Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise

Greenwood, Benjamin N.; Strong, Paul V.; Brooks, Leah; Fleshner, Monika

doi:10.1007/s00213-008-1167-y

Cited by 44 publications

(43 citation statements)

References 77 publications

(116 reference statements)

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“…Interestingly, a dose of 2 mg/kg of SB-269970 had no detectable effect in the present study by itself, suggesting a lack of modification of 5-HT release as previously shown (Bonaventure et al, 2007), it counteracted the anxiogenic-like effect of acute administration of fluoxetine in the illuminated open field (Figure 1). Previous reports have shown that the SSRIs fluoxetine and citalopram display anxiogenic behaviors via the activation of 5-HT 2C receptors as their effects were prevented by a 5-HT 2C antagonist (Burghardt et al, 2007;Dekeyne et al, 2000;Greenwood et al, 2008). Hence, it can be suggested that an enhanced activation of 5-HT 2C , and also of 5-HT 7 , receptors might be a mechanism for the anxiogenic effects of SSRIs observed initially during treatment, based on the present results.…”

Section: Discussionsupporting

confidence: 77%

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie-Filali

Faure

Lambás‐Señas

et al. 2011

Neuropsychopharmacol

128

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Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT 7 ) receptors produced a faster antidepressant-like response than the commonly prescribed antidepressant fluoxetine. In the rat, the selective 5-HT 7 receptor antagonist SB-269970 counteracted the anxiogenic-like effect of fluoxetine in the open field and exerted an antidepressant-like effect in the forced swim test. In vivo, 5-HT 7 receptors negatively regulate the firing activity of dorsal raphe 5-HT neurons and become desensitized after long-term administration of fluoxetine. In contrast with fluoxetine, a 1-week treatment with SB-269970 did not alter 5-HT firing activity but desensitized cell body 5-HT autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. Finally, unlike fluoxetine, early-life administration of SB-269970, did not induce anxious/depressive-like behaviors in adulthood. Together, these findings indicate that the 5-HT 7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action.

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Section: Discussionsupporting

confidence: 77%

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie-Filali

Faure

Lambás‐Señas

et al. 2011

Neuropsychopharmacol

128

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“…Prolonged access to running wheels has been shown to have anxiolytic effects in laboratory rodents (Duman et al 2008;Greenwood et al 2008;Sciolino and Holmes 2012), whereas the effects of acute exercise on anxiety levels are less clear (Youngstedt et al 1993). Thus, in Greenwood's (2009) study, extinction of a context fear memory may not have been affected by running access as rats exposed to chronic exercise were less Cold Spring Harbor Laboratory Press on March 21, 2019 -Published by learnmem.cshlp.org Downloaded from anxious or had lower levels of arousal following extinction training and therefore did not show enhanced extinction.…”

Section: Discussionmentioning

confidence: 99%

A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidation

2014

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Three experiments used rats to examine the effect of a single bout of voluntary activity (wheel running) on the acquisition, extinction, and reconsolidation of context conditioned fear. In Experiment 1, rats provided with access to a wheel for 3 h immediately before or after a shocked exposure to a context froze more when tested in that context than rats provided with access to the wheels 6 h after the shocked exposure or rats not provided with access to the wheels. In Experiment 2, rats provided with access to the wheels immediately before or after a nonshocked exposure to the conditioned context froze less when tested in that context than rats provided with access to the wheels 6 h after the nonshocked exposure or rats not provided with access to the wheels. In Experiment 3, rats provided with access to wheels immediately after an extended nonshocked exposure to the conditioned context again froze less, whereas rats provided with access to the wheels after a brief nonshocked exposure froze more on the subsequent test than sedentary controls. These results show that a single bout of running can enhance acquisition, extinction, and reconsolidation of context conditioned fear.Pavlovian conditioned fear is thought to contribute to anxiety disorders such as post-traumatic stress, and extinction of this fear is a goal of exposure-based treatments of post-traumatic stress disorder (Bouton et al. 2001). Hence, there has been interest in identifying variables that regulate the acquisition and extinction of fear responses in animal models in order to better understand posttraumatic stress and develop more effective treatments for this disorder. One of the variables that influence the acquisition of conditioned fear in rodents is a history of exercise. Rodents provided with access to running wheels for several weeks and then shocked in a distinctive context exhibit more fear (typically freezing responses) than sedentary controls (Baruch et al.

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“…Though chronic SSRI treatment is anxiolytic, acute SSRI application might be anxiogenic (30). It was also suggested that W-promoting effect of SSRIs might be secondary (81), as SSRI administration was found to cause behavioral and motor activation (9).…”

Section: Discussionmentioning

confidence: 99%

Sleep loss and recovery after administration of drugs related to different arousal systems in rats

Hajnik¹,

Tóth²,

Szalontai³

et al. 2016

Physiology International

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Sleep is homeostatically regulated suggesting a restorative function. Sleep deprivation is compensated by an increase in length and intensity of sleep. In this study, suppression of sleep was induced pharmacologically by drugs related to different arousal systems. All drugs caused non-rapid eye movement (NREM) sleep loss followed by different compensatory processes. Apomorphine caused a strong suppression of sleep followed by an intense recovery. In the case of fluoxetine and eserine, recovery of NREM sleep was completed by the end of the light phase due to the biphasic pattern demonstrated for these drugs first in the present experiments. Yohimbine caused a long-lasting suppression of NREM sleep, indicating that either the noradrenergic system has the utmost strength among the examined systems, or that restorative functions occurring normally during NREM sleep were not blocked. Arousal systems are involved in the regulation of various wakefulness-related functions, such as locomotion and food intake. Therefore, it can be hypothesized that activation of the different systems results in qualitatively different waking states which might affect subsequent sleep differently. These differences might give some insight into the homeostatic function of sleep in which the dopaminergic and noradrenergic systems may play a more important role than previously suggested.

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Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise

Cited by 44 publications

References 77 publications

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidation

Sleep loss and recovery after administration of drugs related to different arousal systems in rats

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