Stress analysis in a layered aortic arch model under pulsatile blood flow

Gao, Feng; Watanabe, Masahiro; Matsuzawa, Teruo

doi:10.1186/1475-925x-5-25

Cited by 92 publications

(45 citation statements)

References 31 publications

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“…Our hypothesis that changes in the media occur in 12-month-old mice in response to high flow pressure generating a mechanical force over the wall of the ascending aortas, is supported by a number of recent papers [11,14]. Phase-contrast MRI and numerical analysis suggest that local wall stress conditions may be the basis for media thickening in the wall of the aortic arches [13].…”

Section: Discussionmentioning

confidence: 58%

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Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria

et al. 2014

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IntroductionA mouse model of progeria derived by insertion of the human mutant LMNA gene (mLMNA), producing mutant lamin A, shows loss of smooth muscle cells in the media of the ascending aorta. We hypothesized that high shear stress, in the presence of mutant lamin A, induces this vasculopathy and tried to define the molecular and cellular basis for aortic vasculopathy.MethodsAscending and descending aortas from wild type (WT) and mLMNA+ mice were compared using proteomics, Western blots, PCR and immunostaining. To determine whether high fluidic shear stress, known to occur in the ascending aorta, contributed to the vasculopathy, we exposed descending aortas of mLMNA+ mice, with no apparent vasculopathy, to 75 dynes/cm2 shear stress for 30 minutes using a microfluidic system.ResultsWhen the mice were one year of age, expression of several mechanotransduction proteins in the ascending aorta, including vimentin, decreased in mLMNA+ mice but no decrease occurred in the descending aorta. High fluidic shear stress produced a significant reduction in vimentin of mLMNA+ mice but not in similarly treated WT mice.ConclusionsThe occurrence of mutant lamin A and high shear stress correlate with a reduction in the level of mechanotransduction proteins in smooth muscle cells of the media. Reduction of these proteins may contribute over time to development of vasculopathy in the ascending aorta in progeria syndrome.

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Section: Discussionmentioning

confidence: 58%

“…Interestingly, the ascending aorta is subjected to the highest fluidic shear stress during each cardiac systole [11-13], with the highest shear stress occurring in the media compared with the intima and adventitia across the aortic wall [11]. …”

Section: Introductionmentioning

confidence: 99%

Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria

et al. 2014

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“…For example, entry tears in type A AD are commonly observed just above the sinotubular junction [5] or aortic isthmus portion, near the top of the arch or just before the innominate artery [9]. However, detailed investigation of the entrance-tear formation in acute aortic syndromes has not been performed.…”

Section: Introductionmentioning

confidence: 99%

Impact of shear stress and atherosclerosis on entrance-tear formation in patients with acute aortic syndromes

et al. 2013

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Weak aortic media layers can lead to intimal tear (IT) in patients with overt aortic dissection (AD), and aortic plaque rupture is thought to progress to penetrating atherosclerotic ulcer (PAU) with intramural hematoma (IMH). However, the influences of shear stress and atherosclerosis on IT and PAU have not been fully examined. Ninety-eight patients with overt AD and 30 patients with IMH and PAU admitted to our hospital from 2002 to 2007 were enrolled. The greater curvatures of the aorta, including the anterior and right portions of the ascending aorta and anterior portion of the aortic arch, were defined as sites of high shear stress. The other portions of the aorta were defined as sites of low shear stress based on anatomic and hydrodynamic theories. Aortic calcified points (ACPs) were manually counted on computed tomography slices of the whole aorta every 10 mm from the top of the arch to the abdominal bifurcation point. IT was more often observed at sites of high shear stress in overt AD than in PAU (73.5 vs 20.0 %, P < 0.0001). Significantly more ACPs were present in PAU than in overt AD (18.6 ± 8 vs 13.3 ± 10, P = 0.007). The present study suggests that high shear stress and less severe atherosclerosis could induce the occurrence of an IT, thereafter progressing to overt AD, and that low shear stress and more severe atherosclerosis could proceed to PAU with IMH. These findings may help to identify the entrance-tear site.

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“…Linear elastic [20,21] and nonlinear elastic material models have been applied so far [6][7][8][9]22]. According to an analysis performed by Holzapfel, the nonlinear elastic approach, referred to as hyperelastic, is closest to reality [13].…”

Section: Vessel With Plaquementioning

confidence: 99%

The effect of stent graft oversizing on radial forces considering nitinol wire behavior and vessel characteristics

Senf

Sachsen²,

Neugebauer

et al. 2014

Medical Engineering & Physics

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Stress analysis in a layered aortic arch model under pulsatile blood flow

Cited by 92 publications

References 31 publications

Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria

Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria

Impact of shear stress and atherosclerosis on entrance-tear formation in patients with acute aortic syndromes

The effect of stent graft oversizing on radial forces considering nitinol wire behavior and vessel characteristics

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