Stress hyperglycemia and acute ischemic stroke in-hospital outcome

Τζιόμαλος, Κωνσταντίνος; Dimitriou, P.; Bouziana, Stella D.; Spanou, Marianna; Kostaki, Stavroula; Angelopoulou, Stella-Maria; Papadopoulou, Maria; Giampatzis, Vasilios; Savopoulos, Christos; Hatzitolios, Apostolos

doi:10.1016/j.metabol.2016.11.011

Cited by 76 publications

(92 citation statements)

References 32 publications

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“…17 In the Tziomalos et al, in 2016, there was a significant association between hyperglycemia in ischemic stroke patients with diabetes and non-diabetes in the NIHSS (P<0.001). 18 In this study there was no significant difference between hyperglycemia in ischemic stroke patients with diabetes and non-diabetes in mRS H1 (PR 1.5; 95% CI, 0.413-5.450; P=0.657). In the study of Marulaiah et al, in 2017, there was no significant association between hyperglycemia in ischemic stroke patients with diabetes and non-diabetes in mRS (P=0.09).…”

Section: Discussioncontrasting

confidence: 56%

The effect of hyperglycemia and troponin I levels on the prognosis of acute ischemic stroke in non-diabetic and diabetic patients

Lubis¹,

Anwar²,

Arina³

2019

Int J Res Med Sci

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Background: Acute hyperglycaemia may predict a higher risk of hospitalization mortality after ischemic stroke in non-diabetic patients and a higher risk of poor functional improvement in non-diabetic stroke patients. It is thought that insula involvement in right cerebral hemispheres has a role in autonomic control of the heart. Troponin is a sensitive marker that is widely used in the diagnosis and risk stratification of acute coronary syndrome. High troponin I is found in acute stroke patients and is associated with a poorer prognosis.Methods: The study was cross-sectional, 30 patients diagnosed with acute ischemic stroke at Haji Adam Malik General Hospital Medan from June 16, 2017 to March 31, 2018. All participants were taken blood to measure blood glucose levels at the time of admission >140 mg/dL with a history of previous or not diabetes. Troponin I levels was checked when acute ischemic stroke patients had entered the inpatient room. The patient's prognosis is determined by National Institute of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS). The calculation of NIHSS and MRS scores was performed on the first day of admission and the fourteenth day after being admitted to the hospital. Statistical test using Fisher exact test.Results: Of the 30 samples consisted of 19 men and 11 women. The significant effect between hyperglycaemia in acute ischemic stroke patients with diabetes and non-diabetes on the fourteenth day NIHSS (PR 2.8; 95% CI, 1.184-6,622; p=0.045).Conclusions: There was an effect between hyperglycaemia in non-diabetic and diabetic on the poor prognosis of acute ischemic stroke patients.

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Section: Discussioncontrasting

confidence: 56%

The effect of hyperglycemia and troponin I levels on the prognosis of acute ischemic stroke in non-diabetic and diabetic patients

Lubis¹,

Anwar²,

Arina³

2019

Int J Res Med Sci

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“…In contrast, two prospective observational studies did not find a direct relationship between stress hyperglycemia and poorer stroke outcomes, but found that stress hyperglycemia was associated with more severe stroke and rather the severity of the stroke that led to poorer outcomes.…”

Section: Discussionmentioning

confidence: 83%

“…Geographically, the mean prevalence of diabetes in stroke inpatients was highest in Southeast Asian (Singapore, India, Indonesia) and East Asian countries (China, Japan, Taiwan), which were 33.5 and 32.3%, respectively, and mostly in Taiwan. The mean prevalence in studies from North America and Europe was 27.5 and 26.4%, respectively. Only one study in the Middle East estimated a prevalence of 36%.…”

Section: Resultsmentioning

confidence: 96%

Prevalence of diabetes and its effects on stroke outcomes: A meta‐analysis and literature review

Lau

Lew

Borschmann

et al. 2018

J of Diabetes Invest

299

205

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“…[30] and adds insights to the relative influence of stroke severity and hyperglycemia on clinical and neurological outcomes following stroke occurrence [31]. Even though most studies have shown that hyperglycemia at admission confers a worse prognosis following acute stroke, it is still unclear whether it only reflects stroke severity or it is directly associated with outcomes [2] [32]. Although some studies have suggested acute hyperglycemia as a marker of stroke severity, the majority of basic science research support the theory that hyperglycemia at admission leads to worsened outcomes through its direct toxic effects on the brain tissue (in particular to the vulnerable ischemic penumbra) possibly because of the accumulation of lactic acid secondary to anaerobic metabolism, enhanced excitatory neurotransmitter (glutamate, aspartate) release, and increased cerebral edema [2] [33].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Signification of Admission Hyperglycemia among Acute Stroke Patients in Intensive Care Units in Kinshasa, the Democratic Republic of the Congo

Tshituta¹,

Lepira²,

Kajingulu³

et al. 2019

WJCD

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BACKGROUND AND AIM: Although admission hyperglycemia has been reported to be associated with unfavorable outcomes in acute stroke, little is known about this association in sub-Saharan Africa. Therefore, the aim of the present study was to assess the prognostic significance of admission hyperglycemia in the acute phase of stroke in Congolese patients. METHODS: In a multicenter prospective cohort study, consecutive patients with acute stroke were examined in 5 Emergency Rooms or Intensive Care Units of Kinshasa between July 15 th , 2017 and March 15 th , 2018. The severity of stroke was assessed at admission using the Glasgow Coma Scale. Stress hyperglycemia was defined as random blood glucose levels at admission > 140 mg/dL in patients without known type 2 diabetes mellitus (T2DM). The endpoint was 10-day all-cause in-hospital mortality. Survival (time-to-death) curves were built using the Kaplan Meier methods. Cox proportional analysis was used to identify predictors of 10-day all-cause in-hospital mortality. The predictive performance of blood glucose level to predict 10-day all-cause in-hospital mortality was assessed using ROC curve analysis. RESULTS: Out of 194 patients (mean age 58.7 ± 13.1 years; 64% males, 74.7% light to moderate stroke severity; 63.4% ischemic stroke) enrolled, 106 (54.

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Stress hyperglycemia and acute ischemic stroke in-hospital outcome

Cited by 76 publications

References 32 publications

The effect of hyperglycemia and troponin I levels on the prognosis of acute ischemic stroke in non-diabetic and diabetic patients

The effect of hyperglycemia and troponin I levels on the prognosis of acute ischemic stroke in non-diabetic and diabetic patients

Prevalence of diabetes and its effects on stroke outcomes: A meta‐analysis and literature review

Prognostic Signification of Admission Hyperglycemia among Acute Stroke Patients in Intensive Care Units in Kinshasa, the Democratic Republic of the Congo

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