Streptococcus pneumoniae Lipoproteins and ABC Transporters

Durmort, Claire; Brown, Jeremy

doi:10.1016/b978-0-12-410530-0.00010-7

Cited by 16 publications

(15 citation statements)

References 79 publications

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“…Both PpmA and SlrA have been shown to promote pneumococcal colonization and contribute to virulence in a mouse model of acute pneumonia . In addition, non‐ABC transporter lipoproteins exert important functions in cell wall biosynthesis and integrity, as demonstrated for the l , d ‐carboxypeptidase DacB (also known as LdcB), as well as stress responses of S. pneumoniae , as recently shown for the extracellular thioredoxin‐like lipoproteins Etrx1 and Etrx2 .…”

Section: A General View On the Role Of Pneumococcal Lipoproteins For mentioning

confidence: 89%

“…However, due to increasingly available structural data, a new classification based on structural similarity has been introduced, now numbering cluster A to F . The in silico analysis predicted up to 37 lipoproteins in S. pneumoniae serotype 2 and 4 according to their Lipobox motif . Recently, a comprehensive proteomic analysis has been performed to elucidate the global surface and exoproteome of S. pneumoniae , including the role of lipoprotein maturation on the protein composition of the bacterial cell envelope and extracellular milieu.…”

Section: Pneumococcal Lipoproteinsmentioning

confidence: 99%

“…The majority of lipoproteins in S. pneumoniae are predicted to be part of ABC importer systems. However, the pneumococcal genome also encodes for several lipoproteins not associated with ABC transporters crucial for bacterial fitness and full virulence (Table ) . For instance, six lipoproteins have been implicated in folding or activation of surface‐exposed proteins, such as the peptidyl‐prolyl isomerases (PPIases) putative proteinase maturation protein A (PpmA) and SlrA, although PPIase activity was only demonstrated for SlrA .…”

Section: A General View On the Role Of Pneumococcal Lipoproteins For mentioning

confidence: 99%

“…Up to 30 ABC transporter‐associated lipoproteins have been predicted in S. pneumoniae and for some, their surface‐localization and impact on bacterial fitness and virulence has been experimentally confirmed or implicated by large‐scale genomic analyses. These include ABC transporter lipoproteins for acquisition of metal ions (e.g., PsaA; AdcA and AdcAII; PiaA, PiuA, and PitA), amino acids and short peptides (MetQ, GlnH; AmiA‐AliA/AliB), sugars (MalX), and inorganic compounds (i.e., PstS) (Table ) . For instance, the three iron‐uptake ABC transporter systems, Pia, Piu, and Pit, are required for bacterial growth and virulence in both pulmonary and systemic models of infection, albeit loss of PiaA, the iron‐binding SBP of Pia, has stronger effects on pneumococcal phenotype than loss of the iron‐binding lipoproteins PiuA and PitA (Table ) .…”

Section: A General View On the Role Of Pneumococcal Lipoproteins For mentioning

confidence: 99%

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Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion

et al. 2016

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Edited by Wilhelm JustStreptococcus pneumoniae (pneumococcus) has evolved sophisticated strategies to survive in several niches within the human body either as a harmless commensal or as a serious pathogen causing a variety of diseases. The dynamic interaction between pneumococci and resident host cells during colonization of the upper respiratory tract and at the site of infection is critical for bacterial survival and the development of disease. Pneumococcal lipoproteins are peripherally anchored membrane proteins and have pivotal roles in bacterial fitness including envelope stability, cell division, nutrient acquisition, signal transduction, transport (as substrate-binding proteins of ABC transporter systems), resistance to oxidative stress and antibiotics, and protein folding. In addition, lipoproteins are directly involved in virulence-associated processes such as adhesion, colonization, and persistence through immune evasion. Conversely, lipoproteins are also targets for the host response both as ligands for toll-like receptors and as targets for acquired antibodies. This review summarizes the multifaceted roles of selected pneumococcal lipoproteins and how this knowledge can be exploited to combat pneumococcal infections.

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Section: A General View On the Role Of Pneumococcal Lipoproteins For mentioning

confidence: 89%

Section: Pneumococcal Lipoproteinsmentioning

confidence: 99%

Section: A General View On the Role Of Pneumococcal Lipoproteins For mentioning

confidence: 99%

Section: A General View On the Role Of Pneumococcal Lipoproteins For mentioning

confidence: 99%

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Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion

et al. 2016

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“…Only a few ABC transporters export toxic agents and antibiotics. Many ABC transporters have important effects on pathogen–host interactions, either by improving bacterial growth in nutrient-restricted conditions, wider effects on bacterial physiology, or by reducing sensitivity to host antimicrobial peptides or to antibiotics (Durmort and Brown, 2015). …”

Section: The Atp-binding Cassette (Abc)mentioning

confidence: 99%

The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy

Saleh²,

et al. 2017

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Over the years chemotherapy failure has been a vital research topic as researchers have been striving to discover reasons behind it. The extensive studies carried out on chemotherapeutic agents confirm that resistance to chemotherapy is a major reason for treatment failure. “Resistance to chemotherapy,” however, is a comprehensive phrase that refers to a variety of different mechanisms in which ATP-binding cassette (ABC) mediated efflux dominates. The ABC is one of the largest gene superfamily of transporters among both eukaryotes and prokaryotes; it represents a variety of genes that code for proteins, which perform countless functions, including drug efflux – a natural process that protects cells from foreign chemicals. Up to date, chemotherapy failure due to ABC drug efflux is an active research topic that continuously provides further evidence on multiple drug resistance (MDR), aiding scientists in tackling and overcoming this issue. This review focuses on drug resistance by ABC efflux transporters in human, viral, parasitic, fungal and bacterial cells and highlights the importance of the MDR permeability glycoprotein being the mutual ABC transporter among all studied organisms. Current developments and future directions to overcome this problem are also discussed.

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Deletion of lacD gene affected stress tolerance and virulence of Streptococcus suis serotype 2

2022

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Streptococcus pneumoniae Lipoproteins and ABC Transporters

Cited by 16 publications

References 79 publications

Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion

Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion

The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy

Deletion of lacD gene affected stress tolerance and virulence of Streptococcus suis serotype 2

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