Stroke or coronary artery disease prediction from mean platelet volume in patients with type 2 diabetes mellitus

Abstract

The aim of this study was to determine the association of mean platelet volume (MPV) with the development of stroke or coronary artery disease (CAD) in diabetes mellitus (DM). MPV was analyzed in 200 Korean patients with DM. The primary endpoint was composite of ischemic stroke/CAD events. The mean MPV was 7.6 ± 0.8 fl. There were 14 ischemic stroke events and 8 CAD events during a mean of 28.4 months of follow-up. The Kaplan-Meier analysis revealed that the higher tertile MPV group (≥7.9 fl) had a significantly higher stroke/CAD rate compared to the lower tertile MPV group (≤7.3 fl) (29.9% vs. 2.8%, log-rank: p< 0.001). Higher MPV was an independent predictor of stroke/CAD risk after adjusting for 10-year risk ≥10%, hypertension, dyslipidemia, and previous stroke or transient ischemic attack history (hazard ratio: 11.92, 95% confidence interval 2.68-52.92, p = 0.001) in the Cox proportional hazard analysis. When the MPV cut-off level was set to 7.95 fl using the receiver operating characteristic curve, the sensitivity was 91% and the specificity was 80% for differentiating between the group with stroke/CAD and the group without stroke/CAD. This value was more useful in patients with hypertension. The results of this study show that MPV is a predictive marker for stroke/CAD; its predictive power for stroke/CAD is independent of age, gender, hypertension, and hemoglobin A1C.

Liver enzymes, mean platelet volume, and red cell distribution width in gestational diabetes

“…Numerous studies have firmly established a link between MPV, which indicates platelet size, and DM (9,10,23,24). According to the National Health and Nutrition Examination Survey study, participants with DM and poor glycemic control had significantly higher MPV values than healthy controls (24).…”

Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c

“…It can be determined by routine automated hemograms at a relatively low cost [22]. An increased of MPV is one of the risk factors for micro vascular and macro vascular complications, including cardiovascular disease (CVD), retinopathy, nephropathy occur due to chronic un control hyperglycemia in diabetics also myocardial infarction, ischemic stroke and venous thromboembolism [23][24][25][26][27][28][29].…”

An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome

“…Moreover, it has been reported that an increase in platelet volume occurs with acute MI, acute cerebral ischemia, and transient ischemic attacks. [22] Futhermore, Han et al [23] reported that MPV is a predictive marker for stroke or CAD, and Greisenegger et al [24] determined that an elevated MPV is associated with a poorer outcome for acute ischemic cerebrovascular events independent of other clinical parameters. Previous studies have also reported that high MPV levels are related with cardiovascular risk [25] and that these levels increase in patients with cardiac conditions [26][27][28] who have a poor prognosis.…”