Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions

Thompson, Kimberly M.; Odahowski, Cassie L.

doi:10.1111/risa.12331

Cited by 25 publications

(26 citation statements)

References 121 publications

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“…Both efficacious and economical, the measles vaccine is also among the safest vaccines used in routine child immunization (Thompson and Odahowski 2014). The vaccine is most commonly administered as a live-attenuated vaccine scheduled for children in the first 2 years of life.…”

Section: Introductionmentioning

confidence: 99%

Trends in childhood measles vaccination highlight socioeconomic inequalities in Vietnam

Kien

Minh

Giang

et al. 2016

Int J Public Health

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ObjectivesTo describe trends in measles vaccine coverage rates and their association with socioeconomic characteristics among children from age 12 to 23 months in Vietnam from the year 2000 to 2014.MethodsData were drawn from the Vietnam Multiple Indicator Cluster Surveys in years 2000, 2006, 2011, and 2014. Concentration indices were used to determine the magnitude of socioeconomic inequalities in measles vaccine coverage. Associations between measles vaccine coverage and relevant social factors were assessed using logistic regression.ResultsSocioeconomic inequalities in measles vaccine coverage rates decreased during 2000–2014. Children belonging to ethnic minority groups, having mothers with lower education, and belonging to the poorest group were less likely to receive measles vaccine; although, their vaccine coverage rates did increase with time. Measles vaccine coverage declined among children of mothers with more education and belonging to the wealthiest socioeconomic group.ConclusionsUnderstanding the social factors influencing adherence to recommend childhood vaccination protocols is essential. Attempts to regain and retain herd immunity must be guided by an understanding of these social factors if they are to succeed.

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Section: Introductionmentioning

confidence: 99%

Trends in childhood measles vaccination highlight socioeconomic inequalities in Vietnam

Kien

Minh

Giang

et al. 2016

Int J Public Health

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“…Thus, international USD 29/DALY were averted in a scenario with 80% coverage and international USD 58/DALY were averted in a scenario with 95% coverage [7]. However, many studies assessing the cost-effectiveness of routine MV were conducted in connection with the introduction of MV in the mid-1980s in low-income countries [31]. Due to declines in measles mortality, the cost-effectiveness estimates in the older studies no longer seem relevant for the present setting.…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness of providing measles vaccination to all children in Guinea-Bissau

Byberg

Fisker

Thysen

et al. 2017

Global Health Action

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Background: Measles vaccination is associated with major reductions in child mortality and morbidity. In Guinea-Bissau, to limit vaccine wastage, children are only measles-vaccinated if at least six children aged 9–11 months are present at a vaccination session.Objective: To estimate the incremental cost-effectiveness of providing measles vaccine (MV) to all children regardless of age and number of children present.Methods: We estimated MV coverage among children living in villages cluster-randomized to MV for all children and among children cluster-randomized to the current restrictive MV policy (status quo). Prices of MV and injection equipment were obtained from the United Nations Children’s Fund (UNICEF). Cost savings of hospital admissions averted were collected from a sample of health facilities. The non-specific mortality effects of MV were estimated and presented as deaths averted and life years gained (LYG) from providing MV-for-all.Results: MV coverage at 36 months was 97% in MV-for-all clusters and 84% in restrictive MV policy clusters. Conservatively assuming 90% wastage of MV under the MV-for-all policy and 40% under the restrictive MV policy, cost per child vaccinated was USD 3.08 and USD 1.19, respectively. The incremental costs per LYG and death averted of the MV-for-all policy were USD 5.61 and USD 148, respectively. The MV-for-all policy became cost-saving at 88% wastage.Conclusions: Taking the low cost of MV and the beneficial non-specific effects of MV into consideration, a 10-dose MV vial should be reclassified as a ‘1+ dose vial’. The vial should be opened for a single child, irrespective of age, but can vaccinate up to 10 children.

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“…, measles control efforts benefit from a strong global surveillance system and the support of the Measles and Rubella Initiative, which provides a forum for the development and coordination of some global activities. Measles represents a relatively inexpensive and highly effective and cost‐effective vaccine, and vaccination represents the primary tool for measles prevention and outbreak control.…”

Section: Extension To Current Vaccinesmentioning

confidence: 99%

Framework for Optimal Global Vaccine Stockpile Design for Vaccine‐Preventable Diseases: Application to Measles and Cholera Vaccines as Contrasting Examples

Thompson

Tebbens²

2014

Risk Analysis

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Managing the dynamics of vaccine supply and demand represents a significant challenge with very high stakes. Insufficient vaccine supplies can necessitate rationing, lead to preventable adverse health outcomes, delay the achievements of elimination or eradication goals, and/or pose reputation risks for public health authorities and/or manufacturers. This article explores the dynamics of global vaccine supply and demand to consider the opportunities to develop and maintain optimal global vaccine stockpiles for universal vaccines, characterized by large global demand (for which we use measles vaccines as an example), and nonuniversal (including new and niche) vaccines (for which we use oral cholera vaccine as an example). We contrast our approach with other vaccine stockpile optimization frameworks previously developed for the United States pediatric vaccine stockpile to address disruptions in supply and global emergency response vaccine stockpiles to provide on-demand vaccines for use in outbreaks. For measles vaccine, we explore the complexity that arises due to different formulations and presentations of vaccines, consideration of rubella, and the context of regional elimination goals. We conclude that global health policy leaders and stakeholders should procure and maintain appropriate global vaccine rotating stocks for measles and rubella vaccine now to support current regional elimination goals, and should probably also do so for other vaccines to help prevent and control endemic or epidemic diseases. This work suggests the need to better model global vaccine supplies to improve efficiency in the vaccine supply chain, ensure adequate supplies to support elimination and eradication initiatives, and support progress toward the goals of the Global Vaccine Action Plan.

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Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions

Cited by 25 publications

References 121 publications

Trends in childhood measles vaccination highlight socioeconomic inequalities in Vietnam

Trends in childhood measles vaccination highlight socioeconomic inequalities in Vietnam

Cost-effectiveness of providing measles vaccination to all children in Guinea-Bissau

Framework for Optimal Global Vaccine Stockpile Design for Vaccine‐Preventable Diseases: Application to Measles and Cholera Vaccines as Contrasting Examples

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