Stressor controllability modulates stress‐induced serotonin but not dopamine efflux in the nucleus accumbens shell

Bland, Sondra T.; Twining, Carin; Watkins, Linda R.; Maier, Steven F.

doi:10.1002/syn.10229

Cited by 43 publications

(29 citation statements)

References 19 publications

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“…The nucleus accumbens (NAc) is an important part of the mesolimbic dopamine (DA) system. In the NAc, especially in the shell, changes in DA and its metabolites occur in response to variety of stressor including an immune challenge (Kalivas and Duffy, 1995;Wu et al, 1999;Bland et al, 2003;Delarue et al, 2003). Systemic administration of proinflammatory cytokine interleukin-1b (IL-1) has been reported to reduce libido and social interaction, stimulate glucocorticoid secretion, induce anhedonia and stress/anxiety-like behavior (Dantzer et al, 1998;van der Meer et al, 1996;Brebner et al, 2000;Anisman et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Omega-3 Fatty Acid Ethyl-Eicosapentaenoate Attenuates IL-1β-Induced Changes in Dopamine and Metabolites in the Shell of the Nucleus Accumbens: Involved with PLA2 Activity and Corticosterone Secretion

Song

Kang

et al. 2006

Neuropsychopharmacol

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Previously, we have reported that interleukin-1 b (IL-1) induces changes in dopaminergic (DA) and serotonergic systems in the core of nucleus accumbens (NAc). We have also demonstrated that n-3 fatty acid ethyl-eicosapentaenoate (EPA) can significantly reduce stress and anxiety-like behaviors, corticosterone concentration and peripheral inflammatory response induced by IL-1 administration. Compared to the core, the shell is involved more in emotion, stress and psychiatric diseases. However, the relationship between inflammation and the functions of DA system in the shell has not been studied. Since phospholipase (PL) A2 is a key enzyme in arachidonic acid (AA)-eicosanoids-prostaglandin (PG)E2 pathway, and the change in NAc dopaminergic system has been associated with glucocorticoid stimulation, therefore, the hypotheses of this study are (1) that IL-1 induced changes in DA neurotransmission in the shell may be through PLA2-PGE2-corticosterone pathway; (2) EPA may attenuate IL-1 effects via inhibiting PLA2 activities, which blocks PGE2 stimulation of corticosterone. Using an in vivo microdialysis method, the present study showed that IL-1 administration significantly increased extracellular levels of DA, and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the shell of the NAc. IL-1 also increased blood concentration of corticosterone and PGE2, and increased the activities of cytosolic and sectory of PLA2. IL-1-induced changes were significantly attenuated by EPA treatment. Furthermore, glucorcoticoid receptor antagonist mifepristone (RU486) pretreatment significantly blocked IL-1-induced changes in DA and metabolites. Qquinacrine, a PLA2 antagonist significantly blocked IL-1 induced increase in PGE2 and corticosterone concentrations. These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion. Neuropsychopharmacology (2007) 32, 736-744.

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Section: Introductionmentioning

confidence: 99%

Omega-3 Fatty Acid Ethyl-Eicosapentaenoate Attenuates IL-1β-Induced Changes in Dopamine and Metabolites in the Shell of the Nucleus Accumbens: Involved with PLA2 Activity and Corticosterone Secretion

Song

Kang

et al. 2006

Neuropsychopharmacol

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“…Levels of DA, the associated metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), serotonin (5-HT), and the intracellular DA turnover (DOPAC/DA) were determined in frontal cortex, nucleus accumbens, and frontal cortex using methods established in our laboratory (Thiruchelvam et al 2000) and measured at a sensitivity of 2 nA for striatum and frontal cortex and 1 nA for nucleus accumbens. These neurotransmitters have demonstrated sensitivity to Pb (CorySlechta et al 1992(CorySlechta et al , 1996Kala and Jadhav 1995;Pokora et al 1996) and to stress (Armando et al 2003;Bland et al 2003;ChouGreen et al 2003;Finlay and Zigmond 1997;Hanley and Van de Kar 2003;Mangiavacchi et al 2001;Scheggi et al 2002). DA and 5-HT play key roles in the brain regions examined, which include components of both the nigrostriatal and mesolimbic DA systems, thus also allowing some assessment of specificity of effects.…”

Section: Methodsmentioning

confidence: 99%

Maternal stress modulates the effects of developmental lead exposure.

Cory‐Slechta

Virgolini

Thiruchelvam

et al. 2004

Environ Health Perspect

161

145

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Lead exposure is higher among children with low socioeconomic status (SES) compared with other children in the United States. Low SES itself is a known risk factor for various diseases and dysfunctions, effects that have been ascribed to chronic stress and associated elevation of glucocorticoids. Chronically elevated glucocorticoids and Pb provoke similar behavioral changes, and both can act on mesocorticolimbic systems of the brain. In this study we examined the hypothesis that these co-occurring risk factors, Pb and environmental stress, would interact and modulate each others' effects. Using a rodent model, we focused on the specific contributions of maternal stress (restraint) and maternal Pb exposure (150 ppm in drinking water) on corticosterone levels of offspring, as well as on neurotransmitter changes and a behavioral baseline (fixed-interval schedulecontrolled performance) with known sensitivities to Pb. We observed interactions of Pb and stress that differed in relation to outcome measure and sex. In addition, potentiated effects (effects of Pb plus stress but showing no changes produced by either alone) were observed more frequently in females. Importantly, Pb alone (in males) and Pb plus stress (in females) permanently elevated corticosterone levels in offspring; even short-term Pb exposure to dams could cause this effect. Such increases could suggest a potential new mechanism by which Pb exposure could directly or indirectly enhance susceptibility to diseases and dysfunctions and induce cognitive deficits. Moreover, the interactive effects of Pb and stress, and particularly the potentiated effects of Pb plus stress, raise questions about whether current risk assessment strategies sufficiently consider the potential for modulation of toxicity that can accrue from intercurrent risk factors.

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“…Exaggerated release of 5-HT within the DRN during uncontrollable stress could sensitize DRN 5-HT neurons by down-regulating somatodendritic 5-HT 1A inhibitory autoreceptors in the DRN (Riad et al 2001;Short et al 2000), thus removing an important inhibitory influence over the firing of DRN 5-HT neurons. Indeed, hyperactivation of the DRN leads to sensitization of the DRN so that during behavioral testing 24 h after exposure to uncontrollable tail shock stress, there is exaggerated 5-HT release in DRN projection sites including the amygdala (Amat et al 1998a,b;Bland et al 2003). Importantly, manipulations that activate DRN 5-HT neurons (Maier et al 1995a) or increase extracellular 5-HT in the DRN (Greenwood and Fleshner 2008) produce exaggerated shockelicited freezing and interfere with shuttle box escape performance in the absence of stress, and the behavioral consequences of uncontrollable stressors can be prevented by DRN lesions (Maier et al 1993) or manipulations that reduce activation of DRN 5-HT neurons (Maier et al 1995b).…”

Section: Introductionmentioning

confidence: 99%

Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise

et al. 2008

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Rationale-Although selective 5-HT reuptake inhibitors (SSRIs) can reduce anxiety after chronic treatment, acute SSRI administration is associated with an increase in anxiety consistent with an acute increase in 5-HT neurotransmission. Exercise is anxiolytic in humans, and wheel running prevents anxiety-like behavioral consequences of uncontrollable stress in rats, but the effects of exercise on acute fluoxetine-induced anxiety-like behaviors are unknown.Objectives-The current studies tested the hypothesis that acute administration of the SSRI fluoxetine would produce behaviors in rats resembling those produced by uncontrollable stress and that these behaviors would be blocked by prior wheel running.Results-Adult, male Fisher 344 rats administered moderate (10 mg/kg) or high (20 mg/kg) doses of fluoxetine demonstrated exaggerated shock-elicited freezing and an interference with shuttle box escape compared to rats given either saline or low-dose fluoxetine (2.5 mg/kg). Fluoxetine-induced behaviors were similar to, but smaller in magnitude than, those produced by uncontrollable stress and were blocked by pretreatment with the 5-HT 2C receptor antagonist SB 242084 (1 mg/kg). Rats allowed access to running wheels for 6 weeks were protected against the anxiety-like behaviors produced by a single injection of fluoxetine (10 mg/kg).Conclusions-Behavioral effects of acute fluoxetine administration resemble those produced by uncontrollable stress. Results are consistent with the idea that exercise can produce resistance against the anxiogenic effects of acute increases in 5-HT and suggest that acute behavioral effects of antidepressants can depend on history of physical activity.

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Stressor controllability modulates stress‐induced serotonin but not dopamine efflux in the nucleus accumbens shell

Cited by 43 publications

References 19 publications

Omega-3 Fatty Acid Ethyl-Eicosapentaenoate Attenuates IL-1β-Induced Changes in Dopamine and Metabolites in the Shell of the Nucleus Accumbens: Involved with PLA2 Activity and Corticosterone Secretion

Omega-3 Fatty Acid Ethyl-Eicosapentaenoate Attenuates IL-1β-Induced Changes in Dopamine and Metabolites in the Shell of the Nucleus Accumbens: Involved with PLA2 Activity and Corticosterone Secretion

Maternal stress modulates the effects of developmental lead exposure.

Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise

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