Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors

Pawluski, Jodi L.; Hove, Daniël L.A. van den; Rayen, Ine; Prickaerts, Jos; Steinbusch, Harry W.M.

doi:10.1016/j.yhbeh.2011.02.012

Cited by 66 publications

(79 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, these levels were not baseline levels and reflected corticosterone responses to a stressor. However, in agreement with previous work (Slattery and Neumann, 2008;Pawluski et al, 2011) we did find that pregnant females have decreased corticosterone levels, regardless of stress, when compared to virgin females. It is very likely that corticosterone plays an important role in the remodeling of dendritic trees (branch points and dendritic length) in pregnant and virgin rats, as higher free corticosterone levels are associated with pregnancy (Voogt et al, 1969;Atkinson and Waddell, 1995), as well as with stress (McEwen et al, 1993;Conrad, 2008).…”

Section: Effect Of Corticosterone On Dendritic Morphology In Pregnantsupporting

confidence: 93%

“…However, it has recently been shown that stress can alter hippocampal cell proliferation in late pregnant females (Pawluski et al, 2011) and c-fos expression is decreased in the CA3 region after acute stress in late pregnancy (Wartella et al, 2003). High levels of corticosterone, via injection, during gestation have also been shown to result in decreased hippocampal cell proliferation in the mother at weaning (Brummelte et al, 2006;Brummelte and Galea, 2010).…”

Section: Stress Results In Dendritic Remodeling Of Ca3 Pyramidal Neurmentioning

confidence: 99%

“…This is perhaps not surprising as previous studies have shown that stress has limited effects on weight gain in virgin and pregnant females (Dalla et al, 2005;Pawluski et al, 2011). However, others have reported higher body weights in the control group compared with the stress group (Galea et al, 1997;Darnaudery et al, 2004;van den Hove et al, 2005van den Hove et al, , 2010Baker et al, 2008).…”

Section: Repeated Stress Did Not Significantly Alter Body Weight In Pmentioning

confidence: 85%

“…Repeated restraint during gestation increases the number of proliferating cells in the subgranular zone of the dentate gyrus of late pregnant females (Pawluski et al, 2011), but does not affect hippocampal neurogenesis in the mother after weaning (Pawluski et al, 2012a). Acute restraint stress or exposure to a novel environment decreases c-fos expression in the CA3 region of the hippocampus in both pregnant and postpartum females (Wartella et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pregnancy or stress decrease complexity of CA3 pyramidal neurons in the hippocampus of adult female rats

et al. 2012

View full text Add to dashboard Cite

Section: Effect Of Corticosterone On Dendritic Morphology In Pregnantsupporting

confidence: 93%

Section: Stress Results In Dendritic Remodeling Of Ca3 Pyramidal Neurmentioning

confidence: 99%

Section: Repeated Stress Did Not Significantly Alter Body Weight In Pmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pregnancy or stress decrease complexity of CA3 pyramidal neurons in the hippocampus of adult female rats

et al. 2012

View full text Add to dashboard Cite

“…injection of BrdU (200 mg/kg; Sigma, St. Louis, MO) dissolved in 0.9 % saline as previously described (Pawluski and Galea 2007;Pawluski et al 2011). After BrdU injection, all animals were single housed with standard enrichment for the duration of the study (3 weeks).…”

Section: Methodsmentioning

confidence: 99%

Developmental exposure to SSRIs, in addition to maternal stress, has long-term sex-dependent effects on hippocampal plasticity

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Dynamics of olfactory and hippocampal neurogenesis in adult sheep

Brus

Meurisse

Gheusi

et al. 2012

J of Comparative Neurology

View full text Add to dashboard Cite

Although adult neurogenesis has been conserved in higher vertebrates such as primates and humans, timing of generation, migration, and differentiation of new neurons appears to differ from that in rodents. Sheep could represent an alternative model to studying neurogenesis in primates because they possess a brain as large as a macaque monkey and have a similar life span. By using a marker of cell division, bromodeoxyuridine (BrdU), in combination with several markers, the maturation time of newborn cells in the dentate gyrus (DG) and the main olfactory bulb (MOB) was determined in sheep. In addition, to establish the origin of adult-born neurons in the MOB, an adeno-associated virus that infects neural cells in the ovine brain was injected into the subventricular zone (SVZ). A migratory stream was indicated from the SVZ up to the MOB, consisting of neuroblasts that formed chain-like structures. Results also showed a long neuronal maturation time in both the DG and the MOB, similar to that in primates. The first new neurons were observed at 1 month in the DG and at 3 months in the MOB after BrdU injections. Thus, maturation of adult-born cells in both the DG and the MOB is much longer than that in rodents and resembles that in nonhuman primates. This study points out the importance of studying the features of adult neurogenesis in models other than rodents, especially for translational research for human cellular therapy.

show abstract

Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors

Cited by 66 publications

References 61 publications

Pregnancy or stress decrease complexity of CA3 pyramidal neurons in the hippocampus of adult female rats

Pregnancy or stress decrease complexity of CA3 pyramidal neurons in the hippocampus of adult female rats

Developmental exposure to SSRIs, in addition to maternal stress, has long-term sex-dependent effects on hippocampal plasticity

Dynamics of olfactory and hippocampal neurogenesis in adult sheep

Contact Info

Product

Resources

About