Stretching Exercises Improve Vascular Endothelial Dysfunction Through Attenuation of Oxidative Stress in Chronic Heart Failure Patients With an Implantable Cardioverter Defibrillator

Kato, Michitaka; Masuda, Takashi; Ogano, Michio; Hotta, Kyoko; Takagi, Hisato; Tanaka, Shinya; Kamada, Yumi; Akiyama, Ayako; Shimizu, Ryo; Tabata, Minoru; Tanabe, Jun; Umemoto, Takuya

doi:10.1097/hcr.0000000000000229

Cited by 23 publications

(35 citation statements)

References 48 publications

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“…Thus, its response seems to be only marginally influenced by the sympathetic activity (Venturelli et al 2017a,b). Previous studies reported enhanced vascular function of the stretched limb after PS training only indirectly as measured with the reactive hyperaemia peripheral tonometry index (Hotta et al 2013;Kato et al 2017;Shinno et al 2017), a technique mainly related to better NO bioavailability due to shear stress-induced vasodilatation (Matsuzawa et al 2015). FMD results in the present study are in line with the previously published data: indeed, an improvement in vascular function in the arteries directly involved with PS training was noted for both training groups under investigation.…”

Section: Ps Training-induced Changes In Vascular Functionsupporting

confidence: 92%

“…Blood flow (Q ) distribution throughout body vasculature is strongly influenced by the balance of the sympathetic activity (Sandoo et al 2010;Thijssen et al 2014;Venturelli et al 2019) and localized vasodilator mechanisms (Widlansky et al 2003;Wilson et al 2016). Recent studies have reported that acute passive static stretching (PS), a well-established practice in rehabilitation and sport to increase joint range of motion (ROM) (Esposito et al 2011;Kay & Blazevich, 2012;Behm et al 2015), may have a positive effect on vascular function, arterial stiffness and arterial structure (Cortez-Cooper et al 2008;Kato et al 2017;Shinno et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the relaxation phase in between two subsequent stretches is always characterized by hyperaemia due to a reduction in peripheral vascular resistance after stretch-induced deformation of the vessel (Venturelli et al 2019). While the effects of acute PS onQ , and vascular function and structure in the feeding arteries of the stretched muscle have been already extensively investigated, some data are also available on vascular function and arterial stiffness ameliorations induced by long-term PS training (Cortez-Cooper et al 2008;Kato et al 2017;Shinno et al 2017). However, the indirect approach used in the previous studies to assess vascular function changes after PS training did not permit evaluation of possible PS training-induced mechanical remodulations of the arterial wall in the vessels directly involved in PS training.…”

Section: Introductionmentioning

confidence: 99%

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Evidence for improved systemic and local vascular function after long‐term passive static stretching training of the musculoskeletal system

Bisconti

Cè

Longo

et al. 2020

The Journal of Physiology

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Key points Vascular function and arterial stiffness are important markers of cardiovascular health and cardiovascular co‐morbidity. Transitional phases of hypoemia and hypermia, with consequent fluctuations in shear rate, occuring during repetitive passive stretching adminstration (passive stretching training) may constitute an effective stimulus to induce an amelioration in vascular function, arterial stiffness and vascular remodelling by improving central and local blood flow control mechanisms. Vascular function, arterial stiffness and vascular remodelling were evaluated before and after 12 weeks of passive stretching training and after 6 weeks from training cessation, in the femoral, popliteal (treated with stretching), and brachial arteries (untreated) of both sides. After passive stretching training, vascular function and arterial remodelling improved, and arterial stiffness decreased in all the arteries, suggesting modifications of both central and local blood flow control mechanisms. Passive stretching‐induced improvements related to central mechanisms seemed to have a short duration, as they returned to pre‐training baseline within 6 weeks from training cessation, whereas those more related to a local mechanism persisted in the follow‐up. Abstract Acute passive stretching (PS) effects on blood flow (trueQ̇), shear rate (trueẎ), and vascular function in the feeding arteries of the stretched muscle have been extensively investigated; however, few data are available on vascular adjustments induced by long‐term PS training. We investigated the effects of PS training on vascular function and stiffness of the involved (femoral and popliteal) and uninvolved (brachial) arteries. Our hypothesis was that PS‐induced changes in trueQ̇ and trueẎ would improve central and local mechanisms of trueQ̇ control. Thirty‐nine participants were randomly assigned to bilateral PS (n = 14), monolateral PS (n = 13) or no PS training (n = 12). Vascular function was measured before and after 12 weeks of knee extensor and plantar flexor muscles’ PS training by single passive limb movement and flow‐mediated dilatation (FMD). Central (carotid‐femoral artery PWV, PWVCF) and peripheral (carotid‐radial artery PWV, PWVCR) arterial stiffness was measured by pulse‐wave velocity (PWV), together with systolic (SBP) and diastolic (DBP) blood pressure. After PS training, increases of 30%, 25% and 8% (P < 0.05) in femoral ΔtrueQ̇, popliteal and brachial artery FMD%, respectively, occurred in both PS training groups. A decrease in PWVCF, PWVCR, SBP and DBP (−25%, −17%, −4% and −8%, respectively; P < 0.05) was noted. No changes occurred in controls. Vascular function improved and arterial stiffness reduced in the arteries involved and uninvolved with PS training, suggesting modifications in both central and local trueQ̇ control mechanisms. PS‐induced improvements had a short duration in some of vascular function parameters, as they returned to baseline within 6 weeks of PS training cessation.

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Section: Ps Training-induced Changes In Vascular Functionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evidence for improved systemic and local vascular function after long‐term passive static stretching training of the musculoskeletal system

Bisconti

Cè

Longo

et al. 2020

The Journal of Physiology

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show abstract

“…Physical poses take limbs and spine to great range of motion, demanding mostly agonists' isometric contractions and antagonists' muscle group stretching (Jorge et al, 2016 ). In recent years, stretching has been regarded as an exercise able to promote changes on vascular function (Kato et al, 2017 ). Positive effects of single bouts of stretching have been reported, although mechanisms involved in such responses are not fully elucidated, and no studies have been carried out on chronic effects of this kind of exercise (Kruse et al, 2016 ; Kruse and Scheuermann, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Additional Improvement of Respiratory Technique on Vascular Function in Hypertensive Postmenopausal Women Following Yoga or Stretching Video Classes: The YOGINI Study

Fetter¹,

Marques²,

Souza³

et al. 2020

Front. Physiol.

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Background: Hypertension remains highly prevalent in postmenopausal women, along with vascular dysfunction and increased oxidative stress. In such context, regular exercises, yoga practice, and slow breathing have been recommended to treat hypertension. However, the effects of the multiple components of yoga, including the respiratory techniques involved in the practice, on hypertension and on vascular and endothelial function have never been evaluated. Objective: This study aimed to investigate the additional effects of respiratory technique on vascular function and oxidative stress profile in hypertensive postmenopausal women (HPMWs) following yoga or stretching video classes. Study Design: Hypertensive postmenopausal women were recruited and randomized for 12 weeks, twice a week, of supervised yoga or stretching video classes of 75 min for 12 weeks associated or not with respiratory technique. Baseline and post-intervention measurements included pulse wave velocity (PWV), flow-mediated dilation (FMD), and oxidative stress parameters. Hypertensive postmenopausal women (59 ± 0.7 years) who ended the protocol were distributed into three groups: (1) control group (yoga or stretching, C, n = 14); (2) yoga + respiratory technique (Y+, n = 10); (3) stretching + respiratory technique (S+, n = 9). Results: Diastolic blood pressure and FMD [baseline: C: 6.94 ± 1.97%, Y+: 7.05 ± 1.65%, and S+: 3.54 ± 2.01% vs. post: C: 16.59 ± 3.46% ( p = 0.006), Y+: 13.72 ± 2.81% ( p = 0.005), and S+: 11.79 ± 0.99% ( p = 0.0001)] have significantly increased in all groups when baseline and post-practice values were compared. However, resting heart rate and PWV [baseline: Y+: 10.44 ± 3.69 and S+: 9.50 ± 0.53 m/s vs. post: Y+: 9.45 ± 0.39 ( p = 0.003) and S+: 8.02 ± 0.47 m/s ( p = 0.003)] decreased significantly only in the Y+ and S+ groups (baseline vs. post). Systemic antioxidant enzyme activities (superoxide dismutase and catalase) increased in all groups, and hydrogen peroxide and lipoperoxidation reduced in Y+ and S+ (baseline vs. post). Conclusions: Twelve weeks of yoga or stretching video classes promoted positive changes in several outcomes generally regarded as cardiovascular risk factors in HPMWs, and these changes were even more pronounced by the association with respiratory technique.

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“…In regard to stretching exercises, RH-PAT index was significantly higher immediately after the exercise than before, which was accompanied by increasing of high-frequency components (HF, 0.15-0.40 Hz) of heart rate variability as an indicator of parasympathetic nervous activities, and transcutaneous Oxygen Pressure (tcPO 2 ) on the right Foot and Chest ratio (Foot-tcPO 2 /Chest-tcPO 2 ) [50]. Cardiac rehabilitation with 4-week stretching exercises induced a significant increase in the RH-PAT index and significant decreases in serum levels of von Willebland Factor (vWF), Malondialdehyde-modified Low-Density Lipoprotein cholesterol (MDA-LDL), reactive oxygen species, and fibrinogen concentrations [51]. Cardiac rehabilitation exercise training program of moderate intensity (3 session/ week on a bicycle at 60-70% of Heart Rate Reserve (HRR) for 3 months, followed by one session/week until 1-year follow-up) improved cardiopulmonary function measured by cardiopulmonary exercise stress test and endothelial function measured by RH-PAT in women in breast cancer [52].…”

Section: Vascular Endothelial Function and Coronary Artery Diseasementioning

confidence: 99%

Endothelial Function for Cardiovascular Disease Prevention and Management

Yamaoka‐Tojo¹

2017

Int J Clin Cardiol

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Stretching Exercises Improve Vascular Endothelial Dysfunction Through Attenuation of Oxidative Stress in Chronic Heart Failure Patients With an Implantable Cardioverter Defibrillator

Abstract: Four weeks of stretching exercises improved vascular endothelial dysfunction through attenuation of oxidative stress in sedentary patients with CHF with an ICD or CRT-D.

Cited by 23 publications

References 48 publications

Evidence for improved systemic and local vascular function after long‐term passive static stretching training of the musculoskeletal system

Evidence for improved systemic and local vascular function after long‐term passive static stretching training of the musculoskeletal system

Additional Improvement of Respiratory Technique on Vascular Function in Hypertensive Postmenopausal Women Following Yoga or Stretching Video Classes: The YOGINI Study

Endothelial Function for Cardiovascular Disease Prevention and Management

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