Stress-related preeclampsia: an evolutionary maladaptation in exaggerated stress during pregnancy?

Takiuti, Nilton Hideto; Kahhale, Soubhi; Zugaib, Marcelo

doi:10.1016/s0306-9877(02)00393-6

Cited by 14 publications

(9 citation statements)

References 31 publications

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“…It has been hypothesized that preeclampsia is, in part, a stress-related disease, and epidemiologic studies have shown that the relative risk for preeclampsia increases in relation to the number of stressful situations experienced 32 . Our findings suggest that psychological stress, in general or during pregnancy, is moderately associated with an increased risk of preeclampsia -- findings that are similar to previous studies 15,16,31 .…”

Section: Discussionmentioning

confidence: 99%

The combined association of psychosocial stress and chronic hypertension with preeclampsia

Zhang

Wang

et al. 2013

American Journal of Obstetrics and Gynecology

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OBJECTIVE This study aims to evaluate perceived lifetime stress (LS), perceived stress during pregnancy (PS), chronic hypertension (CH) and their joint association with preeclampsia risk. STUDY DESIGN This study includes 4,314 women who delivered a singleton live birth at the Boston Medical Center from October 1998 through February 2008. CH is defined as hypertension diagnosed before pregnancy. Information regarding LS and SP was collected by questionnaire. Preeclampsia was diagnosed by clinical criteria. RESULTS LS, SP and CH were each associated with an increased risk of preeclampsia (OR(95%CI)=2.1(1.6–2.8) for LS; 1.7(1.3–2.1) for SP; 11.1(8.1–15.4) for CH). Compared with normotensive pregnancy with low LS, both normotensive pregnancy with high LS (2.1(1.5–2.9)) and pregnancy with CH and low LS (10.6(7.5–15.1)) showed an increased risk of preeclampsia, while pregnancy with high LS and CH yielded the highest risk of preeclampsia (21.3(10.3–44.3)). The joint association of SP and CH on preeclampsia was very similar to that of the joint association of LS and CH. CONCLUSIONS This finding indicates that high psychosocial stress and CH can act in combination to increase the risk of preeclampsia up to 20-fold. This finding underscores the importance of efforts to prevent, screen and manage CH, along with reducing psychosocial stress, particularly among women with CH.

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Section: Discussionmentioning

confidence: 99%

The combined association of psychosocial stress and chronic hypertension with preeclampsia

Zhang

Wang

et al. 2013

American Journal of Obstetrics and Gynecology

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“…We found that stress, both at home and at work, had a significant impact on pre‐eclampsia in our study. Pre‐eclampsia has been hypothesised as a stress‐related disease and epidemiologic studies show that the relative risk for pre‐eclampsia is increased in many stressful situations 16 . Many risk factors for pre‐eclampsia are stress‐related 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Pre‐eclampsia has been hypothesised as a stress‐related disease and epidemiologic studies show that the relative risk for pre‐eclampsia is increased in many stressful situations 16 . Many risk factors for pre‐eclampsia are stress‐related 16 . Moderate/high physical activity at work is reported to be associated with a two times increase in the risk of severe pre‐eclampsia compared to mild activity 17 .…”

Section: Discussionmentioning

confidence: 99%

Risk factors for pre‐eclampsia in Lagos, Nigeria

Anorlu

Iwuala

Odum

2005

Aust NZ J Obst Gynaeco

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“…Women with partial HELLP syndrome (PHS) should be studied and managed separately from women with HELLP syndrome or severe preeclampsia. 15 The incidence of HELLP syndrome is 2 to 12%, 8,11,[16][17][18][19][20][21] while the incidence of PHS is unclear, but probably around 21 to 24%. 15,22 There is no information about PHS incidence in Brazil.…”

Section: Introductionmentioning

confidence: 99%