Somatic Complaints Are Significantly Associated with Chronic Uninvestigated Dyspepsia and Its Symptoms: A Large Cross-sectional Population Based Study

Heidari, Zahra; Keshteli, Ammar Hassanzadeh; Feizi, Awat; Afshar, Hamid; Adibi, Payman

doi:10.5056/jnm16020

Cited by 14 publications

(14 citation statements)

References 55 publications

(75 reference statements)

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“…The occurrence of PDS symptoms was in line with the frequency reported in previous studies ( 15 , 20 ). Furthermore, it has also been reported that patients with chronic uninvestigated dyspepsia have increased occurrence of joint and back pain ( 27 ), and therefore, it is conceivable that some of these patients might also have comorbid JHS.…”

Section: Discussionmentioning

confidence: 99%

Joint Hypermobility Syndrome in Patients With Functional Dyspepsia

Carbone

Fikree

Aziz

et al. 2020

Clin Transl Gastroenterol

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INTRODUCTION: The pathophysiology underlying functional dyspepsia (FD) is multifactorial and focuses on gastric sensorimotor dysfunction. Recent studies demonstrated that joint hypermobility syndrome (JHS) is strongly associated with unexplained dyspeptic symptoms in patients attending gastrointestinal clinics. We aimed to study the relationship between symptoms, gastric sensorimotor function, and JHS in FD patients. METHODS: Tertiary care FD patients who underwent a gastric barostat study and a gastric emptying breath test with 13C-octanoic acid were recruited for assessment of JHS. The presence of JHS was evaluated by a 2-phase interview and clinical examination that included major and minor criteria of the Brighton classification. RESULTS: A total of 62 FD patients (68% women, age 44 ± 1.8 years, and body mass index: 21.7 ± 0.7 kg/m 2 ) accepted to participate in the study. JHS was diagnosed in 55% of FD patients. Assessed symptom profiles during the visit did not differ between the groups. Delayed gastric emptying was not significantly more common in JHS group compared with non-JHS group (JHS group 32% vs non-JHS group 16%, P = 0.31). Prevalence of hypersensitivity to distention (JHS group 24% vs non-JHS group 29%, P = 0.76) and impaired gastric accommodation (JHS group 38% vs non-JHS group 42%, P = 0.79) was similar in patients with or without JHS. No correlations were found between the Beighton hypermobility score and gastric compliance ( r = 0.09). DISCUSSION: A large subset of this study cohort of tertiary care FD patients has coexisting JHS. We did not identify any specific differences in gastric sensorimotor function between patients with and without JHS. Further prospective research will be required to elucidate the relationship between JHS, a multisystemic disorder with widespread manifestations, and FD symptoms.

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Section: Discussionmentioning

confidence: 99%

Joint Hypermobility Syndrome in Patients With Functional Dyspepsia

Carbone

Fikree

Aziz

et al. 2020

Clin Transl Gastroenterol

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“…The factor scores for each profile were computed by summing up items of psychosomatic symptoms weighted by their factor loadings and assigned to each participant. More details about the results of factor analysis on psychosomatic symptoms are presented elsewhere [14,23]. In this study, quantitative and qualitative variables were expressed as mean (SD) and frequency (percentage), respectively.…”

Section: Discussionmentioning

confidence: 99%

“…We performed a separate mini survey on 100 randomly selected participants in order to assess the reliability of this questionnaire. There was a strong internal reliability based on Cronbach's alpha score of 0.903 [23].…”

Section: Assessment Of Psychosomatic/somatoform Symptomsmentioning

confidence: 99%

“…In the SEPAHAN project, a separate questionnaire was not available to assess psychosomatic symptoms; however, we found common items among questions contained in SEPAHAN's questionnaires with "the patient health questionnaire (PHQ)" [21] and "the 47-item questionnaire used in the Lacourt et al's study" [22] (as valid and standard tools for the assessment of psychosomatic symptoms), and established a validated questionnaire. This questionnaire includes 31 items divided into 4 domains (psychological (6 items), gastrointestinal (10 items), neuro-skeletal (9 items), and pharyngeal-respiratory (6 items)) [23]. It was used to evaluate the frequency of each psychosomatic symptom in the past 3 months experienced by study participants.…”

Section: Assessment Of Psychosomatic/somatoform Symptomsmentioning

confidence: 99%

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Psychosomatic complaints profile in patients with type 2 diabetes: a matched case-control study

Heidari

Feizi

Keshteli

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Objective: To compare the prevalence of psychosomatic symptoms and their mean scores of profiles in diabetic patients and sample of sex-age-matched healthy controls. Methods: This case-control study was conducted on 87 patients with type 2 diabetes. The control group consisted of 259 age-and gender-matched healthy participants. Psychosomatic symptoms were assessed using a comprehensive 31-item questionnaire, and psychological problems were evaluated by 12-item General Health Questionnaire and Hospital Anxiety and Depression Scale. Factor analysis, independent Student's t test, analysis of variance, and chi-square test were used for analyzing of data. Results: The frequency of 18 psychosomatic symptoms was significantly higher in diabetic patients with psychological problems compared with controls (P < 0.05), and the most frequent were "severe fatigue" (54.3%), "feeling low on energy" (48.6%), "disturbing thoughts" (45.7%), "pain in the joints" (34.3%), and "eyesore" (32.4%). There were significant differences in terms of "psycho-fatigue" (P ≤ 0.0001), "gastrointestinal" (P = 0.018), "neuroskeletal" (P = 0.001), and "pharyngeal-respiratory" (P = 0.009) profiles between studied groups. Conclusions: In conclusion, diabetic patients with psychological problems had a higher frequency of psychosomatic symptoms and also higher scores of psychosomatic disorder profiles than control participants. However, further prospective investigations are required to assess whether the psychosomatic disorder/symptom pattern was caused by conditions of diabetes disease.

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“…However, we settled a validated questionnaire based on 31 items in SEPAHAN's questionnaires common with the 47-items questionnaire used in the Lacourt et al's study (29), and "the patient health questionnaire (PHQ)" (30) as valid and standard tools for the assessment of somatoform symptoms. The reliability of this instrument has been evaluated previously (31) and showed a strong internal reliability with a Cronbach's alpha score of 0.903. The 31-items questionnaire was used to examine the frequency of somatoform symptoms.…”

Section: Assessment Of Somatoform Symptomsmentioning

confidence: 99%

The Association between Dietary Diversity Score and Somatoform Complaints Profile among Iranian Adults

Keshteli¹,

Mohammadi²,

Yahay³

et al. 2020

Preprint

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Background: The present study aimed to investigate the association between dietary diversity score (DDS) and somatoform complaints profile.Methods: The current cross-sectional study was conducted on 2818 adults aged 19-65 years working in Isfahan province, Iran. A Dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ) was used to collect dietary intake of participants. Somatoform symptoms were assessed using a validated comprehensive 31-items questionnaire.Results: After adjusting for the impacts of various confounders it was revealed that lower DDS is associated with higher risk of experiencing greater scores of psychological (OR=1.44, 95% CI: 1.06, 1.95; P=0.029) and pharyngeal-respiratory (OR=1.54, 95% CI: 1.17, 2.04; P=0.009) somatoform complaints. No significant association was found between DDS and neuro-skeletal and gastrointestinal somatoform complaints. In addition, stratified analysis by sex indicated that the lower DDS increased the risk of higher scores of psychological (OR = 1.73, 95% CI = 1.17, 2.56; P = 0.02) and pharyngeal-respiratory (OR = 1.75, 95% CI = 1.22, 2.49, P = 0.007) somatic complaints in women, but not in men.Conclusion: Present study indicated that the lower DDS is associated with higher risk of psychological and pharyngeal-respiratory somatoform complaints. Future prospective studies and particularly clinical trials are warranted to confirm these findings.

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Somatic Complaints Are Significantly Associated with Chronic Uninvestigated Dyspepsia and Its Symptoms: A Large Cross-sectional Population Based Study

Cited by 14 publications

References 55 publications

Joint Hypermobility Syndrome in Patients With Functional Dyspepsia

Joint Hypermobility Syndrome in Patients With Functional Dyspepsia

Psychosomatic complaints profile in patients with type 2 diabetes: a matched case-control study

The Association between Dietary Diversity Score and Somatoform Complaints Profile among Iranian Adults

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