Stroke preventing effect of resveratrol isolated from fungi and in vivo activity in male albino rats

Abdel-Hadi, Ahmed; Aloyuni, Saleh Abdullah; Alharbi, Raed; Jahan, Sadaf; Darwish, Omar; Senthilkumar, Subramanian; Palanisamy, Manikanadan; Ismail, Ahmed

doi:10.1016/j.jksus.2022.102074

Cited by 2 publications

(2 citation statements)

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“…Interestingly, the accumulation of resveratrol inside the MG1 strain was initiated at the early stage of the exponential phase contradicting the previous reports in which most of the secondary metabolites are accumulated at the late stage ( Chomcheon et al, 2009 ; Kornsakulkarn et al, 2011 ). Among thirteen endophytic fungal isolates belonging to Penicillium , Alternaria , and Aspergillus obtained from different parts of the Brinjal plant ( Solanum melongena ), Alternaria alternata was the highest resveratrol producer (206 μg/L) ( Abdel-Hadi et al, 2022 ). Whereas, resveratrol is not detected in the Brinjal plant ( Singh et al, 2016 ).…”

Section: Resveratrol-producing Entophytic Fungimentioning

confidence: 99%

Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes

et al. 2022

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Resveratrol (3,4,5-trihydroxystilbene) is a naturally occurring polyphenolic stilbene compound produced by certain plant species in response to biotic and abiotic factors. Resveratrol has sparked a lot of interest due to its unique structure and approved therapeutic properties for the prevention and treatment of many diseases such as neurological disease, cardiovascular disease, diabetes, inflammation, cancer, and Alzheimer’s disease. Over the last few decades, many studies have focused on the production of resveratrol from various natural sources and the optimization of large-scale production. Endophytic fungi isolated from various types of grapevines and Polygonum cuspidatum, the primary plant sources of resveratrol, demonstrated intriguing resveratrol-producing ability. Due to the increasing demand for resveratrol, one active area of research is the use of endophytic fungi and metabolic engineering techniques for resveratrol’s large-scale production. The current review addresses an overview of endophytic fungi as a source for production, as well as biosynthesis pathways and relevant genes incorporated in resveratrol biosynthesis. Various approaches for optimizing resveratrol production from endophytic fungi, as well as their bio-transformation and bio-degradation, are explained in detail.

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Section: Resveratrol-producing Entophytic Fungimentioning

confidence: 99%

Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes

et al. 2022

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“…The microorganisms used for RES production are mainly endophytic fungi. In one study, 13 endophytic fungal isolates were examined and Alternaria alternata was found to produce 206 μg/L of RES with the highest yield ( 7 ). In contrast, chemical synthesis methods require strict conditions and precise control, which renders them more commonly used in laboratory synthesis ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Multidimensional biological activities of resveratrol and its prospects and challenges in the health field

Yu,

Jia,

Ren

2024

Front. Nutr.

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Resveratrol (RES) is a naturally occurring polyphenolic compound. Recent studies have identified multiple potential health benefits of RES, including antioxidant, anti-inflammatory, anti-obesity, anticancer, anti-diabetic, cardiovascular, and neuroprotective properties. The objective of this review is to summarize and analyze the studies on the biological activities of RES in disease prevention and treatment, as well as its metabolism and bioavailability. It also discusses the challenges in its clinical application and future research directions. RES exhibits significant potential in the prevention and treatment of many diseases. The future direction of RES research should focus on improving its bioavailability, conducting more clinical trials to determine its effectiveness in humans, and investigating its mechanism of action. Once these challenges have been overcome, RES is expected to become an effective health intervention.

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Stroke preventing effect of resveratrol isolated from fungi and in vivo activity in male albino rats

Cited by 2 publications

References 33 publications

Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes

Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes

Multidimensional biological activities of resveratrol and its prospects and challenges in the health field

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