Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis

Morita, Eishin; Takahashi, Hitoshi; Niihara, Hiroyuki; Dekio, Itaru; Sumikawa, Yasuyuki; Murakami, Yumi; Matsunaka, Hiroshi

doi:10.1111/j.1398-9995.2010.02361.x

Cited by 79 publications

(78 citation statements)

References 17 publications

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“…In line with this, treatment of AD patients by immunotherapy (Bussmann et al, 2007;Kwon et al, 2010), or culture of PBMC with antihistamines (Furukawa et al, 2004;Shoji et al, 2011) leads to a significant reduction of CCL17 expression. Recently, immunofluorescence detection of CCL17 in the skin of AD patients showed that CCL17 expression levels in the stratum corneum correlate with disease activity as well (Morita et al, 2010). As for CCL17, similar findings have been obtained for the other CCR4 ligand CCL22 (Goebeler et al, 2001;Shimada et al, 2004), although CCL17 or CCL22 appear to be expressed by different cell types in the skin as determined by immunohistology (Vestergaard et al, 1999).…”

Section: Ccl17 As a Biomarker For Disease Severity In Adsupporting

confidence: 60%

Expression and Function of CCL17 in Atopic Dermatitis

Stutte¹,

Gerbitzki²,

Novak³

et al. 2012

Atopic Dermatitis - Disease Etiology and Clinical Management

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Section: Ccl17 As a Biomarker For Disease Severity In Adsupporting

confidence: 60%

Expression and Function of CCL17 in Atopic Dermatitis

Stutte¹,

Gerbitzki²,

Novak³

et al. 2012

Atopic Dermatitis - Disease Etiology and Clinical Management

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“…İmmünoreaktif TARC insan ve NC/Nga tipi farelerin atopik dermatit lezyonlarındaki keratinositlerinde eksprese edilmektedir (36) . Ayrıca, atopik dermatitin aktif cilt lezyonlarında bakılan dokusal TARC düzeyi, serum TARC düzeyi ve hastalığın ağırlığı ile orantılı bulunmuştur (37) . Çalışmamızla uyumlu olarak, Kakinuma ve ark.…”

Section: Discussionunclassified

“…TARC derideki keratinositlerden salgılanır ve T hücre kemotaksisini indükler (9) . In vitro çalışmalar, Th2 fenotipindeki lenfositlerin enflamatuvar lezyonlara göçünün TARC tarafından kontrol ettiğini göstermiştir (10) . Ayrıca, TARC integrin bağımlı adhezyonda rol oynar ve trombositleri aktive eder.…”

Section: Introductionunclassified

The relationship between serum TSLP and TARC levels with the severity of atopic dermatitis in infants

Birtekocak¹,

Uysal²,

Karul³

2016

Buch

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ÖZAmaç: Atopik dermatit tanılı sütçocuklarında serum TSLP ve TARC düzeylerinin ölçülmesi, hastalığın ağırlığı ile ilişkisinin araştırılması ve elde edilen sonuçların sağlıklı çocukların değer-leri ile karşılaştırılması amaçlanmıştır. Yöntemler: Atopik dermatitin ağırlığı SCORing atopik dermatitis score (SCORAD) ile belirlendi. Atopik dermatitli çocuklarda atopik durumun değerlendirilmesi için deri prik testi uygulandı. Tüm katılımcılarda serum TSLP ve TARC düzeyi ölçüldü. Bulgular: Atopik dermatitli çocukların serum TSLP ve TARC düzeyleri sağlıklı kontrollerin değerlerinden anlamlı olarak yüksekti (sırasıyla, p=0,001, p=0,004). Atopik dermatitin ağırlığı ile serum TARC düzeyleri arasında ilişki var iken (p=0,014), TSLP ile hastalığın ağırlığı arasın-da ilişki saptanmadı (p=0,80). Atopik dermatitli çocuklarda TSLP ve TARC arasında korrelasyon saptanmaz iken (p=0,576), TARC ile hastanın yaşı arasında negatif yönde orta düzeyde korrelasyon saptandı (r= -0,426, p=0,038). Receiver operating characteristic (ROC) analizinde serum TSLP düzeyinin atopik dermatit varlığını öngörmesi için hesaplanan Eğri Altında Kalan Alan (Area Under Curve, AUC) 0,780 [%95 Güven Aralığı (0,640 -0,885) p<0,001] bulundu. Serum TSLP 30,41 pg/mL düzeyinin atopik dermatit varlığını öngörmede duyarlılığı %72 ve özgüllüğü %84 olarak saptandı. Serum TARC düzeyinin atopik dermatit varlığını öngörmesi için hesaplanan AUC 0,738 [%95 Güven Aralığı (0,595-0,852) p=0,0007] bulundu. Serum TARC 242,68 pg/mL düzeyinin atopik dermatit varlığını öngörmede duyarlılığı %72 ve özgüllüğü %68 bulundu. Sonuç: Serum TSLP ve TARC düzeyleri sütçocuklarında atopik dermatit varlığı ile yakından ilişkilidir. Serum TARC düzeyi atopik dermatit ağırlığı ile ilişkilidir. Anahtar kelimeler: Atopik dermatit, TSLP, TARC ABSTRACTObjective: The aim of the study is to measure serum levels of TSLP and TARC, to evaluate their relationships with disease severity and to compare the results with the levels of healthy children. Methods: The severity of atopic dermatitis was determined by scoring atopic dermatitis score (SCORAD). Skin prick test was performed to evaluate atopic status. Serum TSLP and TARC levels were measured in all participants. Results: Serum levels of TSLP and TARC were significantly higher in children with atopic dermatitis than those of healthy controls (p=0.001, p=0.004, respectively). While, there was an association between disease severity and serum TARC levels (p=0.014), no association was found between TSLP, and severity of disease (p=0.80). There was no correlation between TSLP and TARC (p=0.576), however, TARC was negatively correlated with age of the children with atopic dermatitis (r= -0.426, p=0.038). In receiver operating characteristic (ROC) analysis, area under Curve (AUC) which was calculated serum TSLP level in the prediction of the presence of atopic dermatitis was 0.780 [95% confidence interval (0.640-0.885), p<0.001]. The sensitivity of serum TSLP level of 30,41 pg/mL was 72% and the specificity 84% in the prediction of the presence of atopic der...

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“…The wave-like course of the disease (25) is best evaluated by a series of well-established, physician-related scoring such as the SCORAD (26,27), EASI (28), and more recently by patient-related scorings such as the patientoriented SCORAD (PO-SCORAD) (29). It is expected that besides the clinical scoring, eotaxin (30), TARC (31)(32)(33), and other BMs (18) may be useful to objectively assess the severity of AD. This aspect is crucial for new therapeutic strategies such as the proactive therapy (34,35) or for the development of stratified approaches in the management of AD.…”

Section: Chronic Skin Inflammation and Severitymentioning

confidence: 99%

“…The level of this cytokine in the stratum corneum has been shown to correlate with the severity of AD (32). However, it also seems to be an indicator for the epidermal barrier function and correlates with the transepidermal water loss (TEWL) (112) and may predict the development of AD in infancy when measured in the umbilical cord blood (113).…”

Section: Thymus and Activation-regulated Chemokine (Ccl17/tarc)mentioning

confidence: 99%

Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine

Bieber

2012

Allergy

165

125

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Atopic dermatitis (AD) is a paradigmatic inflammatory chronic skin disease. As for other chronic skin diseases, (i) the spectrum of the clinical phenotype and severity as well as (ii) the genetic background and (iii) the underlying mechanisms strongly suggest a high degree of pathophysiological heterogeneity yet leading to a similar clinical pattern, that is, the eczematous skin lesion, but showing distinct progression patterns. This review suggests to exploit the recent knowledge about AD for a novel approach proposing a tentative first molecular taxonomy of this disease based on the genotype and endophenotype. The consequences in terms of personalized prevention and management are delineated.As an evolution of the biomedical research and our genetic and pathophysiological understanding of complex diseases, we are currently experiencing a new trend in the classification of diseases moving from the purely phenotypic definition to a molecular taxonomy. It is expected that in future medicine, every disease will be characterized by three main groups of information: (i) the genotype, including epigenotypic information, (ii) the endophenotype (1) that comprises all available biomarkers (BMs), and (iii) the clinical phenotype (Fig. 1). Among all chronic inflammatory diseases, atopic dermatitis (AD) represents a paradigmatic condition because of its genetic and pathophysiological complexity (2) and finally the result thereof: the wide spectrum of clinical phenotype (3). This wide spectrum includes at one end the very minor forms such as atopic stigmata or simply dry skin with minimal itching and the erythrodermic and most severe form of AD at the other end. Due to the recent progress in the research of genetic, immunologic, and environmental factors (the so-called exposome) leading to AD, we are just starting to understand the complexity of the mechanisms underlying the variety in the clinical phenotype and to make first attempts to link the genotype and endophenotype to distinct clinical forms and courses of this disease such as the atopic march. After exposing a brief update of the clinical phenotype and pathophysiological aspects, this review introduces the concept of molecular taxonomy for AD and the consequences for its future management in the context of stratified or personalized medicine.

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Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis

Abstract: An immunofluorescent technique combined with tape-stripping was used to measure scTARC. The scTARC can be used as an indicator of the severity of local acute inflammation in patients with AD.

Cited by 79 publications

References 17 publications

Expression and Function of CCL17 in Atopic Dermatitis

Expression and Function of CCL17 in Atopic Dermatitis

The relationship between serum TSLP and TARC levels with the severity of atopic dermatitis in infants

Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine

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