Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Sexton, Claire E.; Anstey, Kaarin J.; Baldacci, Filippo; Barnum, Christopher J.; Barron, Anna M.; Blennow, Kaj; Brodaty, Henry; Burnham, Samantha; Elahi, Fanny M.; Götz, Jürgen; Jeon, Yun‐Hee; Koronyo‐Hamaoui, Maya; Landau, Susan; Lautenschlager, Nicola T.; Laws, Simon M.; Lipnicki, Darren M.; Lu, Hanzhang; Masters, Colin L.; Moyle, Wendy; Nakamura, Akinori; Pasinetti, Giulio Maria; Rao, Naren P.; Rowe, Christopher C.; Sachdev, Perminder S.; Schofield, Peter R.; Sigurdsson, Einar M.; Smith, Kate; Srikanth, Velandai; Szoeke, Cassandra; Tansey, Malú G.; Whitmer, Rachel A.; Wilcock, Donna M.; Wong, Tien Yin; Bain, Lisa J.; Carrillo, María C.

doi:10.1002/alz.12380

Cited by 6 publications

(4 citation statements)

References 167 publications

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“…Increased age and vascular risk factors, including diabetes, hypertension, alcohol, smoking, Myocardial infarction, and stroke, are known to increase the risk of AD [18,19]. Low socioeconomic status is associated with cognitive decline [18], low education level and ethnicity are the risk factor for AD [20,21]. In addition, woman is also associated with higher AD risk [22].…”

Section: Study Populationmentioning

confidence: 99%

Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study

Yuan

Yang

et al. 2022

BMC Geriatr

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Background Alzheimer's disease (AD) is the most frequently occurring type of dementia. Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably, genetic and environmental factors are now considered contributors to AD progression. Objective To assess the association between sleep duration, genetic susceptibility, and AD. Methods and results Based on 483,507 participants from the UK Biobank (UKB) with an average follow-up of 11.3 years, there was a non-linear relationship between AD incidence and sleep duration (P for non-linear < 0.001) by restricted cubic splines (RCS). Sleep duration was categorized into short sleep duration (< 6 h/night), normal sleep duration (6–9 h/night), and long sleep duration (> 9 h/night). No statistically significant interaction was identified between sleep duration and the AD-GRS (Alzheimer's disease genetic risk score, P for interaction = 0.45) using Cox proportional risk model. Compared with the participants who had a low AD-GRS and normal sleep duration, there was associated with a higher risk of AD in participants with a low AD-GRS and long sleep duration (HR = 3.4806; 95% CI 2.0011–6.054, p < 0.001), participants with an intermediate AD-GRS and long sleep duration (HR = 2.0485; 95% CI 1.3491–3.1105, p < 0.001), participants with a high AD-GRS and normal sleep duration (HR = 1.9272; 95% CI 1.5361–2.4176, p < 0.001), and participants with a high AD-GRS and long sleep duration (HR = 5.4548; 95% CI 3.1367–9.4863, p < 0.001).In addition, there was no causal association between AD and sleep duration using Two Sample Mendelian randomization (MR). Conclusion In the UKB population, though there was no causal association between AD and sleep duration analyzed using Two Sample MR, long sleep duration (> 9 h/night) was significantly associated with a higher risk of AD, regardless of high, intermediate or low AD-GRS. Prolonged sleep duration may be one of the clinical predictors of a higher risk of AD.

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Section: Study Populationmentioning

confidence: 99%

Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study

Yuan

Yang

et al. 2022

BMC Geriatr

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“…The Dementia Prevention and Risk Management Program for Aboriginal Australians (DAMPAA) study is a targeted, culturally appropriate, Aboriginal Health Practitioner (AHP)‐coordinated, risk‐factor management program. DAMPAA aims to reduce cognitive decline and functional impairment in Aboriginal Australians aged 45 years and over at risk of dementia, and evaluate its effectiveness through an RCT 30 …”

Section: Introductionmentioning

confidence: 99%

“…DAMPAA aims to reduce cognitive decline and functional impairment in Aboriginal Australians aged 45 years and over at risk of dementia, and evaluate its effectiveness through an RCT. 30 …”

Section: Introductionmentioning

confidence: 99%

Co‐design of dementia prevention program for Aboriginal Australians (DAMPAA)

Mateo‐Arriero

Lalovic

Dowden

et al. 2023

Alzheimer's & Dementia

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IntroductionDementia is highly prevalent in older Aboriginal Australians, with several modifiable risk factors. Currently, there is limited evidence on how to prevent cognitive decline in Aboriginal Australians.MethodsBased on our Theory of Change (ToC) framework, we co‐developed the Dementia risk management and prevention program for Aboriginal Australians (DAMPAA) aged over 45 years in partnership with Aboriginal community‐controlled organizations (ACCOs) and Elders. Qualitative data were collected through ACCO staff workshops, Elders yarning, and governance groups to inform the protocol. Additionally, we conducted a small pilot study.ResultsExpected DAMPAA ToC outcomes are: (1) improved daily function, (2) better cardiovascular risk management, (3) falls reduction, (4) improved quality of life, and (5) reduced cognitive decline. Attendance enablers are social interaction, environment, exercise type/level, and logistics.DiscussionFindings suggest that ToC is an effective collaborative approach for co‐designing Aboriginal health programs.

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“…With the aging of population, dementia has become a major public concern worldwide and is expected to affect 1.5 million people by 2050, placing an enormous burden on society [ 1 , 2 ]. Current drug treatments for dementia, especially Alzheimer's disease (AD), have not yielded satisfactory results [ 3 ]. More and more risk factors for dementia have been identified by evidence-based medicine, which has promoted the development of dementia prevention strategies [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Associations of screen-based sedentary activities with all cause dementia, Alzheimer’s disease, vascular dementia: a longitudinal study based on 462,524 participants from the UK Biobank

Yuan,

Li,

Ling

et al. 2023

BMC Public Health

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Background Current drug treatments for dementia aren't effective. Studying gene-environment interactions can help develop personalized early intervention strategies for Alzheimer's disease (AD). However, no studies have examined the relationship between screen-based sedentary activities and genetic susceptibility to AD risk, and further understanding of the causal relationship is also crucial. Methods This study included 462,524 participants from the UK Biobank with a follow-up of 13.6 years. Participants' screen-based sedentary activities time was categorized into three groups based on recorded time: ≥ 4 h/day, 2–3 h/day, and ≤ 1 h/day. Cox proportional risk models were used to analyze the association between computer use/TV viewing groups and the risk of all-cause dementia, AD and vascular dementia (VD). Generalized linear model (GLM) were used to examine the relationship between screen-based sedentary activities and brain structure. Bidirectional Mendelian randomization (MR) was used to validate the causal relationship between TV viewing and AD. Results Compared to TV viewing ≤ 1 h/day, 1)TV viewing 2–3 h/day was correlated with a higher risk of all-cause dementia (HR = 1.09, 95% CI:1.01–1.18, P < 0.05), and TV viewing ≥ 4 h/day was associated with a higher risk of all-cause dementia (HR = 1.29, 95% CI: 1.19–1.40, P < 0.001), AD (HR = 1.25, 95% CI:1.1–1.42, P < 0.001), and VD (HR = 1.24, 95% CI: 1.04–1.49, P < 0.05); 2) TV viewing ≥ 4 h/day was correlated with a higher AD risk at intermediate (HR = 1.34, 95% CI: 1.03–1.75, P < 0.001) and high AD genetic risk score (AD-GRS) (HR = 2.18, 95% CI: 1.65–2.87, P < 0.001);3) TV viewing 2–3 h/day [β = (-94.8), 95% CI: (-37.9) -(-151.7), P < 0.01] and TV viewing ≥ 4 h/day [β = (-92.94), 95% CI: (-17.42) -(-168.46), P < 0.05] were correlated with a less hippocampus volume. In addition, a causal effect of TV viewing times was observed on AD analyzed using MR Egger (OR = 5.618, 95%CI:1.502–21.013, P < 0.05). Conclusions There was a causal effect between TV viewing time and AD analyzed using bidirectional MR, and more TV viewing time exposure was correlated with a higher AD risk. Therefore, it is recommended that people with intermediate and high AD-GRS should control their TV viewing time to be less than 4 h/ day or even less than 1 h/day.

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Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Cited by 6 publications

References 167 publications

Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study

Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study

Co‐design of dementia prevention program for Aboriginal Australians (DAMPAA)

Associations of screen-based sedentary activities with all cause dementia, Alzheimer’s disease, vascular dementia: a longitudinal study based on 462,524 participants from the UK Biobank

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