Streptococcal infection distinguishes different types of psoriasis

Weisenseel, Peter; Laumbacher, Barbara; Besgen, Petra; Ludolph-Hauser, Dagmar; Herzinger, Thomas; Roecken, Martin; Wank, Rudolf; Prinz, J. C.

doi:10.1136/jmg.39.10.767

Cited by 59 publications

(51 citation statements)

References 13 publications

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“…According to the recent reports, streptococcal infection and several genetic background have been suggested as a trigger factors of psoriasis exacerbation [13,24]. Based on these results, it has been suggested that therapies targeting the streptococcus can be beneWcial for patients with psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

et al. 2010

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Psoriasis is a relatively common disorder in children and can be triggered by an upper respiratory tract infection. The aim of this study was to compare the clinical features of psoriasis in children and adult. In addition, we evaluated the relationship between anti-streptolysin O (ASO) titers and the clinical features of psoriasis. A total of 30 childhood psoriasis patients and 30 adult psoriasis patients were evaluated. Childhood psoriasis had a facial predominance when compared with the adult psoriasis. The childhood psoriasis patients with high ASO titers had guttate psoriasis more frequently than patients with normal ASO titers. In children with plaque-type psoriasis, psoriasis area and severity index score was increased in the high ASO titer group than normal ASO titer group. In conclusion, if the children with psoriasis show increased ASO titer, the physician should pay attention to the worsening of the psoriasis. Furthermore, early treatment of streptococcal infections might be beneWcial in childhood psoriasis.

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Section: Discussionmentioning

confidence: 99%

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

et al. 2010

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“…The incidence of streptococcal infection in this patient population was analyzed by Weisenseel et al (12); an increased prevalence of streptococcal infection was noted in HLA-Cw6 + patients. However, because of a mean disease duration of 15 y, a direct correlation between psoriasis onset and streptococcal angina was not possible.…”

Section: Ezrin Maspin Prdx2 and Hsp27 Are Particularly Immunogenicmentioning

confidence: 99%

“…Psoriasis onset or relapses are seen in strong association with a prior tonsil infection with group A b-hemolytic streptococci (GAS/Streptococcus pyogenes) (10)(11)(12)(13)(14), and HLA-Cw6 + patients are particularly sensitive to the streptococcal trigger (12,13). The simultaneous presence of the same T cell clones in skin lesions and tonsils in patients with streptococcal-driven psoriasis support a pathogenetic link between streptococcal angina and the lesional psoriatic immune response (15).…”

mentioning

confidence: 99%

Ezrin, Maspin, Peroxiredoxin 2, and Heat Shock Protein 27: Potential Targets of a Streptococcal-Induced Autoimmune Response in Psoriasis

Besgen

Trommler

Vollmer

et al. 2010

The Journal of Immunology

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Psoriasis is an HLA-Cw6–associated T cell-mediated autoimmune disease of the skin that is often triggered by streptococcal angina. To identify keratinocyte proteins, which may become psoriatic autoantigens as the result of an immune response against streptococci, rabbits were immunized with heat-killed Streptococcus pyogenes. Streptococcal immunization induced Ab formation against various human keratinocyte proteins. Sera from psoriasis patients reacted against several of these proteins as well. Common serologic reactivities of rabbits and patients included the proteins ezrin, maspin, peroxiredoxin 2 (PRDX2), heat shock protein (hsp)27, and keratin 6. When used for stimulation of blood lymphocytes, ezrin, maspin, PRDX2, and hsp27 induced increased T cell activation in psoriasis patients, which was particularly evident for HLA-Cw6+ individuals. Ag-specific T cell lines generated with these proteins consisted predominantly of CD8+ T cells and used TCR β-chain rearrangements, which were highly homologous to those expanded within the corresponding skin lesion. Several immunodominant epitopes on the different proteins could be defined according to sequence alignments with the whole genome of S. pyogenes. Our data indicate that maspin, ezrin, PRDX2, hsp27, and potentially keratin 6 could act as autoantigens of a streptococcal-induced autoimmune response and represent targets of the exaggerated T cell response in psoriasis. Additionally, ezrin and hsp27 might constitute antigenic links between psoriasis and inflammatory bowel disease, uveitis, or arteriosclerosis, which are clinically associated.

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“…Disease exacerbation has been associated with skin and/or gut colonization by Staphylococcus aureus, Malassezia and Candida albicans (Noah 1990;Waldman, Gilhar et al 2001). Streptococcal infections precede the development or worsening of psoriasis in more than 90% of patients with type I psoriasis (Weisenseel, Laumbacher et al 2002). The role, if any, of viruses (papilomaviruses, retroviruses, endogenous retroviruses) present in lesional skin is unknown.…”

Section: Triggering Factorsmentioning

confidence: 99%

Psoriasis: Epidemiology, Clinical and Histological Features, Triggering Factors, Assessment of Severity and Psychosocial Aspects

Coimbra¹,

Oliveira²,

Figueiredo³

et al. 2012

Psoriasis - A Systemic Disease

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Streptococcal infection distinguishes different types of psoriasis

Cited by 59 publications

References 13 publications

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers

Ezrin, Maspin, Peroxiredoxin 2, and Heat Shock Protein 27: Potential Targets of a Streptococcal-Induced Autoimmune Response in Psoriasis

Psoriasis: Epidemiology, Clinical and Histological Features, Triggering Factors, Assessment of Severity and Psychosocial Aspects

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