Stretching of fetal membranes increases the concentration of interleukin-8 and collagenase activity

Maradny, Emad El; Kanayama, Naohiro; Halim, Abdul; Maehara, Kayoko; Terao, Toshihiko

doi:10.1016/s0002-9378(96)70311-3

Cited by 94 publications

(52 citation statements)

References 23 publications

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“…In vitro stretch of myometrial strips also increases prostaglandin H synthase 2 (PGHS-2) and prostaglandin E [57]. Stretching the muscle of the lower uterine segment has been shown to increase interleukin-8 (IL-8) and collagenase production, which in turn facilitates cervical ripening [58,59]. However, experimental animal models for uterine overdistension do not currently exist, and human studies have been entirely observational in nature.…”

Section: Pathways To Spontaneous Preterm Birthmentioning

confidence: 99%

Global report on preterm birth and stillbirth (2 of 7): discovery science

Gravett

Rubens

Nunes

2010

BMC Pregnancy Childbirth

172

136

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BackgroundNormal and abnormal processes of pregnancy and childbirth are poorly understood. This second article in a global report explains what is known about the etiologies of preterm births and stillbirths and identifies critical gaps in knowledge. Two important concepts emerge: the continuum of pregnancy, beginning at implantation and ending with uterine involution following birth; and the multifactorial etiologies of preterm birth and stillbirth. Improved tools and data will enable discovery scientists to identify causal pathways and cost-effective interventions.Pregnancy and parturition continuumThe biological process of pregnancy and childbirth begins with implantation and, after birth, ends with the return of the uterus to its previous state. The majority of pregnancy is characterized by rapid uterine and fetal growth without contractions. Yet most research has addressed only uterine stimulation (labor) that accounts for <0.5% of pregnancy.EtiologiesThe etiologies of preterm birth and stillbirth differ by gestational age, genetics, and environmental factors. Approximately 30% of all preterm births are indicated for either maternal or fetal complications, such as maternal illness or fetal growth restriction. Commonly recognized pathways leading to preterm birth occur most often during the gestational ages indicated: (1) inflammation caused by infection (22-32 weeks); (2) decidual hemorrhage caused by uteroplacental thrombosis (early or late preterm birth); (3) stress (32-36 weeks); and (4) uterine overdistention, often caused by multiple fetuses (32-36 weeks). Other contributors include cervical insufficiency, smoking, and systemic infections. Many stillbirths have similar causes and mechanisms. About two-thirds of late fetal deaths occur during the antepartum period; the other third occur during childbirth. Intrapartum asphyxia is a leading cause of stillbirths in low- and middle-income countries.RecommendationsUtilizing new systems biology tools, opportunities now exist for researchers to investigate various pathways important to normal and abnormal pregnancies. Improved access to quality data and biological specimens are critical to advancing discovery science. Phenotypes, standardized definitions, and uniform criteria for assessing preterm birth and stillbirth outcomes are other immediate research needs.ConclusionPreterm birth and stillbirth have multifactorial etiologies. More resources must be directed toward accelerating our understanding of these complex processes, and identifying upstream and cost-effective solutions that will improve these pregnancy outcomes.

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Section: Pathways To Spontaneous Preterm Birthmentioning

confidence: 99%

Global report on preterm birth and stillbirth (2 of 7): discovery science

Gravett

Rubens

Nunes

2010

BMC Pregnancy Childbirth

172

136

View full text Add to dashboard Cite

show abstract

“…The following mechanisms of disease have been implicated: 1) intrauterine infection/inflammation ; 2) uterine ischaemia [293][294][295][296][297][298][299][300][301][302][303][304][305][306][307]; 3) uterine overdistension [308][309][310][311][312][313][314][315][316][317][318][319][320][321][322][323][324][325][326][327]; 4) abnormal allogenic recognition [328][329][330][331][332][333][334][335]; 5) allergic-like reaction [336][337][338][339][340]; 6) cervical disease [341,…”

Section: Aetiologies Of the Preterm Parturition Syndromementioning

confidence: 99%

The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth

Gotsch

Romero²,

Erez

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

117

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“…A similar phenomenon has been demonstrated in cervical tissue and fetal membranes. 30 Recent work from our department has addressed the effects of stretching on different areas of vaginal skin in the same patient and shown that MMP expression is greater in non-rugose vaginal tissue that has been stretched by prolapse compared with non-stretched vaginal tissue (without rugae) taken from the same patient. Furthermore, a correlation was seen between the severity of prolapse and the elevation in MMP-2 expression in the areas of vaginal tissue that were stretched.…”

Section: Collagen Metabolism In Genitourinary Prolapsementioning

confidence: 99%

Urogynaecology: Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse

Phillips

Anthony

Benyon

et al. 2005

BJOG

112

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Objective To compare tissue markers of collagen metabolism in the uterosacral ligaments with those in vaginal tissue in women with uterine prolapse.Design Prospective observational experimental study.Setting A tertiary urogynaecology unit.Population Women referred for hysterectomy for prolapse or benign gynaecological disease.Methods Matrix metalloproteinase (MMP)‐2 and ‐9 expression, tissue inhibitors of metalloproteinase (TIMP)‐2 expression and hydroxyproline content were measured in the uterosacral ligaments and vaginal tissue from 14 women with prolapse compared with 14 controls.Main outcome measures Levels of MMP, TIMP and hydroxyproline in the uterosacral ligaments and vaginal tissue of women with prolapse and controls.Results Fourteen women with prolapse and 14 women without prolapse (controls) were included. A significant increase in pro MMP‐2 expression was seen in vaginal tissue from women with prolapse (P < 0.05) but not activated MMP‐2, MMP‐9 and TIMP‐2. For uterosacral ligaments, the differences were not statistically significant. No significant difference in hydroxyproline content was found between control and prolapse in either tissue. Significant correlations exist in expression of pro‐MMP‐2, activated MMP‐2, MMP‐9 and TIMP‐2 in vaginal tissue with that in uterosacral ligaments.Conclusions Correlations existed between markers of collagen metabolism in the vaginal and uterosacral tissues. This suggests vaginal tissue reflects the endopelvic fascia. The changes which are more pronounced in vaginal tissue may be as a result of prolapse rather than cause.

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Stretching of fetal membranes increases the concentration of interleukin-8 and collagenase activity

Cited by 94 publications

References 23 publications

Global report on preterm birth and stillbirth (2 of 7): discovery science

Global report on preterm birth and stillbirth (2 of 7): discovery science

The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth

Urogynaecology: Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse

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