Streptomyces griseus: A new biocatalyst with N-oxygenase activity

Reviewing a plethora of oxidative-type reactions catalyzed by whole cells ofStreptomycesspecies

“…Streptomyces species can convert the amino group to the corresponding nitro groups contributing to the production of nitroaromatic compounds such as nitroaromatic antibiotics like everninomycin. 88,131 A recently published paper has detected an N -oxygenase activity displayed by the whole cells of S. griseus . 88 Based on bioinformatics and experimental analyses, the authors have been able to identify a diiron monooxygenase gene, AurF, from several Streptomyces strains examined.…”

“… 88,131 A recently published paper has detected an N -oxygenase activity displayed by the whole cells of S. griseus . 88 Based on bioinformatics and experimental analyses, the authors have been able to identify a diiron monooxygenase gene, AurF, from several Streptomyces strains examined. The AurF enzyme was previously characterized from another Streptomyces species, S. thioletus .…”

“…Those organisms occupy the natural habitat of S. griseus and therefore act as natural competitors for nutrients, which in turn affect the production of secondary metabolites. 88,133 Co-cultivation of S. griseus with Bacillus cereus , as a stressful organism, at an optimized biomass mixture ratio of 70 : 30 improved the conversion to 45.5% within 4 hours ( Scheme 34 ). 88 …”

“… 88,133 Co-cultivation of S. griseus with Bacillus cereus , as a stressful organism, at an optimized biomass mixture ratio of 70 : 30 improved the conversion to 45.5% within 4 hours ( Scheme 34 ). 88 …”

N-oxygenation of amino compounds: Early stages in its application to the biocatalyzed preparation of bioactive compounds

“…In this sense, systems of two or more bacteria have recently been reported in which their interactions enhance the biosynthetic pathways involved in the synthesis of nitro compounds, leaving the bacteria probably in a resting metabolic state, achieving good yields without engineering intervention (Nóbile et al, 2020).…”