Strobilanthes cusia (Nees) Kuntze, a multifunctional traditional Chinese medicinal plant, and its herbal medicines: A comprehensive review

Yu, Han Young; Li, Ting-na; Ran, Qian; Huang, Qinwan; Wang, Jin

doi:10.1016/j.jep.2020.113325

Cited by 37 publications

(29 citation statements)

References 65 publications

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“…Indigo is still widely used in traditional textiles, even though other natural plant dyes are rarely used. Strobilanthes cusia (Nees) Kuntze is the most widely used species in China for indigo preparation [ 13 , 14 ]. Strobilanthes spp.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Fingerprint Biosensor for Natural Indigo Dye Yielding Plants Analysis

Fan

Wang

et al. 2021

Biosensors

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Indigo is a plant dye that has been used as an important dye by various ancient civilizations throughout history. Today, due to environmental and health concerns, plant indigo is re-entering the market. Strobilanthes cusia (Nees) Kuntze is the most widely used species in China for indigo preparation. However, other species under Strobilanthes have a similar feature. In this work, 12 Strobilanthes spp. were analyzed using electrochemical fingerprinting technology. Depending on their electrochemically active molecules, they can be quickly identified by fingerprinting. In addition, the fingerprint obtained under different conditions can be used to produce scattered patter and heatmap. These patterns make plant identification more convenient. Since the electrochemically active components in plants reflect the differences at the gene level to some extent, the obtained electrochemical fingerprints are further used for the discussion of phylogenetics.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Fingerprint Biosensor for Natural Indigo Dye Yielding Plants Analysis

Fan

Wang

et al. 2021

Biosensors

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“…The medicinal uses of Qingdai include the treatment of various inflammatory diseases, oral ulcers, and skin diseases. Nanbanlangen has demonstrated efficacy in preventing and treating influenza A infection, mumps, and other infectious diseases (Tanaka et al, 2004 ; Yu et al, 2021 ). The phytochemical analyses showed that S. cusia can produce high quantities of biologically active compounds, such as, indole alkaloids (IAs), quinolone alkaloids, phenylethanoid glycosides, lignan glycosides, triterpenoids, steroids, amino acids, and flavonoids (Gu et al, 2014 ; Xiao et al, 2018 ; Yu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Nanbanlangen has demonstrated efficacy in preventing and treating influenza A infection, mumps, and other infectious diseases (Tanaka et al, 2004 ; Yu et al, 2021 ). The phytochemical analyses showed that S. cusia can produce high quantities of biologically active compounds, such as, indole alkaloids (IAs), quinolone alkaloids, phenylethanoid glycosides, lignan glycosides, triterpenoids, steroids, amino acids, and flavonoids (Gu et al, 2014 ; Xiao et al, 2018 ; Yu et al, 2021 ). Among these chemical components, indigo and indirubin are the major medicinal ingredients and are isomers of each other (C 16 H 10 N 2 O 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…Owing to its long history of herbal use, wide distribution, and efficacy, S. cusia is in high demand in developing countries (Pal and Shukla, 2003 ; Yu et al, 2021 ). The Herbs Genome Program is a whole-genome sequencing and post-genomics study of medicinal plants with economically important and characteristic secondary metabolic pathways.…”

Section: Introductionmentioning

confidence: 99%

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High-Quality Genome of the Medicinal Plant Strobilanthes cusia Provides Insights Into the Biosynthesis of Indole Alkaloids

Ning

et al. 2021

Front. Plant Sci.

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Strobilanthes cusia (Nees) Kuntze is an important plant used to process the traditional Chinese herbal medicines “Qingdai” and “Nanbanlangen”. The key active ingredients are indole alkaloids (IAs) that exert antibacterial, antiviral, and antitumor pharmacological activities and serve as natural dyes. We assembled the S. cusia genome at the chromosome level through combined PacBio circular consensus sequencing (CCS) and Hi-C sequencing data. Hi-C data revealed a draft genome size of 913.74 Mb, with 904.18 Mb contigs anchored into 16 pseudo-chromosomes. Contig N50 and scaffold N50 were 35.59 and 68.44 Mb, respectively. Of the 32,974 predicted protein-coding genes, 96.52% were functionally annotated in public databases. We predicted 675.66 Mb repetitive sequences, 47.08% of sequences were long terminal repeat (LTR) retrotransposons. Moreover, 983 Strobilanthes-specific genes (SSGs) were identified for the first time, accounting for ~2.98% of all protein-coding genes. Further, 245 putative centromeric and 29 putative telomeric fragments were identified. The transcriptome analysis identified 2,975 differentially expressed genes (DEGs) enriched in phenylpropanoid, flavonoid, and triterpenoid biosynthesis. This systematic characterization of key enzyme-coding genes associated with the IA pathway and basic helix-loop-helix (bHLH) transcription factor family formed a network from the shikimate pathway to the indole alkaloid synthesis pathway in S. cusia. The high-quality S. cusia genome presented herein is an essential resource for the traditional Chinese medicine genomics studies and understanding the genetic underpinning of IA biosynthesis.

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“…Our study demonstrated the inhibition effects of INAE on cytokines and chemokines, peroxide production, and suppression of neutrophilia in ltration (re ected by MPO level in Fig.7). Based on the bene cial effect of INAE, we supposed that INAE might reduce the risk of cytokine storm in severe virus infection.Indigo Naturalis mainly contains indigo, indirubin, tryptanthrin and other alkaloids, as well as indigo ketone, terpenoids, sitosterol and amino acids[78,79]. Indigo and indirubin are the main components of Indigo Naturalis and are the two important indicators for the quality of Indigo Naturalis in the Chinese…”

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confidence: 99%

Beneficial effect of Indigo Naturalis on acute lung injury induced by influenza A virus

Tian

et al. 2020

Preprint

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Background: Infections induced by influenza viruses, as well as coronavirus disease 19 (COVID-19) pandemic induced by severe acute respiratory coronavirus 2 (SARS-CoV-2) led to acute lung injury (ALI) and multi organ failure, during which traditional Chinese medicine (TCM) played an important role in treatment of the pandemic. The study aimed to investigate the effect of Indigo Naturalis on ALI induced by influenza A virus (IAV) in mice.Method: The anti-influenza and anti-inflammatory properties of aqueous extract of Indigo Naturalis (INAE) were evaluated in vitro. BALB/c mice inoculated intranasally with IAV (H1N1) were treated intragastrically with INAE (40, 80 and 160 mg·kg-1/d) 2 h later for 4 or 7 days. Animal lifespan and mortality were recorded. Expression of high mobility group box-1 protein (HMGB-1) and toll-like receptor 4 (TLR4) were evaluated through immunohistological staining. Inflammatory cytokines were also monitored by ELISA.Result: INAE inhibited virus replication on Madin-Darby canine kidney (MDCK) cells and decreased nitric oxide (NO) production from lipopolysaccharide (LPS)-stimulated peritoneal macrophages in vitro. The results showed that oral administration of 160 mg/kg of INAE significantly improved the lifespan (P < 0.01) and survival rate of IAV infected mice, improved lung injury and lowered viral replication in lung tissue (P < 0.01). Treatment with INAE (40, 80 and 160 mg/kg) significantly increased liver weight and liver index (P < 0.05), as well as weight and organ index of thymus and spleen at 160 mg/kg (P < 0.05). Serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels were reduced by INAE administration (P < 0.05). The expression of HMGB-1 and TLR4 in lung tissue were also suppressed. The increased production of myeloperoxidase (MPO) and methylene dioxyamphetamine (MDA) in lung tissue were inhibited by INAE treatment (P < 0.05). Treatment with INAE reduced the high levels of interferon α (IFN-α), interferon β (IFN-β), monocyte chemoattractant protein-1 (MCP-1), regulated upon activation normal T cell expressed and secreted factor (RANTES), interferon induced protein-10 (IP-10), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) (P < 0.05), with increased production of interferon γ (IFN-γ) and interleukin-10 (IL-10) (P < 0.05).Conclusion: The results showed that INAE alleviated IAV induced ALI in mice. The mechanisms of INAE were associated with its anti-influenza, anti-inflammatory and anti-oxidation properties. Indigo Naturalis might have clinical potential to treat ALI induced by IAV.

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Strobilanthes cusia (Nees) Kuntze, a multifunctional traditional Chinese medicinal plant, and its herbal medicines: A comprehensive review

Cited by 37 publications

References 65 publications

Electrochemical Fingerprint Biosensor for Natural Indigo Dye Yielding Plants Analysis

Electrochemical Fingerprint Biosensor for Natural Indigo Dye Yielding Plants Analysis

High-Quality Genome of the Medicinal Plant Strobilanthes cusia Provides Insights Into the Biosynthesis of Indole Alkaloids

Beneficial effect of Indigo Naturalis on acute lung injury induced by influenza A virus

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