Stretching-induced nanostructures on shape memory polyurethane films and their regulation to osteoblasts morphology

Xing, Juan; Ma, Yufei; Lin, Manping; Wang, Yuanliang; Pan, Haobo; Ruan, Changshun; Luo, Yanfeng

doi:10.1016/j.colsurfb.2016.06.044

Cited by 15 publications

(8 citation statements)

References 51 publications

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“…Linear biodegradable polyurethanes (LBPUs) have been attracting lots of attention in biomedical applications due to their fascinating properties such as biocompatibility, 1 biodegradability, 2 mechanical properties 3 and shape memory properties. 4,5 The most important one is that all performances of LBPUs can be tailored on the basis of the exible molecular designability of LBPUs. Specically, altering either the so segment (polyester doils or polyether doils) or hard segment (diisocyanate, chain extender) in LBPUs will vary their performances to satisfy the versatile requirements in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials

Liu

Luo

et al. 2017

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials

Liu

Luo

et al. 2017

RSC Adv.

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“…Nevertheless, the former exhibited higher shape fixation ratio (Table ) and faster shape recovery (Movies S1 and S2, Supporting Information), indicating better shape memory properties than PDLLA‐PEG400‐PDLLA4K‐PPZ‐PU. This can be explained by the stacks of UPy dimers, which can form physically crosslinked networks to induce stronger phase separation than the hydrogen‐bonding driven aggregation of urethane and urea groups in the control PDLLA‐PEG400‐PDLLA4K‐PPZ‐PU …”

Section: Resultsmentioning

confidence: 99%

Facile Preparation of Linear Polyurethane from UPy‐Capped Poly(dl‐Lactic Acid) Macrodiol

Ren

Chen

et al. 2018

Macro Materials & Eng

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Linear polyurethanes based on poly(dl‐lactic acid) (PDLLA) macrodiol are promising materials in tissue engineering, yet their synthesis requires rigorous control on various parameters. A facile way to prepare linear polyurethanes by capping the PDLLA macrodiol (M n = 4536) with 2‐ureido‐4[1H]‐pyrimidone (UPy) is reported. The obtained low‐molecular‐weight UPy‐capped polyurethane can form flexible, stretchable, and hydrophobic supramolecular films due to the strong and unidirectional quadruple hydrogen bonding of UPy dimers. Tensile tests, shape recovery, and self‐healing observations indicate that, compared with conventional PDLLA macrodiol‐based linear polyurethane (M n = 48840 and PDI = 1.8), the UPy‐capped polyurethane films have comparable mechanical properties (tensile modulus: 900 ± 38 MPa; ultimate strength: 9.6 ± 0.8 MPa) yet significantly better shape memory and self‐healing properties. These results suggest that the UPy‐capped polyurethane might become an alternative for conventional linear polyurethane as a new biomedical material.

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“…When an acidic degradable polymeric biomaterial is implanted for bone regeneration in the body, the host cell biological responses to the bone graft may be mainly dependent on the cell/material interaction, which can be regulated by material characteristics such as surface topography 34 , surface hydrophilicity 35, 36 , and chemical composition 37 . Luo et al .…”

Section: Discussionmentioning

confidence: 99%

The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior

Ruan

et al. 2017

Sci Rep

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A weak alkaline environment is established to facilitate the growth of osteoblasts. Unfortunately, this is inconsistent with the application of biodegradable polymer in bone regeneration, as the degradation products are usually acidic. In this study, the variation of the interfacial pH of poly (D, L-lactide) and piperazine-based polyurethane ureas (P-PUUs), as the representations of acidic degradable materials, and the behavior of osteoblasts on these substrates with tunable interfacial pH were investigated in vitro. These results revealed that the release of degraded products caused a rapid decrease in the interfacial pH, and this could be relieved by the introduction of alkaline segments. On the contrary, when culturing with osteoblasts, the variation of the interfacial pH revealed an upward tendency, indicating that cell could construct the microenvironment by secreting cellular metabolites to satisfy its own survival. In addition, the behavior of osteoblasts on substrates exhibited that P-PUUs with the most PP units were better for cell growth and osteogenic differentiation of cells. This is due to the hydrophilic surface and the moderate N% in P-PUUs, key factors in the promotion of the early stages of cellular responses, and the interfacial pH contributing to the enhanced effect on osteogenic differentiation.

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Stretching-induced nanostructures on shape memory polyurethane films and their regulation to osteoblasts morphology

Cited by 15 publications

References 51 publications

Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials

Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials

Facile Preparation of Linear Polyurethane from UPy‐Capped Poly(dl‐Lactic Acid) Macrodiol

The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior

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