Antioxidant-Prooxidant Status in Organism of Pigs With Different Types of Higher Nervous Activity Under Stress

Данчук, О.; Karpovskyi, V. І.; Трокоз, В. О.

doi:10.15407/fz64.04.026

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…In weaned piglets and adult pigs, lower oral doses of micellar α-tocopherol showed a better effect than any other form of the vitamin [183]. Feeding a julep containing the micellar form of vitamin E to fattening piglets and pigs prevented the consequences of technological stress and increased activity of the antioxidant protection system and general resistance of the animals [184].…”

Section: Application Of Nanotechnology To Increase Productivity and P...mentioning

confidence: 94%

“…For example, Zn-based NPs were used to fortify weaning piglets and to improve their digestion and productivity [185,201,202], especially as an alternative to the mineral zinc oxide [203]. In particular, the administration of nanoformulated Mg, Zn, Ge, and Ce feed additives to pigs increased the activity of their antioxidant defense system, stress resistance, and productivity [184].…”

Section: Application Of Nanotechnology To Increase Productivity and P...mentioning

confidence: 99%

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Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine

Danchuk,

Levchenko,

da Silva Mesquita

et al. 2023

Pharmaceutics

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In recent decades, nanotechnology has been rapidly advancing in various fields of human activity, including veterinary medicine. The review presents up-to-date information on recent advancements in nanotechnology in the field and an overview of the types of nanoparticles used in veterinary medicine and animal husbandry, their characteristics, and their areas of application. Currently, a wide range of nanomaterials has been implemented into veterinary practice, including pharmaceuticals, diagnostic devices, feed additives, and vaccines. The application of nanoformulations gave rise to innovative strategies in the treatment of animal diseases. For example, antibiotics delivered on nanoplatforms demonstrated higher efficacy and lower toxicity and dosage requirements when compared to conventional pharmaceuticals, providing a possibility to solve antibiotic resistance issues. Nanoparticle-based drugs showed promising results in the treatment of animal parasitoses and neoplastic diseases. However, the latter area is currently more developed in human medicine. Owing to the size compatibility, nanomaterials have been applied as gene delivery vectors in veterinary gene therapy. Veterinary medicine is at the forefront of the development of innovative nanovaccines inducing both humoral and cellular immune responses. The paper provides a brief overview of current topics in nanomaterial safety, potential risks associated with the use of nanomaterials, and relevant regulatory aspects.

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Section: Application Of Nanotechnology To Increase Productivity and P...mentioning

confidence: 94%

Section: Application Of Nanotechnology To Increase Productivity and P...mentioning

confidence: 99%

Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine

Danchuk,

Levchenko,

da Silva Mesquita

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

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“…In the second stage, venous blood was taken from each 35-day-old animal after a 2-hour fasting diet from the axillary vein. The content of lipid peroxidation products (ketodienes, Schiff bases, diene conjugates) was determined in the blood plasma by spectrophotometric method, the principle of which is based on the fact that the process of lipid peroxidation is accompanied by reorientation of double bonds with the appearance of specific optical properties (Kondrakhin et al, 2004;Danchuk et al, 2018). The level of tocopherol assessed the activity of the non-enzymatic part of the antioxidant system in blood plasma by liquid chromatography of vitamins extracted from biological fluids (Vlislo, 2012).…”

Section: Materials and Research Methodsmentioning

confidence: 99%

Autonomous regulation of antioxidant protection and protein exchange in chickens

Shnurenko¹,

Studenok²,

Karpovskyi³

et al. 2021

SMLNUVMB

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The tone of the autonomic nervous system, protein metabolism and the activity of the antioxidant system in Cobb-500 cross chickens aged 35 and 60 days were researched. The experiment involved 24 chickens, 8 in each group. In birds, the tone of the autonomic nervous system was determined by the method of variation pulsometry by recording the influence of the sympathetic and parasympathetic systems on the heart rate in chickens. The effect was determined by counting one hundred consecutive cardio intervals and the time interval between each cardiocycle. Venous blood samples were taken from each individual at the age of 35 and 60 days to determine protein metabolism (total protein, albumin, globulins), enzymatic and non-enzymatic links of the antioxidant system and lipid peroxidation depending on the tone of the autonomic nervous system. It was found that the antioxidant level in chickens with a predominance of the sympathetic division prevailed in all other groups regardless of the age of the bird. At 35 days of age, plasma concentrations of diene conjugates were significantly higher in normatonics and vagotonics (P ˂ 0.05). There was a higher level of activity of ketodienes and Schiff bases in chickens with a predominance of the sympathetic division of autonomic nervous regulation compared with normotonics and vagotonics (P ˂ 0.01). The content of total protein, albumin and globulins prevailed in normotonic hens and was the lowest in vagotonic hens at the age of 35 days. The two-month-old bird with a dominant parasympathetic division of the autonomic nervous system and normotonic hens had the highest levels of total protein, globulins, and conversely, sympathicotonic hens outnumbered the latter in albumin levels. Histidine content was highest in chickens with a balanced type of autonomic nervous system compared to sympathicotonics and vagotonics (P ˂ 0.05). The concentration of sulfur-containing amino acid methionine was highest in vagotonic chickens (P < 0.05) compared with sympathicotonics. Threonine was highest in sympathicotonics compared with other groups of animals and significantly outweighed vagotonics (P < 0.05). The level of lipid peroxidation products in 60-day-old sympathicotonic chickens was consistently higher in contrast to normotonics and vagotonics. At the same time there was the smallest increase in the activity of diene conjugates and ketodienes (P < 0.05) in chickens with a dominant sympathetic division of the autonomic nervous system, which indicates a slowdown in the accumulation of the final products of lipid peroxidation. It was found that the predominance of sympathetic tone is characterized by low activity of enzymes of the antioxidant system and tocopherol (P < 0.001, P < 0.01) at 35 and 60 days of age. Indicators of the activity of the antioxidant system had the highest level in vagotonic chickens of the studied age period (P < 0.05, P < 0.01, P < 0.001). The relationship between catalase and tocopherol levels in vagotonic chickens at 35 days of age, which increases at 60 days of age r = 0.53 (P < 0.01) was found.

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“…На другому етапі у кожної тварини 35-добового віку відбирали венозну кров після 2-годинної голодної дієти з підкрилової вени. В плазмі крові визначали вміст продуктів пероксидного окислення ліпідів (ке-тодієни, основи Шиффа, дієнові кон'югати) спектрофотометричним методом, принцип якого базується на тому, що процес пероксидного окиснення ліпідів супроводжується переорієнтацією подвійних зв'язків із виникненням специфічних оптичних властивостей (Stalnaya, 1977;Kondrakhin et al, 2004;Khuzhakhmetova & Teply, 2016;Danchuk et al, 2018). У сироватці крові визначали вміст загального білка (біуретовим методом) та альбуміну (методом з бромкрезоловим зеленим) на напівавтоматичному біохімічному аналізаторі BiosystemsA15 (Іспанія) з використанням набору реактивів PointerScientific (США).…”

Section: матеріал і методи дослідженьunclassified

Indicators of protein metabolism and intensity of lipid peroxide oxidation in chickens with different vegetative status

et al. 2021

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The tone of the autonomic nervous system, protein metabolism and enzymes in Cobb-500 crossbred chickens aged 35 and 60 days were studied. The experiment involved 24 chickens, 8 in each group. In birds, the tone of the autonomic nervous system was determined by the method of variation pulsometry. The essence of the method is to record the effect of sympathetic and parasympathetic systems on heart rate in chickens. The effect was determined by recording one hundred consecutive cardio intervals and counting the time interval between each cardiocycle. Venous blood samples were taken from each individual at the age of 35 and 60 days to determine the indicators of protein metabolism (total protein, albumin, globulins) and lipid peroxidation depending on the tone of the autonomic nervous system. It was found that the antioxidant level in chickens with a predominance of the sympathetic division prevailed in all other groups regardless of the age of the bird. At 35 days of age, plasma concentrations of diene conjugates were significantly higher in normatonics and vagotonics (P ˂ 0.05). There was a higher level of activity of ketodienes and Schiff bases in chickens with a predominance of the sympathetic division of autonomic nervous regulation compared with normotonics and vagotonics (P ˂ 0.01). The content of total protein, albumin and globulins prevailed in normotonic hens and was the lowest in vagotonic hens at the age of 35 days. The two-month-old bird with a dominant parasympathetic division of the autonomic nervous system and normotonic hens had the highest levels of total protein, globulins, and conversely, sympathicotonic hens outnumbered the latter in albumin levels. Histidine content was highest in chickens with a balanced type of autonomic nervous system compared to sympathicotonics and vagotonics (P ˂ 0.05). The concentration of sulfur-containing amino acid methionine was highest in vagotonic chickens (P < 0.05) compared with sympathicotonics. Threonine was highest in sympathicotonics compared with other groups of animals and significantly outweighed vagotonics (P < 0.05). The level of lipid peroxidation products in 60-day-old sympathicotonic chickens was consistently higher in contrast to normotonics and vagotonics. At the same time there was the smallest increase in the activity of diene conjugates and ketodienes (P < 0.05) in chickens with a dominant sympathetic division of the autonomic nervous system, which indicates a slowdown in the accumulation of the final products of lipid peroxidation.

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Antioxidant-Prooxidant Status in Organism of Pigs With Different Types of Higher Nervous Activity Under Stress

Cited by 5 publications

References 7 publications

Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine

Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine

Autonomous regulation of antioxidant protection and protein exchange in chickens

Indicators of protein metabolism and intensity of lipid peroxide oxidation in chickens with different vegetative status

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