Streptococcal Pharyngitis Therapy

Stillerman, Maxwell; Isenberg, Henry D.; Moody, Max D.

doi:10.1001/archpedi.1972.02110110085005

Cited by 45 publications

(5 citation statements)

References 10 publications

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“…The aerobic bacteria ranged from 2.2 X lOVmL to 1.5 X lOVmL (mean, 8.6 X lOVmL) in the tonsillar surface and 1.2 X lOVg to 1.3 X lOVg (mean, 6.6 X lOVg) in the tonsillar core. The anaerobic bacteria ranged from 1.2 X lOVmL to 1.1 X lOVmL (mean, 5.6 X lOVmL) in the tonsillar surface and 1.0 X lOVg to 8.0 X lOVg (mean, 4.0 X lOVg) in the tonsillar core.…”

Section: Resultsmentioning

confidence: 98%

Microbiology of Obstructive Tonsillar Hypertrophy and Recurrent Tonsillitis

Kielmovitch¹,

Keleti²,

Bluestone³

et al. 1989

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\A qualitative and quantitative analysis of the tonsillar surface and core of children with recurrent streptococcal tonsillitis and children with obstructive tonsillar hypertrophy was performed. No qualitative difference was found within the two population groups. Haemophilus influenzae and Bacteroides melaninogenicus were the most prevalent \g=b\-lactamase\p=n-\ producing isolates in both groups. Staphylococcus aureus had the highest rate of \g=b\-lactamaseproduction on the tonsillar surface of children with recurrent tonsillitis, while Streptococcus pyogenes was more prevalent in the tonsillar surface cultures of children with obstructive tonsillar hypertrophy. The bacterial density was high but not significantly different in both groups of children. The similar microbial composition and density of both groups and the higher rate of S pyogenes recovery may signify a subclinical disease or normal flora in children with obstructive tonsillar hypertrophy.(Arch Otolaryngol Head Neck Surg.

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Section: Resultsmentioning

confidence: 98%

Microbiology of Obstructive Tonsillar Hypertrophy and Recurrent Tonsillitis

Kielmovitch¹,

Keleti²,

Bluestone³

et al. 1989

Archives of Otolaryngology - Head and Neck Surgery

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“…However, even when much higher doses (up to 4-fold) of penicillin were given, no improved GABHS eradication was achieved. [52][53][54][55][56][57][58][59][60][61][62][63][64] …”

Section: Amoxicillin Shortened Coursementioning

confidence: 99%

Antibacterial Therapy for Acute Group A Streptococcal Pharyngotonsillitis

Brook

2002

Pediatric Drugs

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The objective of this review is to examine the use of short-course antibacterial therapy of group A beta-hemolytic streptococcal (GABHS) pharyngotonsillitis, compared with traditional 10-day therapy. In preparing this paper we reviewed the medical literature of studies comparing 10 days of penicillin with shorter courses of antibacterial therapy. Short-course therapy of 6 days of amoxicillin, 4 to 5 days of cephalosporins, and 5 days of azithromycin was found to be as, or more effective than traditional 10-day penicillin therapy. The benefits of short-course therapy include superior compliance and adherence, lower incidence of adverse effects, less effect on the bacterial flora, improved patient and parent satisfaction, and lower drug costs. In conclusion, short courses of amoxicillin, cephalosporins, and macrolides provide superior or equal efficacy to a 10-day course of penicillin therapy in the treatment of GABHS pharyngotonsillitis.

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“…Since the 1960s, several studies have been published on the failure to eradicate GAS with penicillin. ‘Ping‐pong’ infection as a possible cause of therapeutic failure has been given little attention; its importance in recurrence has been well documented [13,19–21], but also denied [22–24]. Another hypothesis has been established in which there is interference from β ‐lactamase producers in the normal flora of the nasopharynx [25].…”

Section: Discussionmentioning

confidence: 99%