Expression and Function of CCL17 in Atopic Dermatitis

Stutte, Susanne; Gerbitzki, Nancy; Novak, Natalija; Förster, Irmgard

doi:10.5772/25704

Cited by 3 publications

(2 citation statements)

References 149 publications

(193 reference statements)

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“…CCL17 and CCL22 have dual functions, acting as homeostatic as well as inflammatory chemokines 3, 10. In mouse models, CCL17 was shown to promote various allergic and inflammatory diseases, such as contact hypersensitivity (CHS),6, 11 atopic dermatitis (AD),8, 12 inflammatory bowel disease, 13 and atherosclerosis 14 . In humans, CCL17 serves as a biomarker of atopic diseases because serum levels of CCL17 are strongly enhanced in patients suffering from atopic dermatitis, allergic rhinitis, or asthma 15, 16, 17.…”

Section: Introductionmentioning

confidence: 99%

RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo

et al. 2018

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The chemokine CCL17, mainly produced by dendritic cells (DCs) in the immune system, is involved in the pathogenesis of various inflammatory diseases. As a ligand of CCR4, CCL17 induces chemotaxis and facilitates T cell-DC interactions. We report the identification of two novel RNA aptamers, which were validated in vitro and in vivo for their capability to neutralize CCL17. Both aptamers efficiently inhibited the directed migration of the CCR4 lymphoma line BW5147.3 toward CCL17 in a dose-dependent manner. To study the effect of these aptamers in vivo, we used a murine model of contact hypersensitivity. Systemic application of the aptamers significantly prevented ear swelling and T cell infiltration into the ears of sensitized mice after challenge with the contact sensitizer. The results of this proof-of-principle study establish aptamers as potent inhibitors of CCL17-mediated chemotaxis. Potentially, CCL17-specific aptamers may be used therapeutically in humans to treat or prevent allergic and inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo

et al. 2018

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“…In light of the skin barrier defect in AD, it is not surprising that many homeostatic mediators are upregulated, including CCL1, CCL17, and CCL27 (46,127). Once the epidermis becomes leaky, multiple antigens become available to the skin immune system, including bacteria, viruses, and allergens.…”

Section: Chemokine-mediated T Cell Recruitment In Atopic or Allergic Dermatitis Represents Type 2 Diseasementioning

confidence: 99%

T‐cell positioning by chemokines in autoimmune skin diseases

Richmond

Strassner

Essien

et al. 2019

Immunological Reviews

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Autoimmune skin diseases are complex processes in which autoreactive cells must navigate through the skin tissue to find their targets. Regulatory T cells in the skin help to mitigate autoimmune inflammation and may in fact be responsible for the patchy nature of these conditions. In this review, we will discuss chemokines that are important for global recruitment of T cell populations to the skin during disease, as well as signals that fine-tune their localization and function. We will describe prototypical disease responses and chemokine families that mediate these responses. Lastly, we will include an overview of chemokine-targeting drugs that have been tested as new treatment strategies for autoimmune skin diseases.

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