Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: A case-control study

Roca-Chiapas, José María De la; Solís, S.; Fajardo-Araujo, Martha Eugenia; Sosa, M.; Córdova–Fraga, Teodoro; Rosa-Zarate, Alma

doi:10.1016/j.jpsychores.2009.05.013

Cited by 53 publications

(49 citation statements)

References 67 publications

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“…[6][7][8][9] This association is probably derived from mutual and reciprocal interactions between the brain and the gut. 8,13 Corticotropin-releasing hormone (CRH), a major mediator of the stress response in the brain-gut axis, can increase intestinal permeability and lead to FD and IBS.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9] However, the association between the organic GI disorders and stress/depression is still unknown; except for a recent study, which reported that reflux esophagitis is associated with emotional stress. 10 The aim of our study was to investigate the effect of stress and depression on the prevalence of digestive diseases, including FD, IBS, reflux esophagitis, peptic ulcer disease (PUD), and adenoma and carcinoma of the stomach and colon.…”

Section: 3mentioning

confidence: 99%

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The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases

Lee

Sung

Kim

et al. 2015

J Neurogastroenterol Motil

146

104

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Background/AimsEpidemiological data indicate that emotional stress and depression might influence the development of gastrointestianl disorders and cancers, but the relationship between the two is still unclear. The aim was to investigate the effect of stress/depression on the prevalence of digestive diseases. In addition, we tried to identify whether stress and depression are risk factors for these diseases. MethodsA total of 23 698 subjects who underwent a medical check-up including upper and lower endoscopy were enrolled. By reviewing the subject's self-reporting questionnaire and endoscopic findings, we investigated the digestive diseases, including functional dyspepsia (FD), irritable bowel syndrome (IBS), reflux esophagitis, peptic ulcer disease, and adenoma and carcinoma of the stomach and colon. Stress and depression scores were measured by the Brief Encounter Psychosocial Instrument and Beck's Depression Inventory, respectively (Korean version). ResultsStress and depression were related to FD, IBS, and reflux esophagitis. Depression was also linked to peptic ulcer disease and adenoma/carcinoma of the colon and stomach. Multivariate analysis revealed that stress and depression were independent risk factors for FD (OR, 1.713 and 1.984; P ＜ 0.001) and IBS (OR, 1.730 and 3.508; P ＜ 0.001). In addition, depression was an independent risk factor for gastric adenoma/carcinoma (OR, 4.543; P ＜ 0.001). ConclusionsStress and depression are related to various digestive diseases, and they may be predisposing factors for FD and IBS. Depression may also be a cause of gastric cancer. Psychological evaluation of gastroenterology patients may be necessary, but more study is needed.

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Section: Discussionmentioning

confidence: 99%

Section: 3mentioning

confidence: 99%

The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases

Lee

Sung

Kim

et al. 2015

J Neurogastroenterol Motil

146

104

View full text Add to dashboard Cite

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“…In a cross-sectional study, 15 dyspepsia patients had significantly higher median stress scores than did controls on the basis of a stress profile test [18]. The 2547 individuals who fulfilled the ROME III criteria for functional dyspepsia or irritable bowel syndrome felt both more stressed and more susceptible to stress than did controls [1].…”

Section: Discussionmentioning

confidence: 96%

“…A Helicobacter pylori test is used to determine whether treatment should further include a course of two antibiotics (triple therapy) [5,8]. In scientific research, NSAIDs [3,9], exercise [1], peptic ulcer [3], age [3,[9][10][11][12][13], sex [1,[9][10][11]14,15], smoking [9,16], marital status [10], depression [9,11,13,17,18], sleep [1], BMI, and hypertension [9] have all been associated with dyspepsia. Psychological stress has been investigated as a risk factor for dyspepsia, with contradictory results.…”

Section: Introductionmentioning

confidence: 99%

Perceived stress as a risk factor for dyspepsia: a register-based cohort study

Deding

Torp‐Pedersen

Bøggild

2017

European Journal of Gastroenterology &Amp; Hepatology

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Objective Dyspepsia is a common condition and has a huge impact on quality of life and working capacity, but its causes are not well understood. An association between stress and dyspepsia has been debated for decades, but the issue has not been resolved. We examined the 3-year risk of redeeming a proton-pump inhibitor or an H2-receptor antagonist as a proxy of dyspepsia according to the level of perceived stress. Participants and methods Perceived stress was measured in a general health survey of 16 124 Danes aged older than 16 years of age in 2010 using Cohen’s Perceived Stress Scale. Data were linked individually to national registries, including the Danish National Prescription Registry. The risk of redeeming a proton-pump inhibitor or an H2-receptor antagonist for quintiles of stress level was estimated using Cox proportional hazard regression. Results In total, 2703 redeemed one of these drugs during the 33 months of follow-up. The cumulative incidence proportion of dyspepsia increased gradually, from 11.6 to 24.9%, with quintiles of stress. After full model adjustment, the four highest stress quintiles had a statistically significantly increased risk of redeeming a drug compared with the lowest stress quintile. The hazard ratios were 1.16 [95% confidence interval (CI): 1.00–1.34] for the second quintile, 1.21 (95% CI: 1.06–1.39) for the third quintile, 1.20 (95% CI: 1.05–1.38) for the fourth quintile, and 1.30 (95% CI: 1.12–1.50) for the fifth quintile. Conclusion Higher levels of self-reported perceived everyday life stress increased the risk of redeeming a drug for dyspepsia significantly during 33 months of follow-up.

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“…However, Vishnar et al 48 obtained rather contradictory results; the results showed that, except for anxiety, no significant association was found between the other disorders and non-ulcer dyspepsia. Also De la Roca-Chiapas et al 49 showed that depression was not outlined as a significant predictor of FD. High scores for neuroticism as well as an increased rate for somatization and social anxiety in FD patients was reported by Holtmann et al 50 We also found that the psychological profile was significantly associated with greater odds of bothersome postprandial fullness, early satiation, and epigastric pain.…”

Section: Discussionmentioning

confidence: 97%

Somatic Complaints Are Significantly Associated with Chronic Uninvestigated Dyspepsia and Its Symptoms: A Large Cross-sectional Population Based Study

Heidari

Keshteli

Feizi

et al. 2017

J Neurogastroenterol Motil

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Background/AimsSomatization may influence persistence and severity of symptoms in gastrointestinal diseases. Some studies suggest that somatization is associated with chronic uninvestigated dyspepsia (CUD); however, the association is unclear. We aimed to determine the association between the profiles of somatic complaints with CUD and its symptoms. MethodsIn a cross-sectional study conducted on 4763 Iranian adults, somatic complaints were assessed using a comprehensive 31-items questionnaire. Patients with CUD were identified by the Rome III diagnostic criteria. Profiles of somatic complaints were derived from factor analysis. Logistic regression analysis was used to assess the relationship between extracted profiles with CUD and its symptoms. ResultsCUD, bothersome postprandial fullness, early satiation, and epigastric pain or burning was identified in 723 (15.2%), 384 (8.1%), 302 (6.3%), and 371 (7.8%) of the study population. The frequency of all 31 somatic complaints was significantly higher in patients with CUD compared with controls (P < 0.001), and the most frequent was severe fatigue (45.1%). The profiles of somatic complaints were extracted in 4 domains, including "psychological", "gastrointestinal", "neuro-skeletal", and "pharyngeal-respiratory". The psychological (OR, 1.49; 95% CI, 1.44-1.54), gastrointestinal (OR, 2.22; 95% CI, 2.09-2.37), neuro-skeletal (OR, 1.52; 95% CI, 1.44-1.59), and pharyngeal-respiratory (OR, 2.09; 95% CI, 1.94-2.25) profiles were significantly associated with greater odds of CUD. ConclusionsCUD and its symptoms are strongly associated with higher levels of somatic complaints and their related extracted profiles. This perhaps explains that why it can be difficult to treat, however further prospective investigations are required to confirm these associations.

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Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: A case-control study

Cited by 53 publications

References 67 publications

The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases

The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases

Perceived stress as a risk factor for dyspepsia: a register-based cohort study

Somatic Complaints Are Significantly Associated with Chronic Uninvestigated Dyspepsia and Its Symptoms: A Large Cross-sectional Population Based Study

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