Streptomyces Antibiotics. Xiv. The Position of the Linkage of Streptobiosamine to Streptidine in Streptomycin

Biopesticides: a review of their action, applications and efficacy

“…Streptomycin ( 7 ; Fig 1) was isolated from the soil Actinomycete, Streptomyces griseus (Krainsky) Waksman & Henrici by A Shatz21 in 1944 and its structure was elucidated in 1947 by FA Kuehl Jr et al 22 It was first commercialised by Meiji Seika Kaisha Ltd in Japan as the sesquisulfate. The compound inhibits protein biosynthesis by binding to the 30S ribosomal sub‐unit and causing a mis‐reading of the genetic code in protein biosynthesis 23.…”

Antimycobacterial natural products

“…Aminoglycoside antibiotics, e.g. streptomycin (1), isolated from Streptomyces griseus, 6 and related compound kanamycin 7 and a semi-synthetic analogue amikacin, 8 cyclic peptides, e.g. capreomycin 1A (2) and 1B (3), isolated from Streptomyces capreolus NRRL 2773, 9,10 and viomycin, 11 semisynthetic rifamycin analogues rifampicin (4), rifabutin and rifapentine, 12 and cycloserine (5), 13 are used in combination with other antituberculars as either front-line or second line drugs.…”

“…Although strictly of terpenoid origin, the antimycobacterial activity of (E )-phytol ( 6) is included here due to the structural similarity to other acetogenin-derived metabolites. Investigation of a methanol extract of the Kenyan shrub Leucas volkensii afforded (E )-phytol (6) as the principal antimycobacterial constituent, with an MIC of 2 µg ml Ϫ1 . 38 In an attempt to expand the structure-activity relationship of this finding, the authors also tested semi-synthetic and commercially available analogues 7-17.…”

The Stereoisomerism of Cyclohexane Derivatives.

“…Reaction of streptomycin with benzoyl chloride and pyridine yielded undecabenzoylstreptomycin, from which heptabenzoylstreptidine was obtained (169).…”