Stratum Corneum Lipids in a Model Structure

Friberg, Stig E.; Suhaimi, Hamdan; Goldsmith, Lisa B.; Rhein, Linda D.

doi:10.1080/01932698808943996

Cited by 19 publications

(6 citation statements)

References 19 publications

(6 reference statements)

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“…3), indicating microcrystals imbedded in a liquid crystalline matrix. The latter was assumed to be a distorted lamellar liquid crystal [14].…”

Section: Resultsmentioning

confidence: 99%

“…At 70°C and 80°C a transformation of the lamellar lipid structure to a disordered structure takes place, originating at 80°C from protein‐associated lipids of the corneocyte envelopes [11–26]. The transition at 100°C is a result of the denaturation of protein and can only be observed when the hydration level of SC is more than 10%[11–24].…”

Section: Discussionmentioning

confidence: 99%

“…The matrix was prepared with reference to the method of Friberg [14], using a sealed 7 mm glass tube with constriction for centrifugation. The lipids and the NaOH solution for the partial neutralization of the fatty acids were weighed into the glass tube and then centrifuged approximately 40 times.…”

Section: Methodsmentioning

confidence: 99%

“…Friberg et al . investigated an artificial mixture of SC lipids, showing that phase behaviour of all components strongly depends on the pH of the mixture [14,15]. Other groups studied SC lipid liposomes and found that membranes prepared with these liposomes had water permeability comparable with the in vivo transepidermal water permeation rate [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of interactions between silicones and stratum corneum lipids

Glombitza

Müller‐Goymann

2001

Intern J of Cosmetic Sci

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Ingredients of topically applied skin care formulations have not only positive effects on the appearance of human skin but can also disturb the Stratum corneum (SC) lipid barrier. In the present study, the influence of silicones (PDMS), as often used cosmetic ingredients, on the microstructure of SC lipids was investigated. For this purpose the interactions of four different PDMS with excised human SC were examined first using differential scanning calorimetry (DSC) and wide angle X-ray diffraction for physical characterization. Because the physical properties of human stratum corneum strongly depend on the lipid composition, showing inter-and intra-individual differences, the interactions with an in vitro model lipid system containing SC fatty acids were also studied, using polarized light microscopy, transmission electron microscopy, small angle X-ray diffraction and DSC. The results revealed that the investigated PDMS do not change either the microstructure of excised human SC or the biphasic lamellar/inverse hexagonal structure of the in vitro model. We concluded that PDMS will not cause any side-effects when topically applied and that our simplified in vitro model could be helpful for estimating interactions between cosmetic ingredients and other topically applied substances and the skin barrier at an early moment of formulation development.

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“…3), indicating microcrystals imbedded in a liquid crystalline matrix. The latter was assumed to be a distorted lamellar liquid crystal [14].…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of interactions between silicones and stratum corneum lipids

Glombitza

Müller‐Goymann

2001

Intern J of Cosmetic Sci

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“…These findings have prompted many work such as Friberg 19 to investigate further. A few model epidermal lipid were formulated based on the characterization of the human stratum corneum [19][20][21] . Initial attempts to form bilayer using the model lipid mixture resulted in a completely heterogenous matrix of liquid fats, undissolved solid, and water 19 .…”

Section: Liquid Crystalmentioning

confidence: 99%

Skin and Liquid Crystal: A brief review on their similarities

Suhaimi¹,

Rose²

2016

Orient. J. Chem

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Looking oneself directly into a mirror and what does one see? The answer is of course one's face. Taking good care of ones skin is synonymous to beauty and healthy life style. However, beauty last only as thick as a skin layer so the saying goes. While, liquid crystal, as the name implies, it looks like a crystal but flow like a liquid. Thus, how does this stucture called liquid crystal relate to skin and beauty? As most of us are aware skin and liquid crystal all around us, be it naturally or in technological applications. Our body body are covered with skin and liquid crystals. Surprise as it may seem but that is a fact, albeit peculiar to some. Classic example of natural liquid crystals are protein and cell membranes, while in industrial application such as electronic devices, for instance, screen of our laptop, digital watches and latest application in cosmeceuticals that is liquid crystal crystal emulsion. The question now arise is how does skin relate to liquid crystal? Why is it that this structure is crucial to the structure and function of skin? How does it relate to the delivery system of active ingredients which is important in many cosmeceuticals product? This paper will provide a brief review on the relationship of these two entities and present some work done in this area of interest. A model for the lipids of the top most layer of the skin namely stratum corneum will be highlighted.

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Neue Pseudoceramide durch Verknüpfung von speziellen Fettstoffen mit Kohlenhydratderivaten

Møller

Knörr²,

Weuthen

et al. 1997

Fett/Lipid

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In den letzten Jahren sind Ceramide zunehmend ins Blickfeld der Lipidforscher gelangt. Nachdem gefunden wurde, daß sie als ein wesentlicher Bestandteil der epidermalen Lipide eine entscheidende Rolle bei der Stabilisierung der Barrierefunktion der Haut spielen, wurden Ceramide weitverbreitet in der Hautkosmetik verwendet. Ihre besondere chemische Struktur und Variabilität sowie ihr Einfluß auf den lamellaren flüssigkristallinen Charakter der Hornschichtlipide und damit auf die Eigenschaften der Hornschicht insgesamt werden angesprochen. Der prinzipielle Aufbau eines Ceramids kann stark vereinfacht als polares nichtionisches Lipid beschrieben werden, dessen amidischer hydrophiler Mittelteil mit zwei unterschiedlich langen Fettresten verbunden ist. Basierend auf diesem Prinzip wurden bereits einige Pseudoceramide hergestellt, die ähnliche Eigenschaften aufweisen wie ihre natürlichen Vorbilder, aber wesentlich preiswerter sind als diese. Relativ neu ist die Verwendung von Kohlenhydratderivaten als hydrophile Gruppe in solchen Pseudoceramiden. Synthese und Eigenschaften einiger typischer Vertreter dieses Typs werden vorgestellt.

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Stratum Corneum Lipids in a Model Structure

Cited by 19 publications

References 19 publications

Investigation of interactions between silicones and stratum corneum lipids

Investigation of interactions between silicones and stratum corneum lipids

Skin and Liquid Crystal: A brief review on their similarities

Neue Pseudoceramide durch Verknüpfung von speziellen Fettstoffen mit Kohlenhydratderivaten

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