Strengthening global vaccine access for adolescents and adults

Nanni, Angeline; Meredith, S. E. O.; Gati, Stephanie; Holm, Karin; Harmon, Trevor; Ginsberg, Ann M.

doi:10.1016/j.vaccine.2017.10.023

Cited by 19 publications

(15 citation statements)

References 13 publications

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“…Inspection of eqs. (1) and (2) shows that the role of Ag concentration in our model is to shift the selection thresholds by log C. This shift has two different consequences. First, its affects the speed of affinity maturation, that is, the decrease in the population average binding energy per round of evolution.…”

Section: Efficacy Of Affinity Maturation Varies Non Monotonically Witmentioning

confidence: 89%

“…The GC is initialized with N found founder clones from the population of naive 1 This choice of unit is standard in biophysics, and allows one to simply express Boltzmann factors as e − ; in practice, 1 k B T 10 −24 kcal. 2 For example, the dissociation constant K d = 1 µM corresponds to the energy = −13.8, and a tenfold decrease in affinity (with K d varying from 1 µM to 10 µM) corresponds to an increase in binding energy of 2.3.…”

Section: Stochastic Model For Affinity Maturationmentioning

confidence: 99%

“…Vaccines are undoubtedly one of the most effective preventive procedure ever developed and have even been used to eradicate diseases ( Greenwood, 2014 ; Nanni et al, 2017 ). In many cases, vaccine-mediated protection can be directly linked to the generation of an antigen-specific antibody repertoire ( Nakaya et al, 2015 ; Li et al, 2014 ), such as for tetanus toxoid (TT) vaccination ( WHO, 2017 ; Ershler et al, 1982 ).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

Molari

Eyer

Baudry

et al. 2020

eLife

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Affinity maturation is a complex dynamical process allowing the immune system to generate antibodies capable of recognizing antigens. We introduce a model for the evolution of the distribution of affinities across the antibody population in germinal centers. The model is amenable to detailed mathematical analysis and gives insight on the mechanisms through which antigen availability controls the rate of maturation and the expansion of the antibody population. It is also capable, upon maximum-likelihood inference of the parameters, to reproduce accurately the distributions of affinities of IgG-secreting cells we measure in mice immunized against Tetanus Toxoid under largely varying conditions (antigen dosage, delay between injections). Both model and experiments show that the average population affinity depends non-monotonically on the antigen dosage. We show that combining quantitative modeling and statistical inference is a concrete way to investigate biological processes underlying affinity maturation (such as selection permissiveness), hardly accessible through measurements.

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Section: Efficacy Of Affinity Maturation Varies Non Monotonically Witmentioning

confidence: 89%

Section: Stochastic Model For Affinity Maturationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

Molari

Eyer

Baudry

et al. 2020

eLife

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“…Infekcinės ligos yra viena pagrindinių mirties priežasčių visame pasaulyje bei vienas didžiausių sveikatos priežiūros iššūkių XXI amžiuje [1,2]. 2020 metų pradžioje žmoniją užklupo kvėpavimo takų viruso COVID-19 pandemija [3], kuri iš esmės pakoregavo sergamumo gripu (ne mažiau pa-vojinga virusine infekcija) situaciją Lietuvoje.…”

Section: įVadasunclassified

Medicinos Darbuotojų Požiūrio Į Sezoninio Gripo Vakciną Ir Skiepijimosi Elgsenos Sąsajos

Kirvaitienė¹,

Volskienė²,

Vaičiulevičienė³

2021

Health Sciences

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Pasaulio sveikatos organizacija (PSO) skiepytis gripo sezonine vakcina rekomenduoja tiek sveikatos priežiūros įstaigų darbuotojams, tiek pacientams [6]. Lietuvoje sveikatos priežiūros įstaigų darbuotojai kasmet nuo sezoninio gripo skiepijami darbdavio lėšomis, tačiau pasiskiepijusių skaičius Lietuvoje ir pasaulyje išlieka žemas. Tyrimo tikslas – įvertinti sveikatos priežiūros įstaigos medicinos darbuotojų informuotumo apie sezoninio gripo vakciną ir elgsenos, susijusios su skiepijimusi, sąsajas. Anketinėje apklausoje dalyvavo 140 X sveikatos priežiūros įstaigos darbuotojų. Analizuojant apklausos duomenis nustatyta, kad medicinos darbuotojų skiepijimosi elgesys priklauso nuo informuotumo apie sezoninio gripo infekciją ir vakciną, bet skiriasi tarp skirtingų profesijų: dauguma darbuotojų žino apie darbuotojų skiepijimo gripo vakcina tvarką Lietuvoje ir skiepijimo organizavimą jų įstaigoje. Dauguma darbuotojų gavo informacijos iš įstaigos vadovo. Darbuotojai, žinantys apie įstaigoje organizuojamą vakcinaciją nuo gripo, skiepijosi tris kartus dažniau, lyginant su nežinančiais. Kasmet gripo vakcina skiepijosi vidutiniškai keturi iš dešimties darbuotojų: dažniau vyresni nei jaunesni, daugiau moterų nei vyrų, daugiau gydytojų nei kitų profesijų darbuotojų. Du kartus daugiau gydytojų nei slaugytojų rekomendavo pasiskiepyti gripo vakcina šeimos nariams ir pacientams. Siekiant padidinti skiepijimo apimtį, reikėtų daugiau dėmesio skirti darbuotojų informavimui.

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“…Strategies such as national immunization programs have contributed greatly to the increase in life expectancy by reducing the burden of infectious diseases over the last century [4]. Despite these efforts, immunization rates in adolescents and adults remained below recommended targets in many countries [5]. Specifically, the uptake and optimization of maternal immunization-vaccination which protects pregnant women and newborns against vaccine-preventable diseases-deserves special attention [6].…”

Section: Introductionmentioning

confidence: 99%

Health Care Professionals’ Perspectives on Life-Course Immunization: A Qualitative Survey from a European Conference

Philip

Pasquale²

2020

Vaccines

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Today, fewer children die each year from vaccine-preventable diseases than older adults. Health systems need new immunization strategies to tackle the burden of vaccine-preventable disease in an aging society. A life-course immunization (LCI) approach—which entails vaccination throughout an individual’s lifespan—enables adults to age with reduced risk to disease, thereby enabling healthy, active and productive aging. We conducted an audience response system (ARS)-based survey to investigate HCP perspectives on LCI in an opportunistic sample of 222 health care professionals (HCPs) from around the world who attended a European infectious diseases conference. Survey results show that LCI is a priority for HCPs (77.4%–88.6%), with most of them stating the need to frame it as a part of a healthy lifestyle (91.0%–100.0%). Insufficient LCI recommendations by vaccine providers (12.9%–33.3%) and governments (15.2%–41.9%) and insufficient targeted budget allocation (6.1%–21.7%) were indicated as the main barriers to implement LCI, ahead of vaccine hesitancy (9.7%–15.2%). HCPs were willing to make LCI a gateway to healthy aging but need support to work together with other stakeholders involved in the vaccination journey. This could be a step towards equitable health care for all of society.

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Strengthening global vaccine access for adolescents and adults

Cited by 19 publications

References 13 publications

Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

Medicinos Darbuotojų Požiūrio Į Sezoninio Gripo Vakciną Ir Skiepijimosi Elgsenos Sąsajos

Health Care Professionals’ Perspectives on Life-Course Immunization: A Qualitative Survey from a European Conference

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