Stress and its role in the dentin hypersensitivity in rats

Bergamini, Marcelo R.; Kabadayan, Fernanda; Bernardi, Maria Martha; Suffredini, Ivana Barbosa; Ciaramicoli, Márcia Tonetti; Kodama, Ricardo Matsura; Saraceni, Cíntia Helena Coury

doi:10.1016/j.archoralbio.2016.10.007

Cited by 18 publications

(19 citation statements)

References 34 publications

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“…Rats that were treated with acidic solution for 30 days exhibited an increase in dentin hypersensitivity (Bergamini et al, 2014), and restraint stress plus shaking potentiated dentin hypersensitivity (Bergamini et al, 2016). Similar results were observed in the present study.…”

Section: About Dentin Hypersensitivitysupporting

confidence: 91%

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Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats

Barbosa

Cabral

Kabadayan

et al. 2017

Archives of Oral Biology

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Section: About Dentin Hypersensitivitysupporting

confidence: 91%

“…Nociceptive behavioral response that was induced by cold stimuli was consistent with the grade of erosion. Additionally, chronic stress plays an important role in dentin hypersensitivity, reflected by an increase in corticosterone levels, a decrease in body weight, and behavioral data (Bergamini et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats

Barbosa

Cabral

Kabadayan

et al. 2017

Archives of Oral Biology

Self Cite

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“…The open-field test was used for non-motor behavioral activity (Bergamini et al 2017). The elevated plus maze test is one of the most widely used tests for measuring anxiety-like behavior.…”

Section: Methodsmentioning

confidence: 99%

Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

Song

Wang

et al. 2018

Neurotox Res

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A single injection of LPS produced low-grade neuroinflammation leading to Parkinson’s disease (PD) in mice several months later. Whether such a phenomenon occurs in rats and whether such low-grade neuroinflammation would aggravate rotenone (ROT) neurotoxicity and disrupts circadian clock gene/protein expressions were examined in this study. Male rats were given two injections of LPS (2.5–7.5 mg/kg), and neuroinflammation and dopamine neuron loss were evident 3 months later. Seven months after a single LPS (5 mg/kg) injection, rats received low doses of ROT (0.5 mg/kg, sc, 5 times/week for 4 weeks) to examine low-grade neuroinflammation on ROT toxicity. LPS plus ROT produced more pronounced non-motor and motor dysfunctions than LPS or ROT alone in behavioral tests, and decreased mitochondrial complex 1 activity, together with aggravated neuroinflammation and neuron loss. The expressions of clock core genes brain and muscle Arnt-like protein-1 (Bmal1), locomotor output cycles kaput (Clock), and neuronal PAS domain protein-2 (Npas2) were decreased in LPS, ROT and LPS plus ROT groups. The expressions of circadian feedback genes Periods (Per1 and Per2) were also decreased, but Cryptochromes (Cry1 and Cry2) were unaltered. The circadian clock target genes nuclear receptor Rev-Erbα (Nr1d1), and D-box-binding protein (Dbp) expressions were also decreased. Consistent with the transcript levels, circadian clock protein BMAL1, CLOCK, NR1D1 and DBP were also decreased. Thus, LPS-induced chronic low-grade neuroinflammation potentiated ROT neurotoxicity and disrupted circadian clock gene/protein expression, suggesting a role of disrupted circadian in PD development and progression.

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“…These parameters were widely taken as indicative of high-stress state, thus, for the evaluation of levels of emotionality of the animals (Bergamini et al, 2017). For open-field observations, each rat was individually placed on the center of the arena, and its behavioral parameters were recorded for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra

Huang

Zhu

et al. 2017

Front. Mol. Neurosci.

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Parkinson’s disease (PD) is the second most neurodegenerative disorder with a regional decrease of dopamine (DA) neurons in the substantia nigra (SN). Despite intense exploration, the etiology of PD progressive process remains unclear. This study was to investigate the synergistic effects of systemic inflammation of lipopolysaccharide (LPS) and neurotoxicity of rotenone (ROT) on exacerbating DA neuron lesion. Male SD adulthood rats received a single intraperitoneal injection of LPS. Seven months later, rats were subcutaneously given ROT five times a week for consecutive 4 weeks. Rat behavior changes were assessed via rotarod and open-field tests. Brain SN was immunostained to evaluate DA neuronal loss and microglia activation. Striatum DA and its metabolites levels were determined by high performance liquid chromatography (HPLC) coupled with electrochemistry. The protein levels of α-synuclein (α-Syn), inflammatory factors and mitogen-activated protein kinase (MAPK) pathway activation were detected by western blotting analysis. Results indicated that no significant difference between the control and LPS alone groups was shown. Compared with ROT alone group, LPS combined with ROT significantly reduced motor activity and induced SN DA neurons loss accompanied by the decreased contents of striatum DA and its metabolites. Furthermore, LPS together with ROT enhanced microglia activation and the increased expressions of α-Syn and inflammatory factors and also MAPK signaling pathway activation. However, LPS alone had no significant effects on the above parameters. These findings suggest that adulthood exposure to LPS exacerbates the neurotoxic and inflammatory effects of ROT in the SN.

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Stress and its role in the dentin hypersensitivity in rats

Cited by 18 publications

References 34 publications

Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats

Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats

Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra

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