Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy

Ovbiagele, Bruce; Nguyen‐Huynh, Mai N.

doi:10.1007/s13311-011-0053-1

Cited by 339 publications

(254 citation statements)

References 86 publications

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“…Infections complicating the acute phase of stroke occur in up to 30% of patients, with pneumonia and urinary tract infections accounting for up to 10% each (Westendorp et al 2011). Pneumonia increases the risk of death three-six fold (Katzan et al 2003;Ovbiagele and Nguyen-Huynh 2011) and likelihood of worse functional outcome or length of stay in survivors (Ovbiagele and Nguyen-Huynh 2011;Kammersgaard et al 2001;Aslanyan et al 2004). …”

Section: Inflammation and Outcome Following Ischemic Strokementioning

confidence: 99%

The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research

Smith

Lawrence

Rodriguez‐Grande

et al. 2013

J Neuroimmune Pharmacol

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Stroke represents an unresolved challenge for both developed and developing countries and has a huge socio-economic impact. Although considerable effort has been made to limit stroke incidence and improve outcome, strategies aimed at protecting injured neurons in the brain have all failed. This failure is likely to be due to both the incompleteness of modelling the disease and its causes in experimental research, and also the lack of understanding of how systemic mechanisms lead to an acute cerebrovascular event or contribute to outcome.Inflammation has been implicated in all forms of brain injury and it is now clear that immune mechanisms profoundly influence (and are responsible for the development of) risk and causation of stroke, and the outcome following the onset of cerebral ischemia. Until very recently, systemic inflammatory mechanisms, with respect to common comorbidities in stroke, have largely been ignored in experimental studies. The main aim is therefore to understand interactions between the immune system and brain injury in order to develop novel therapeutic approaches. Recent data from clinical and experimental research clearly show that systemic inflammatory diseases -such as atherosclerosis, obesity, diabetes or infectionsimilar to stress and advanced age, are associated with dysregulated immune responses which can profoundly contribute to cerebrovascular inflammation and injury in the central nervous system. In this review, we summarize recent advances in the field of inflammation and stroke, focusing on the challenges of translation between pre-clinical and clinical studies, and potential anti-inflammatory/immunomodulatory therapeutic approaches.

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Section: Inflammation and Outcome Following Ischemic Strokementioning

confidence: 99%

The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research

Smith

Lawrence

Rodriguez‐Grande

et al. 2013

J Neuroimmune Pharmacol

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“…11,29,33 There are three types of strokes, which include Ischemic (88%) Hemorrhagic (12%) and Transient (rare type). 6,8,18 According to WHO, 15 million people worldwide suffer from stroke each year. 6 In India incidence of stroke is 145/100,000 per year during 2003-06.…”

Section: Introductionmentioning

confidence: 99%

Study of Symptoms, Risk Factors and Prescribing Patterns in Cerebral Stroke Patients

Konduru¹,

Ranjan²,

Nallajerla³

et al. 2017

IJOPP

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A prospective observational study was conducted at Bhimavaram hospitals Bhimavaram, to assess the symptoms, risk factors and prescribing patterns in cerebral stroke patients. A total of 80 patients of age group 20-90 (mean age 63.1) were considered in the study which includes both the genders. These patients were assessed regarding their demographics, symptoms, risk factors and prescribing patterns. The incidence of stroke was higher in males (70%) compared to females (30%). Out of these study population 85% experienced Ischemic stroke, 11% Transient ischemic attack (TIA) and 4% Hemorrhagic stroke. These patients presented weakness as common symptom, Hypertension as prominent risk factor and anti-platelet agents as commonly prescribed drugs. Early management of Hypertension and Diabetes may reduce the risk of stroke. Our study suggests that life style changes play a key role in prevention of stroke.

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“…The incidence of atrial fibrillation related ischemic stroke rapidly increases with age, doubling for each decade after age 55. In general population prevalence of AF is around 1%, but by 60 it is 2-4% and >80 years of age it is 9-13% per patient-year [3][4][5].…”

Section: Anticoagulantsmentioning

confidence: 99%

Hemorrhage After Lunch?

Télessy¹

2018

J Nutr Food Sci

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Medication induced hemorrhage during therapy with vitamin K antagonists (VKAs) is a relatively frequent adverse drug reaction. In order to minimize the risk for bleedings patients should take care of their concomitant medication and diet inclusive the dietary supplements. Here we address the question of risk factors of bleeding in patients taking warfarin and other VKAs. Special attention is paid to interactions between food ingredients and the anticoagulant therapy.

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Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy

Cited by 339 publications

References 86 publications

The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research

The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research

Study of Symptoms, Risk Factors and Prescribing Patterns in Cerebral Stroke Patients

Hemorrhage After Lunch?

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