STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Sachdev, Perminder S.; Lo, Jessica; Crawford, John D.; Mellon, Lisa; Hickey, Anne; Williams, David; Bordet, Régis; Mendyk, Anne‐Marie; Gelé, Patrick; Deplanque, Dominique; Bae, Hee‐Joon; Lim, Jae‐Sung; Brodtmann, Amy; Werden, Emilio; Cumming, Toby; Köhler, Sebastian; Verhey, Frans R.J.; Dong, Yanhong; Tan, Hui Shan; Chen, Christopher; Xu, Xiaoyan; Kalaria, Rajesh N.; Allan, Louise; Akinyemi, Rufus; Ogunniyi, Adesola; Klimkowicz‐Mrowiec, Aleksandra; Dichgans, Martin; Wollenweber, Frank Arne; Zietemann, Vera; Hoffmann, Michael; Desmond, David W.; Lindén, Thomas; Blomstrand, Christian; Fagerberg, Björn; Skoog, Ingmar; Godefroy, Olivier; Barbay, Mélanie; Roussel, Martine; Lee, Byung‐Chul; Yu, Kyung‐Ho; Wardlaw, Joanna M.; Makin, Stephen; Doubal, Fergus; Chappell, Francesca M; Srikanth, Velandai; Thrift, Amanda G.; Donnan, Geoffrey A.; Kandiah, Nagaendran; Chander, Russell J.; Lin, Xuling; Cordonnier, Charlotte; Moulin, Solène; Rossi, Costanza; Sabayan, Behnam; Stott, David J.; Jukema, J Wouter; Melkas, Susanna; Jokinen, Hanna; Erkinjuntti, Timo; Mok, Vincent; Wong, Adrian; Lam, Bonnie Yin Ka; Leys, Didier; Hénon, Hilde; Bombois, Stéphanie; Lipnicki, Darren M.; Kochan, Nicole A.

doi:10.1016/j.dadm.2016.10.006

Cited by 47 publications

(54 citation statements)

References 62 publications

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“…56 For this, longitudinal studies are needed that study this temporal relationship in both directions. 57,58 Another possibility may be that both are caused by a third unknown factor.…”

Section: Etiology and Predictors Of Psdmentioning

confidence: 99%

“…This harmonization provides the opportunity to 219 conduct large individual patient data meta-analyses, which have several advantages over standard meta-analyses that only use published results. 56 Therefore, CASPER joined the STROKOG consortium (https://cheba.unsw.edu.au/group/strokog), 57 which has built a database with more than 12,000 stroke patients already and will likely yield important results concerning factors associated with PSD and PSA. This will hopefully result in potential targets for treatment and prevention of these syndromes, which is another urgent area for future research.…”

Section: Recommendations For Future Researchmentioning

confidence: 99%

“…In addition, there should not be any interference in daily activities and no diagnosis of dementia according to DSM-5 criteria. 57 The impairments have to represent a significant decline from premorbid levels of functioning. The diagnosis and type of dementia is made by an experienced neuropsychiatrist or neuropsychologist based on DSM-5 criteria.…”

Section: Neuropsychological Assessment and Cognitive Endpointsmentioning

confidence: 99%

“…Thirty-nine cohorts (30%) were followed prospectively. Some studies used semi-structured psychiatric interviews like the Mini International Neuropsychiatric Interview, 57 or the Structured Clinical Interview for DSM disorders, 58 based on Diagnostic and Statistical Manual of Mental Disorders (DSM) version III 59 or IV, 60 whereas others 30 used clinician-rated or self-rated questionnaires (e.g. the Hamilton Depression Rating Scale, 61 Montgomery-Åsberg Depression Rating Scale, 62 or the Geriatric Depression Scale 63 to evaluate the presence of PSD, and different cut-offs were applied.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The diagnosis and type of dementia is made by an experienced neuropsychiatrist or neuropsychologist based on DSM-5 criteria. 57 A consensus meeting is arranged when there is a discrepancy in diagnosis, and if no consensus can be reached, the patient will be considered not demented. The diagnosis of AD is made according to the standardized clinical criteria for AD based on the National Institute for Neurological and Communicative…”

Section: Neuropsychological Assessment and Cognitive Endpointsmentioning

confidence: 99%

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Depression and apathy after stroke

Douven¹

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“…56 For this, longitudinal studies are needed that study this temporal relationship in both directions. 57,58 Another possibility may be that both are caused by a third unknown factor.…”

Section: Etiology and Predictors Of Psdmentioning

confidence: 99%

Section: Recommendations For Future Researchmentioning

confidence: 99%

Section: Neuropsychological Assessment and Cognitive Endpointsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Neuropsychological Assessment and Cognitive Endpointsmentioning

confidence: 99%

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Depression and apathy after stroke

Douven¹

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Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Sexton

Anstey

Baldacci

et al. 2021

Alzheimer's & Dementia

Self Cite

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The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms underlying vascular contributions to cognitive impairment and dementia; and through the Women's Healthy Aging Project have elucidated hormonal and other factors that contribute to the increased risk of AD in women. Alleviating the behavioral and psychological symptoms of dementia has also been a strong research and clinical focus in Australia.

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Testing a convolutional neural network‐based hippocampal segmentation method in a stroke population

Zavaliangos‐Petropulu

Tubi²,

Haddad³

et al. 2020

Human Brain Mapping

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As stroke mortality rates decrease, there has been a surge of effort to study poststroke dementia (PSD) to improve long-term quality of life for stroke survivors. Hippocampal volume may be an important neuroimaging biomarker in poststroke dementia, as it has been associated with many other forms of dementia. However, studying hippocampal volume using MRI requires hippocampal segmentation.Advances in automated segmentation methods have allowed for studying the hippocampus on a large scale, which is important for robust results in the heterogeneous stroke population. However, most of these automated methods use a single atlasbased approach and may fail in the presence of severe structural abnormalities common in stroke. Hippodeep, a new convolutional neural network-based hippocampal segmentation method, does not rely solely on a single atlas-based approach and thus may be better suited for stroke populations. Here, we compared quality control and the accuracy of segmentations generated by Hippodeep and two well-accepted hippocampal segmentation methods on stroke MRIs (FreeSurfer 6.0 whole hippocampus and FreeSurfer 6.0 sum of hippocampal subfields). Quality control was performed using a stringent protocol for visual inspection of the segmentations, and accuracy was measured as volumetric correlation with manual segmentations. Hippodeep performed significantly better than both FreeSurfer methods in terms of quality control.All three automated segmentation methods had good correlation with manual segmentations and no one method was significantly more correlated than the others.Overall, this study suggests that both Hippodeep and FreeSurfer may be useful for hippocampal segmentation in stroke rehabilitation research, but Hippodeep may be more robust to stroke lesion anatomy.

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STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Cited by 47 publications

References 62 publications

Depression and apathy after stroke

Depression and apathy after stroke

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Testing a convolutional neural network‐based hippocampal segmentation method in a stroke population

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