Strengthening health services to control epidemics: empirical evidence from Guinea on its cost‐effectiveness

Damme, Wim Van; Lerberghe, Wim Van

doi:10.1046/j.1365-3156.2003.01189.x

Cited by 18 publications

(5 citation statements)

References 24 publications

(21 reference statements)

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“…ICERs were well above any results reported for previous cholera mass vaccination campaigns [15], [29], [47]–[50]. The main reason why mass vaccination with Dukoral was cost-ineffective in Zanzibar may be due to using an expensive OCV in a relatively low incidence setting.…”

Section: Discussionmentioning

confidence: 53%

Costs of Illness Due to Cholera, Costs of Immunization and Cost-Effectiveness of an Oral Cholera Mass Vaccination Campaign in Zanzibar

Scheffold

Weiss²,

Ali³

et al. 2012

PLoS Negl Trop Dis

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BackgroundThe World Health Organization (WHO) recommends oral cholera vaccines (OCVs) as a supplementary tool to conventional prevention of cholera. Dukoral, a killed whole-cell two-dose OCV, was used in a mass vaccination campaign in 2009 in Zanzibar. Public and private costs of illness (COI) due to endemic cholera and costs of the mass vaccination campaign were estimated to assess the cost-effectiveness of OCV for this particular campaign from both the health care provider and the societal perspective.Methodology/Principal FindingsPublic and private COI were obtained from interviews with local experts, with patients from three outbreaks and from reports and record review. Cost data for the vaccination campaign were collected based on actual expenditure and planned budget data. A static cohort of 50,000 individuals was examined, including herd protection. Primary outcome measures were incremental cost-effectiveness ratios (ICER) per death, per case and per disability-adjusted life-year (DALY) averted. One-way sensitivity and threshold analyses were conducted. The ICER was evaluated with regard to WHO criteria for cost-effectiveness. Base-case ICERs were USD 750,000 per death averted, USD 6,000 per case averted and USD 30,000 per DALY averted, without differences between the health care provider and the societal perspective. Threshold analyses using Shanchol and assuming high incidence and case-fatality rate indicated that the purchase price per course would have to be as low as USD 1.2 to render the mass vaccination campaign cost-effective from a health care provider perspective (societal perspective: USD 1.3).Conclusions/SignificanceBased on empirical and site-specific cost and effectiveness data from Zanzibar, the 2009 mass vaccination campaign was cost-ineffective mainly due to the relatively high OCV purchase price and a relatively low incidence. However, mass vaccination campaigns in Zanzibar to control endemic cholera may meet criteria for cost-effectiveness under certain circumstances, especially in high-incidence areas and at OCV prices below USD 1.3.

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Section: Discussionmentioning

confidence: 53%

Costs of Illness Due to Cholera, Costs of Immunization and Cost-Effectiveness of an Oral Cholera Mass Vaccination Campaign in Zanzibar

Scheffold

Weiss²,

Ali³

et al. 2012

PLoS Negl Trop Dis

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“…Sufficient foresight gleaned from surviving previous epidemics should encourage greater investment in research into this area as a stronger health service offers greater resistance to biological threats as they arise (Van Damme and Van Lerberghe, 2004;Bonneaux and Van Damme, 2006). It is also important to assess whether practitioners are left with post-traumatic effects after dealing with this pandemic, which may affect their resilience during a future epidemic (Tam et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Practitioner experiences in epidemics and pandemics in relation to COVID-19

Hogan

Williams²,

Rees

2020

International Paramedic Practice

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Background: COVID-19 has been declared an international emergency by the World Health Organization. Despite personal concerns, frontline health professionals, such as paramedics, nurses and doctors, continue to treat patients. Ensuring these workers' mental wellbeing is supported during these stressful times is key to their maintaining good mental health in the longer term. Aim: To conduct a review of the literature exploring practitioners' attitudes during a pandemic. Methods: A scoping literature review was conducted to assess information on health professionals' attitudes during COVID-19 and previous pandemics, and to identify their main concerns and whether these were addressed. PubMed, CINAHL, the Cochrane Library and Google Scholar were searched and PRISMA guidelines were followed. Titles and abstracts were screened and emergent themes were identified and discussed. Results: 141 articles were screened; 15 articles were sourced through Google Scholar and reference lists. There were 18 articles in the final sample. There was a lack of published data on COVID-19 at the time of writing. Themes include that health professionals' mental health may be affected during a pandemic. Their biggest concerns are infecting family members and overcoming personal anxieties to continue treating patients. Key themes in protecting staff mental health during a pandemic include increasing their understanding of how to protect themselves and their families, better confidence in personal protective equipment and good managerial communication. Conclusions: Practitioners experience heightened stress levels during pandemics, which may affect their mental health. This has implications for workforce resilience. More research is needed on frontline staff attitudes during the COVID-19 pandemic to protect their mental health.

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“…After our application of all of the exclusion criteria, we identified the 67 analyses summarized in Table that presented results of BCA ( n = 40), CEA ( n = 21), or both ( n = 6) for measles ( n = 45), rubella ( n = 11), or both ( n = 11), which included three analyses identified by references to sources in the gray literature cited by included papers. The first column in Table lists the first author, the publication year, and the citation(s), with multiple citations indicating that we identified more than one paper reporting the analytical results.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions

Thompson

Odahowski²

2014

Risk Analysis

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Economic analyses for vaccine-preventable diseases provide important insights about the value of prevention. We reviewed the literature to identify all of the peer-reviewed, published economic analyses of interventions related to measles and rubella immunization options to assess the different types of analyses performed and characterize key insights. We searched PubMed, the Science Citation Index, and references from relevant articles for studies in English and found 67 analyses that reported primary data and quantitative estimates of benefit-cost or cost-effectiveness analyses for measles and/or rubella immunization interventions. We removed studies that we characterized as cost-minimization analyses from this sample because they generally provide insights that focused on more optimal strategies to achieve the same health outcome. The 67 analyses we included demonstrate the large economic benefits associated with preventing measles and rubella infections using vaccines and the benefit of combining measles and rubella antigens into a formulation that saves the costs associated with injecting the vaccines separately. Despite the importance of population immunity and dynamic viral transmission, most of the analyses used static models to estimate cases prevented and characterize benefits, although the use of dynamic models continues to increase. Many of the analyses focused on characterizing the most significant adverse outcomes (e.g., mortality for measles, congenital rubella syndrome for rubella) and/or only direct costs, and the most complete analyses present data from high-income countries.

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Strengthening health services to control epidemics: empirical evidence from Guinea on its cost‐effectiveness

Cited by 18 publications

References 24 publications

Costs of Illness Due to Cholera, Costs of Immunization and Cost-Effectiveness of an Oral Cholera Mass Vaccination Campaign in Zanzibar

Costs of Illness Due to Cholera, Costs of Immunization and Cost-Effectiveness of an Oral Cholera Mass Vaccination Campaign in Zanzibar

Practitioner experiences in epidemics and pandemics in relation to COVID-19

Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions

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