Stress: Its Effect on Interactions among Biogenic Amines and Role in the Induction and Treatment of Disease

Antelman, Seymour M.; Chiodo, Louis A.

doi:10.1007/978-1-4615-7178-0_5

Cited by 30 publications

(26 citation statements)

References 174 publications

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“…In this chronic state of behavioral activation, behavioral stereotypies appear along with hypervigilance and paranoia, suggesting that dopaminergic constraint is associated with anxiety and vigilance (Ellinwood 1967). The amphetamine evidence is consistent with the dopamine theory of schizophrenia, in which high dopamine levels are associated with symptoms such as autism, stereotyped self-verbalizations, and paranoia (Antelman & Chiodo 1984). Not extraversion.…”

supporting

confidence: 70%

Steps to a neurochemistry of personality

Lawrence¹,

Koepp²,

Gunn³

et al. 1999

Behav Brain Sci

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Extraversion has two central characteristics: (1) interpersonal engagement, which consists of affiliation (enjoying and valuing close interpersonal bonds, being warm and affectionate) and agency (being socially dominant, enjoying leadership roles, being assertive, being exhibitionistic, and having a sense of potency in accomplishing goals) and (2) impulsivity, which emerges from the interaction of extraversion and a second, independent trait (constraint). Agency is a more general motivational disposition that includes dominance, ambition, mastery, efficacy, and achievement. Positive affect (a combination of positive feelings and motivation) is closely associated with extraversion. Extraversion is accordingly based on positive incentive motivation.Parallels between extraversion (particularly its agency component) and a mammalian behavioral approach system based on positive incentive motivation implicate a neuroanatomical network and modulatory neurotransmitters in the processing of incentive motivation. A corticolimbic-striatal-thalamic network (1) integrates the salient incentive context in the medial orbital cortex, amygdala, and hippocampus; (2) encodes the intensity of incentive stimuli in a motive circuit composed of the nucleus accumbens, ventral pallidum, and ventral tegmental area dopamine projection system; and (3) creates an incentive motivational state that can be transmitted to the motor system.Individual differences in the functioning of this network arise from functional variation in the ventral tegmental area dopamine projections, which are directly involved in coding the intensity of incentive motivation. The animal evidence suggests that there are three neurodevelopmental sources of individual differences in dopamine: genetic, "experience-expectant," and "experience-dependent." Individual differences in dopamine promote variation in the heterosynaptic plasticity that enhances the connection between incentive context and incentive motivation and behavior.Our psychobiological threshold model explains the effects of individual differences in dopamine transmission on behavior, and their relation to personality traits is discussed.Keywords: behavioral sensitization; dopamine; extraversion; heterosynaptic plasticity; incentive motivation; neurobiology; personality the behavioral, emotional, and motivational characteristics of extraversion. Next, we identified a mammalian behavior pattern with corresponding characteristics, as described in the psychological and ethological literatures. Once an analogous motivation was identified, animal neurobiological research provided empirical links to its neural organization and neurochemical modulation. These hypotheses were then extended to humans and subjected to empirical tests. Extraversion: Central characteristics and underlying motivationExtraversion is a higher-order trait that is derived from a set of correlated lower-order traits. The lower-order traits are measures of behavioral and emotional characteristicssuch as social dominance, positive emo...

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supporting

confidence: 70%

Steps to a neurochemistry of personality

Lawrence¹,

Koepp²,

Gunn³

et al. 1999

Behav Brain Sci

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“…A large body of experimental evidence suggest that the mesolimbic DA neurons are involved in the organization and regulation of behaviors motivated by a wide range of reinforcers, including natural reinforcers and many drugs abused by humans (Abercrombie and Jacobs, 1985;Antelman and Chiodo, 1984;Blackburn et al, 1992;Damsma et al, 1992;Hernandez and Hoebel, 1988;Kiyatkin, 1988 b;Koob and Bloom, 1988;Le Moal and Simon, 1991;McCullough et al, 1993;Phillips etal., 1991;Salamone, 1992;Wise and Bozarth, 1987). If these behaviors all share the characteristic of being under mesolimbic DA control, then the changes in DA-dependent signals reported in the present study should be common to behaviors motivated by other types of reinforcers.…”

Section: Resultsmentioning

confidence: 98%

Behavioral significance of phasic changes in mesolimbic dopamine-dependent electrochemical signal associated with heroin self-injections

Kiyatkin

1994

J. Neural Transmission

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High-speed chronoamperometry with monoamine-selective carbon fiber electrodes was used in rats to monitor, during 5-6 consecutive daily sessions, changes in DA-dependent electrochemical signal in the nucleus accumbens (NAcc) during intravenous heroin (0.1 mg/kg) self-administration (SA) behavior and passive repeated drug injections performed with a temporal scheme similar to that in the SA experiment. In trained animals, biphasic signal fluctuations time-locked to the individual lever-presses were found to accompany all but the first daily SAs. The signal gradually increased by 30-40 nM for the 10 minutes preceding the SA, reached a peak at the moment of lever-press and decreased abruptly by approximately 40 nM for 3-4 min after heroin SA. The cycle then repeated, reaching a new peak at the moment of the next lever-press. Rapid bi-directional fluctuations in signal associated with individual heroin SAs were superimposed on substantial tonic increase in signal baseline (400-500 nM). This increase quickly developed after presentation of heroin-related light cue and the first SA, was relatively stable during all subsequent SAs and decreased towards the baseline after the last SA of a session. Changes in signal baseline induced by repeated heroin SAs depended strongly upon the signal's basal level (r = -0.787); that signal preferentially increased when its basal values were low (0-300 nM), and decreased when signal was tonically elevated (> 600 nM). Repeated passive heroin injections also induced biphasic signal fluctuations and a similar tonic increase in signal baseline. Although a transient signal decrease (25 nM for 2-4 minutes) followed by a prolonged signal increase occurred after each but not the first passive injection, the gradual pre-injection signal acceleration was absent. Although DOPAC, a principal DA metabolite, may significantly contribute to the tonic increase in electrochemical signal seen during SA session, the changes in extracellular DA may be the main contributor to both the rapid signal increases preceding drug-taking and the transient signal decreases following heroin SA. If so, the present findings suggest that activation of mesolimbic DA cells and increase in DA transmission may be involved in the mediation of motivational and/or activational components of drug-seeking and drug-taking behavior. An acute termination of previous drug- and behavior-associated DA activation with a transient inhibition of DA release, immediately following heroin SA may correlate with the drug's rewarding action, representing a part of a mechanism regulating drug-taking behavior.

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“…З точки зору сучасної фізіології стрес -це неспецифічна реакція організму у відповідь на надпорогові подразники, що запускає ме-ханізми адаптації до змінених умов існування [5]. Індивідуальну адаптацію визначають як набуття стійкості до певних чинників довкілля внаслідок чого організм отримує можливість пристосуватись до нових умов.…”

Section: вступunclassified

“…

Стрес-реакція відіграє провідну роль у фор-муванні системного структурного «сліду» за пристосування до факторів навколишнього середовища, а потім, з розвитком стійкої адаптації, стає зайвою і згасає [6,7].

…”

unclassified

Antioxidant-Prooxidant Status in Organism of Pigs With Different Types of Higher Nervous Activity Under Stress

Данчук¹,

Karpovskyi²,

Трокоз³

2018

Fiziol Zh

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З точки зору сучасної фізіології стрес -це неспецифічна реакція організму у відповідь на надпорогові подразники, що запускає ме-ханізми адаптації до змінених умов існування [5]. Індивідуальну адаптацію визначають як набуття стійкості до певних чинників довкілля внаслідок чого організм отримує можливість пристосуватись до нових умов.Стрес-реакція відіграє провідну роль у фор-муванні системного структурного «сліду» за пристосування до факторів навколишнього середовища, а потім, з розвитком стійкої адаптації, стає зайвою і згасає [6,7]. Ще Сельє звернув увагу на те, що перші прояви різноманітних інфекцій абсолютно однакові. Він припустив, що кожен хвороботворний фактор має своєрідний «пусковий» механізм для загального адаптаційного синдрому [8]. В умовах стресу зростає рівень радикалоут-ворення, що призводить до інтенсифікації ПОЛ [9,10]. Поняття окисного стресу виз-начає дисбаланс у анти-, прооксидантній системі, що супроводжується накопиченням у клітинах та тканинах продуктів ПОЛ на тлі зниженої активності антиоксидантних ензимів [7,11,12].

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Stress: Its Effect on Interactions among Biogenic Amines and Role in the Induction and Treatment of Disease

Cited by 30 publications

References 174 publications

Steps to a neurochemistry of personality

Steps to a neurochemistry of personality

Behavioral significance of phasic changes in mesolimbic dopamine-dependent electrochemical signal associated with heroin self-injections

Antioxidant-Prooxidant Status in Organism of Pigs With Different Types of Higher Nervous Activity Under Stress

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