Seil; Lee, Hae Young; Park, Young-Bae

doi:10.1007/s100380200006

Cited by 36 publications

(25 citation statements)

References 11 publications

(17 reference statements)

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“…However, when the studies of Cho et al [30] and Horne et al [7] were excluded, the Egger test did not suggest the presence of a publication bias (p = 0.1696) (online suppl. fig.…”

Section: Resultsmentioning

confidence: 99%

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Meta-Analysis of MMP9 –1562C/T and the Risk of Coronary Heart Disease

Lü²,

Feng³

et al. 2013

Cardiology

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Introduction: Previous case-control studies have suggested that the –1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene (MMP9) are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis. Methods: Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed. Results: The meta-analysis of the –1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The –1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08–1.45, p = 0.004). There was heterogeneity among the 12 studies (I² = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16). Conclusions: The synthesis of available evidence supports the fact that the MMP9 –1562C/T polymorphism is a risk factor for CHD.

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“…However, when the studies of Cho et al [30] and Horne et al [7] were excluded, the Egger test did not suggest the presence of a publication bias (p = 0.1696) (online suppl. fig.…”

Section: Resultsmentioning

confidence: 99%

“…For the –1562C/T polymorphism, according to the inclusion criteria, a total of 14 studies from 14 articles were identified [3,4,5,7,8,13,20,22,23,30,31,32,33,34]. A list of the relevant details abstracted from these studies was provided (online suppl.…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of MMP9 –1562C/T and the Risk of Coronary Heart Disease

Lü²,

Feng³

et al. 2013

Cardiology

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“…1). Finally, 16 papers (Pollanen et al, 2001;Wang J. et al, 2001;Cho et al, 2002;Kim et al, 2002;Morgan et al, 2003;Haberbosch and Gardemann, 2005;Nuzzo et al, 2006;Horne et al, 2007;Nanni et al, 2007;Koh et al, 2008;Alp et al, 2009;Fallah et al, 2010;Ghaderian et al, 2010;Zhi et al, 2010;Opstad et al, 2012;Wang L. et al, 2012) were included in our meta-analysis involving 11 032 CAD patients and 4628 non-CAD controls. We divided the included studies into three sections according to ethnicities: Western populations, East Asians, and West Asians.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The MMP-9 gene has three major polymorphisms in the promoter, coding and untranslated regions (Zhang et al, 1999b). Of these, the C1562T (rs3918242) polymorphism (C→T) in the promoter region is of special interest, for many studies have found a close association between C1562T polymorphism and CAD (Cho et al, 2002;Morgan et al, 2003;Koh et al, 2008;Zhi et al, 2010). However, some other studies (Haberbosch and Gardemann, 2005;Alp et al, 2009) did not found such a close relationship.…”

Section: Introductionmentioning

confidence: 99%

Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis

Wang

Shi

2014

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Many investigations have studied the associations between matrix metalloproteinase-9 (MMP-9) C1562T polymorphisms and coronary artery disease (CAD). However, the conclusions of these studies were inconsistent. Therefore, this study was aimed at clarifying the association between MMP-9 C1562T polymorphisms and CAD in a large-scale meta-analysis. Methods: The PubMed and Embase databases were retrieved to collect all publications on the association between MMP-9 C1562T polymorphisms and CAD. Then the odd ratios (ORs) and 95% confidence intervals (95% CIs) for C1562T TT+TC versus CC genotype between CAD and the control groups were evaluated. Subgroup analysis was also performed according to different races. The meta-analysis was performed by Stata 10.0. Results: Sixteen case-control studies were included in our meta-analysis, involving 11 032 CAD patients and 4628 non-CAD controls. Compared with C allele carriers, East Asian T allele carriers TT+TC had a significantly higher risk of CAD (OR=1.43; 95% CI: 1.03-1.99; P=0.031); however, there were no significant associations in Western populations (OR=1.06; 95% CI: 0.96-1.18; P=0.240) or West Asians (OR=1.13; 95% CI: 0.75-1.70; P=0.565). When further analyzing the association between C1562T polymorphisms and myocardial infarction (MI, the most serious type of CAD), the risk of TT+TC genotype versus CC genotype for MI was significantly higher for the overall (OR=1.21; 95% CI: 1.04-1.40; P=0.012) and for East Asians (OR=1.58; 95% CI: 1.26-1.97; P=0.000) but not in Western populations (OR=1.12; 95% CI: 0.99-1.26; P=0.078). Conclusions: Our meta-analysis suggested an obvious ethnic difference in the association between MMP-9 C1562T polymorphisms and CAD. MMP-9 C1562T polymorphism was significantly related to CAD in East Asians. However, no significant associations were observed in either West Asians or Western populations.

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“…Nevertheless, this variant was extensively and repeatedly studied in CAD. Both positive [120,121] and negative [122,123] association of −1562T allele with the disease were presented. The metaanalysis of previous studies showed no association of MMP-9-1562 C/T polymorphism with coronary heart disease [113].…”

Section: Mmp-9mentioning

confidence: 99%

Overview of MMP Biology and Gene Associations in Human Diseases

Djurić¹,

Živković²

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Interactions of cell with the extracellular matrix (ECM) are crucial for normal development and functioning of the human organism. By regulating ECM integrity and composition matrix metalloproteinases (MMPs) play the main role in ECM molecules signaling and influence processes such as proliferation, migration, differentiation and apoptosis.ECM remodeling is a highly regulated process. When imbalanced it could contribute to pathophysiology of many diseases. The MMPs actions and activity are regulated through different mechanisms such as regulation of transcription, activation of latent MMPs, inhibition of MMP function by tissue inhibitors of metalloproteinases. MMPs are a family of calcium-and zinc-dependent endoproteinase, which share similar structural domains, but differs in substrate specificity, cell localizations and inducibility. Genetic variations in MMPs have been associated with a number of diseases, still not all findings are reproducible. Nine of 23 human genes encoding MMPs are located in a cluster on chromosome 11, which implicate their haplotype-driven effects. They could be important mediators of disease severity and could trigger acute events. In this chapter, we will review the basics of MMP biology and the most significant associations of MMPs variations with cardiovascular and neurological diseases in humans and MMPs therapeutic potential through synthetic inhibitors.

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Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

Cited by 36 publications

References 11 publications

Meta-Analysis of <b><i>MMP9</i></b> –1562C/T and the Risk of Coronary Heart Disease

Meta-Analysis of <b><i>MMP9</i></b> –1562C/T and the Risk of Coronary Heart Disease

Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis

Overview of MMP Biology and Gene Associations in Human Diseases

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