Stress-Induced Modulation of the Immune Response

Monjan, Andrew A.; Collector, Michael I.

doi:10.1126/science.557841

Cited by 437 publications

(124 citation statements)

References 14 publications

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“…Various stress impact is commonly followed by a proliferation decrease (Monjan and Collector 1977, Hoffman-Goetz et al 1986, Odio et al 1986, Rabin and Salvin 1987. In our study the indications for a decrease of T-lymphocyte proliferation with ConA in the stressed animals and their progeny were found (Table 4).…”

Section: Discussionsupporting

confidence: 56%

“…However, there are some data showing that a noise can lead to a decrease of B-cell proliferation with LPS (Monjan and Collector 1977). It has been found that various stress impact could lead to a suppression of B-cell activity and to a decrease in number of the antibody forming cells (Gisler 1974, Boranic et al 1984, Esterling and Rabin 1987, Keller et al 1988, Kirillina et al 1989.…”

Section: Discussionmentioning

confidence: 99%

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Social stress in laboratory rats Rattus norvegicus results in decreased immune competence of the offspring

Пронин¹,

Николаева²,

Deyeva³

et al. 1997

Acta Theriol.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Social stress in laboratory rats Rattus norvegicus results in decreased immune competence of the offspring

Пронин¹,

Николаева²,

Deyeva³

et al. 1997

Acta Theriol.

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“…One of the key causal mechanisms of this relationship is thought to be the general catabolic influence of high circulating cortisol on certain muscle types and fat cells (Sapolsky et al, 2000;Yoshioka et al, 2005). Overall health indicators were also assessed, as chronic stress is known to have a generally suppressive effect on the immune system (Monjan and Collector, 1977;Jasnow et al, 2001;Kanitz et al, 2004). Again, this association is mediated, at least in part, by glucocorticoids (Chrousos, 1995).…”

Section: Introductionmentioning

confidence: 99%

The impact of chronic environmental stressors on growing pigs, Sus scrofa (Part 1): stress physiology, production and play behaviour

O’Connor

Parker

McLeman

et al. 2010

Animal

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Commercially farmed animals are frequently housed in conditions that impose a number of concurrent environmental stressors. For pigs housed indoors, elevated levels of mechanical noise, atmospheric ammonia and low light intensities are commonplace. This experiment examined the effects on growing pigs of chronic exposure to combinations of commercially relevant levels of these potential stressors. Four-week-old hybrid female pigs (n 5 224) were housed under experimentally manipulated conditions of nominally either ,5 or 20 ppm atmospheric concentration of ammonia (24 h), a light intensity of 40 lux or 200 lux (12 h) and mechanical noise at either <60 or 80 dB(A) (24 h) for 15 weeks in a fully factorial arrangement (2 3 ) of treatments. The response of pigs to these environmental factors was assessed using a suite of physiological, production and behavioural measures. These included indicators of hypothalamic-pituitary-adrenal (HPA) axis activation such as salivary cortisol and adrenal morphometry, as well as body weight, food conversion efficiency and general health scores. Play behaviour was recorded as it is thought to be inversely related to stress. Chronic exposure to ammonia produced the strongest effect, shown by lower concentrations of salivary cortisol and larger adrenal cortices in the pigs reared under 20 ppm ammonia, which may have been indicative of a period of HPA activation leading to a downregulation of cortisol production. The pigs in the ammoniated rooms also performed less play behaviour than pigs in non-ammoniated rooms. There was evidence for an interaction between high noise and ammonia on the health scores of pigs and for brighter light to ameliorate the effect of ammonia on salivary cortisol. However, there was no measurable impact of these potential stressors on the productivity of the pigs or any of the other physiological parameters measured. We conclude that there should be little concern in terms of performance about the physical stressors tested here, within current European Union legal limits. However, 20 ppm ammonia may have had an adverse influence on the well-being of growing pigs. In this study, all other aspects of the pigs' husbandry were optimal; therefore, it is possible that under less favourable conditions, more pronounced effects of ammonia, noise and dim light would be observed.

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“…In animals, acute exposure to electric shocks (Keller, Weiss, Schleifer, Miller, & Stein, 1983), social defeat (Fleshner, Laudenslager, Simons, & Maier, 1989; review by Bohus & Koolhaas, 1991), maternal separation (Coe, Rosenberg, & Levine, 1988;Laudenslager, Held, Boccia, Reite, & Cohen, 1990), rotation (Esterling & Rabin, 1987)), the odor of a stressed conspecific (Zalcman, Richter, & Anisman, 1989), immersion in cold water (Jiang, MorrowTesch, Beller, Levy, & Black, 1990), restraint (Bonneau, Sheridan, Feng, & Glaser, 1991a, 1991b, handling (Moynihan et al, 1990), intraperitoneal injection of saline (Moynihan, Koota, Brenner, Cohen, & Ader, 1989), and loud noise (Monjan & Collector, 1977) have all been shown to suppress some aspect of immunity. Chronic stressors such as crowding (Rabin, Lyte, Epstein, & Caggiula, 1987) have also been examined.…”

Section: Stress and Immunitymentioning

confidence: 99%

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Maier¹,

Watkins²,

Fleshner³

1994

American Psychologist

323

168

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Psychoneuroimmunology is the study of interactions between behavior, the brain, and the immune system. This article is designed to provide an overview of this new field for the general psychologist. The existence of bidirectional communication pathways between the brain and the immune system and the implications of this network for behavior are emphasized. Implications are that behavioralpsychological processes ought to be capable of altering immune function and that events that occur as part of immune responses should modulate behavior. Evidence for influences in both of these directions is reviewed. The discussion of psychological modulation of immunity focuses on classical conditioning and stress, whereas that of immune modification of behavior highlights behavioral effects produced by substances released by the immune system. Finally, the adaptive role that such changes might play is considered. Lyle E. Bourne served as action editor for this article.

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Stress-Induced Modulation of the Immune Response

Cited by 437 publications

References 14 publications

Social stress in laboratory rats Rattus norvegicus results in decreased immune competence of the offspring

Social stress in laboratory rats Rattus norvegicus results in decreased immune competence of the offspring

The impact of chronic environmental stressors on growing pigs, Sus scrofa (Part 1): stress physiology, production and play behaviour

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

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