Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, Ian; Bambico, Francis Rodriguez; Mechawar, Naguib; Nóbrega, José N.

doi:10.1016/j.neubiorev.2013.11.009

Cited by 542 publications

(373 citation statements)

References 326 publications

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“…The observation that current antidepressant drugs promote adult hippocampal neurogenesis provides a much stronger evidence on this link (Mahar et al, 2014;Zunszain et al, 2013). These findings suggest a link between depression and adult neurogenesis in the hippocampus and, as discussed previously, many antidepressants repress the activation of FoxO.…”

Section: Foxos Play a Inhibitory Role In Neurogenesis And Synaptogenesissupporting

confidence: 60%

“…FoxOs are under the control of neurotransmitters (Liang et al, 2006) and glucocorticoids (Qin et al, 2014). FoxOs also regulate signals for cellular atrophy (Jaitovich et al, 2015), cellular morphology (Aranha et al, 2009) and adult neurogenesis and all of these physiological or pathological conditions contribute to the development of depression (Borre et al, 2014;Mahar et al, 2014;Anacker et al, 2013). Although the role of FoxOs in the process of depression is only beginning to be unveiled, it is reasonable at this time to hypothesize that FoxO transcription factors will be found to be pivotal mediators in psychiatric disorders.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…Diathesis interacts with the subsequent stress response of an individual, especially some early life experiences which are known to increase the risk for depression (Kiejna et al, 2010). Antidepressants initially correct imbalances of neurotransmitters in the synapse cleft (Mahar et al, 2014;Werner and Coveñas, 2013), while the therapeutic response may result from above and the downstream adaptive changes that occur as a consequence of increased neuroplasticity. These subcellular events include synaptic transmission, gene expression, neuronal morphological changes and many other molecular events in the brain (Kavalali and Monteggia, 2012;Pilar-Cuéllar et al, 2012;Seo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Forkhead box O transcription factors as possible mediators in the development of major depression

et al. 2015

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Section: Foxos Play a Inhibitory Role In Neurogenesis And Synaptogenesissupporting

confidence: 60%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Forkhead box O transcription factors as possible mediators in the development of major depression

et al. 2015

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“…On the other hand, other studies show evidence that high level of chronic stress causes depression basically because of monoaminergic changes that are generated in various brain regions and the suppression of hippocampal neurogenesis [19]. This neuronal degeneration could also affect the limbic…”

Section: Psychological and Emotional State In Ad: Well-being Perceivedmentioning

confidence: 99%

Role of Stress, Immune System and Well-being in Patients with Alzheimer's Disease

Mp¹,

M²,

Je³

2017

J Neurol Neurosci

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Alzheimer's disease (AD) is a progressive and neurodegenerative disorder that induces neuropsychiatric symptoms, disability, caregiver burden, and premature death in patients who suffer from it. It represents the most prevalent cause of dementia in our society and its incidence rates exponentially increase with age. Currently, this disorder does not have any cure and it is essential to know all the variables and factors involved in the development of this disorder. Among these factors, there are different categories such as biological and environmental aspects. It seems that the immune system (IS) and the stress system are some of them and the knowledge about their role in this disorder is an important question in this area. Moreover, it has been demonstrated that both systems are related and this relationship can also be influenced by the emotional system. In fact, the levels of the IS biomarker (immunoglobulin A) and the stress system (cortisol) are different in people with and without AD and IgA is higher in patients with high wellbeing. Therefore, the new therapies in AD should be focused on the influence of these systems and on postulating new alternative perspectives like non-pharmacological therapies.All this is essential for the study of AD in order to improve the quality of life in these patients, as well as knowing all the variables involved, so as to generate new therapeutic targets in AD.

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“…Besides, serotonin has been showed to increase ERK activation and neurotrophines release via 5-HT 2A receptors (Hisaoka et al, 2007). Trophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) regulate neurogenesis and neuronal plasticity, which are also improved after antidepressant treatment (Mahar et al, 2014;Ruan et al, 2013). Thus, these data allow us to hypothesise that antidepressant-like action of F-DPS might be due to phosphorylation of ERK via activation of serotonergic receptors leading to neurotrophic factors expression/release.…”

Section: Ctrlmentioning

confidence: 99%

ERK1/2 phosphorylation is involved in the antidepressant-like action of 2,5-diphenyl-3-(4-fluorophenylseleno)-selenophene in mice

Gai

Sanna

Stein

et al. 2014

European Journal of Pharmacology

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a b s t r a c tWe investigated the antidepressant-like action of 5 compounds belonging to the selenophene class. The involvement of ERK and CREB activation in this action was also demonstrated. In the experiment 1, timecourse and dose-response effect of H-DPS, CH 3 -DPS, Cl-DPS, F-DPS and CF 3 -DPS were accompanied in the mouse forced swimming test (FST). Firstly, animals received compounds at a dose of 50 mg/kg, by intragastric (i.g.) route, at different times (15-240 min) before test. Results showed that the peak of maximum anti-despair behavior induced by Cl-DPS, F-DPS and CF 3 -DPS was at 30 min; maximum effect of H-DPS and CH 3 -DPS was found at 60 min, which was maintained until 120 min. Regarding doseresponse effect, all compounds reduced immobility time and increased latency for the first episode of immobility at a dose of 50 mg/kg. In addition, F-DPS also showed antidepressant-like action at a dose of 25 mg/kg, whilst H-DPS, CH 3 -DPS, Cl-DPS and CF 3 -DPS were not effective at lower doses. Thus, F-DPS was chosen for further investigation of its mechanism of action. Experiment 2 showed that treatment of animals with F-DPS (50 mg/kg, i.g.) significantly increased phosphorylated ERK1/2 levels in the prefrontal cortex and hippocampus; however, pCREB levels were not affected. Additionally, in the experiment 3 anti-immobility effect of F-DPS was completely blocked by pretreatment of animals with PD 98,059, an inhibitor of ERK phosphorylation, suggesting that ERK signalling activation is involved in its antidepressant-like action in mice. Together our data appoint F-DPS as a promising molecule for the development of a new antidepressant therapy.

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Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Cited by 542 publications

References 326 publications

Forkhead box O transcription factors as possible mediators in the development of major depression

Forkhead box O transcription factors as possible mediators in the development of major depression

Role of Stress, Immune System and Well-being in Patients with Alzheimer's Disease

ERK1/2 phosphorylation is involved in the antidepressant-like action of 2,5-diphenyl-3-(4-fluorophenylseleno)-selenophene in mice

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