Stress und Covid-19: Ein Narrativer Review über
                    neuroendokrin-immune Mechanismen, die eine Abwehr von SARS-CoV-2 verbessern
                    könnten

Peters, Eva M.J.; Schedlowski, Manfred; Watzl, Carsten; Gimsa, Ulrike

doi:10.1055/a-1322-3205

Cited by 8 publications

(5 citation statements)

References 109 publications

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“…Protracted systemic inflammation is an important pathogenetic factor in depressive-anxious disorders during COVID-19 convalescence (7,10,24,30–32). Stress being the key co-variate of poor mental health in the study collectives was proposed to modulate anti-SARS-CoV-2 immunity culminating in more severe COVID-19 (33) and to perpetuate the systemic low-grade inflammation(28,33). Other possible mechanisms include direct viral infection of the central nervous system, neuroinflammation, microvascular thrombosis and neurodegeneration(34).…”

Section: Discussionmentioning

confidence: 99%

Who is at risk of poor mental health following COVID-19 outpatient management?

Hüfner

Tymoszuk

Ausserhofer³

et al. 2021

Preprint

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Background: COVID-19 convalescents are at risk of developing a de novo mental health disorder or of worsening of a pre-existing one. The objectives of our study was to phenotype individuals at highest risk of mental health disorders among COVID-19 outpatients. Methods: We conducted a binational online survey study with adult non-hospitalized COVID-19 convalescents (Austria/AT: n=1157, Italy/IT: n= 893). Primary endpoints were positive screening for depression and anxiety (PHQ-4, Patient Health Questionnaire) and self-perceived overall mental health and quality of life rated with 4 point Likert scales. Psychosocial stress was surveyed with a modified PHQ stress module. Associations of the mental health with socio-demographic variables, COVID-19 course and recovery data were assessed by multi-parameter random forest and serial univariable modeling. Mental disorder risk subsets were defined by self-organizing map and hierarchical clustering algorithms. The survey analyses are publicly available (https://im2-ibk.shinyapps.io/mental_health_dashboard/). Results: In the study cohorts, 4.6 (IT)/6% (AT) of participants reported depression and/or anxiety before to infection. At a median of 79 days (AT)/96 days (IT) post COVID-19 onset, 12.4 (AT)/19.3% (IT) of subjects were screened positive for anxiety and 17.3 (AT)/23.2% (IT) for depression. Over one-fifth of the respondents rated their overall mental health (AT: 21.8%, IT: 24.1%) or quality of life (AT: 20.3%, IT: 25.9%) as fair or poor. In both study collectives, psychosocial stress, high numbers of acute and persistent COVID-19 complaints and the presence of acute neurocognitive symptoms (impaired concentration, confusion, forgetfulness) were the strongest correlates of deteriorating mental health and poor quality of life. In clustering analysis, these variables defined a high risk subset with particularly high propensity of post-COVID-19 mental health impairment and decreased quality of life. Pre-existing depression or anxiety was associated with an increased symptom burden during acute COVID-19 and recovery. Conclusion: Our study revealed a bidirectional relationship between COVID-19 symptoms and mental health. We put forward specific acute symptoms of the disease as red flags of mental health deterioration which should prompt general practitioners to identify COVID-19 patients who may benefit from early psychological and psychiatric intervention. Trial registration: ClinicalTrials.gov: NCT04661462.

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Section: Discussionmentioning

confidence: 99%

Who is at risk of poor mental health following COVID-19 outpatient management?

Hüfner

Tymoszuk

Ausserhofer³

et al. 2021

Preprint

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“…Es ist außerdem hinreichend belegt, dass psychische und psychosomatische Vorerkrankungen Vulnerabilitätsfaktoren für das Auftreten von psychischen Long-/Post-COVID-Symptomen darstellen. Zudem legen psychoneuroimmunologische Konzepte nahe, dass insbesondere Stress zur Verschlechterung und Chronifizierung von inflammatorischen Erkrankungen beitragen kann 279 . Auch wurden Zusammenhänge zwischen initial schwacher Immunabwehr und langfristig erhöhten Inflammationsparametern mit Fatigue berichtet 173 .…”

Section: Psychische Aspekteunclassified

“…Rehabilitation angezeigt. Zentral ist die multimodale Behandlung der Patienten 279 324 . Dies schließt auch die Einbindung von Bewegungsangebotenangeboten 325 , Selbsthilfe-Gruppen (z.…”

Section: Psychische Aspekteunclassified

S1-Leitlinie Long-/Post-COVID

et al. 2022

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ZusammenfassungDie Deutsche Gesellschaft für Pneumologie hat 2021 die AWMF S1-Leitlinie Long-/Post-COVID initiiert. In einem breiten interdisziplinären Ansatz wurde diese S1-Leitlinie basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt die aktuellen Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen und konsentierten Einführung wurde ein fachspezifischer Zugang gewählt, der den aktuellen Wissensstand zusammenfasst.Die Leitlinie hat einen explizit praktischen Anspruch und wird basierend auf dem aktuellen Wissenszugewinn vom Autorenteam weiterentwickelt und adaptiert.

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“…Neuroendocrineimmune mechanisms might boost the risk of a SARS-CoV-2 infection and have a negative impact on the course of the following coronavirus disease . However, epidemiological data on the hypothesized interplay between emotional distress and an infection with SARS-CoV-2 are largely missing (Peters et al, 2021). Experimental studies have revealed that pre-existing emotional burden, such as stress or the feeling of loneliness, entails a risk of viral infection and may negatively impact the course of infectious diseases (Cohen et al, 1991;Cole et al, 2011;Cohen et al, 2015;LeRoy et al, 2017;Cohen, 2021).…”

Section: Introductionmentioning

confidence: 99%

Psychological Impact of COVID-19 on individuals: Through Active Choices and Passive Adaption

Fang,

Lau,

Yan

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Stress und Covid-19: Ein Narrativer Review über neuroendokrin-immune Mechanismen, die eine Abwehr von SARS-CoV-2 verbessern könnten

Cited by 8 publications

References 109 publications

Who is at risk of poor mental health following COVID-19 outpatient management?

Who is at risk of poor mental health following COVID-19 outpatient management?

S1-Leitlinie Long-/Post-COVID

Psychological Impact of COVID-19 on individuals: Through Active Choices and Passive Adaption

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