Stress response of fibroblasts adherent to the surface of plasma-treated poly(lactic-co-glycolic acid) nanofiber matrices

Plasma surface functionalization of biodegradable electrospun scaffolds for tissue engineering applications

“…Inversed gene expression levels was perceived on fibers having a WCA around 51 °. Therefore, a moderate hydrophilicity is favorable for the cells as it suppressed the cellular stress which was in accordance with an enhanced cell viability as shown by a dead/live staining assay [164].…”

Non-Thermal Plasma Surface Modification of Biodegradable Polymers

“…However, quite a few research articles deal with plasma modification of the copolymer PLGA (Khorasani et al, 2008, Hasirci et al, 2010, Khang et al, 2002, Park et al, 2007, Park et al, 2010, Safinia et al, 2007, Safinia et al, 2008, Shen et al, 2008, Wang et al, 2004. 50/50 PLGA films were modified in an oxygen plasma at low pressure and a decrease of the contact angle from 67° to below 40° after plasma treatment was observed.…”

Plasma Science and Technology - Progress in Physical States and Chemical Reactions

“…Almost all studies revealed an increase in initial adhesion and cell morphology and this for practically any cell-type tested (fibroblasts, osteoblasts, smooth muscle cells, stem cells, Schwann cells...), but some studies went into even more detail. Park et al [78] studied the adsorption of Bcl-2 proteins as a function of incorporated N-density on their e-spun PLGA scaffolds. Results showed that a mediocre hydrophilicity (WCA between 50° and 60°) resulted in the highest uptake of said protein.…”

“…Synthetic biodegradable polyesters such as PLA and PCL were often the material of choice for the fabrication of traditional and rapid prototyped scaffolds, and this is no different for the fabrication of electrospun materials. Several publications were published in the last 7 years where either PCL or PLA nanofibers were exposed to a plasma treatment [75][76][77][78][79][80][81][82][83][84]. Both lowpressure RF systems and atmospheric pressure plasma jets (APPJs) were used to generate plasma discharges using a variety of discharge gasses (air, NH 3 , Ar, N 2 + H 2 , O 2 , or a combination of those).…”