Stratum corneum adhesive tape stripping: influence of anatomical site, application pressure, duration and removal

Löffler, Harald; Dreher, Frank; Maibach, Howard I.

doi:10.1111/j.1365-2133.2004.06084.x

Cited by 133 publications

(99 citation statements)

References 47 publications

(62 reference statements)

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“…TS appears to be simple and easy to perform [39][40], however there are different parameters that can influence the quantity of SC removed by a piece of tape, and these include TS mode [38,41], skin hydration, cohesion between cells (which increases with SC's depth), the body site and inter-individual differences [9,42]. The impact of these factors has been frequently investigated [8,[38][39][40][41][42][43][44].…”

Section: Tape Stripping Technique Overviewmentioning

confidence: 99%

“…The determination of the kinetics and penetration depth of different kind of permeants by tracing the concentration profiles in SC, has been facilitated by the use of the virtually non-invasive method of SC stripping with adhesive tape [1,2,5,43,44]. For this reason, TS also offers the possibility of evaluating bioequivalence of topical dermatological dosage forms [5].…”

Section: Applications Of the Tape-stripping Techniquementioning

confidence: 99%

“…Löffler et al [43] investigated the influence of the procedures (anatomical site, pressure, pressure duration, tape removal rate) inherent to each stripping protocol on changes in skin physiology. A significant influence of all parameters on TEWL increase, as a function of tape strip number was observed.…”

Section: ) Evaluation Of Factors That Influence the Physiology Of Thmentioning

confidence: 99%

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The Tape-Stripping Technique as a Method for Drug Quantification in Skin

Merino-Sanjuán²,

et al. 2008

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-Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional investigative techniques.Tape stripping of human stratum corneum is widely used as a method for studying the kinetics and penetration depth of drugs. This paper shows the applications of the tape stripping technique to quantify drug penetration through the skin, underlining its versatile application in the area of topical and transdermal drugs.

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Section: Tape Stripping Technique Overviewmentioning

confidence: 99%

Section: Applications Of the Tape-stripping Techniquementioning

confidence: 99%

Section: ) Evaluation Of Factors That Influence the Physiology Of Thmentioning

confidence: 99%

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The Tape-Stripping Technique as a Method for Drug Quantification in Skin

Merino-Sanjuán²,

et al. 2008

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“…The dry SC was fixed on the glass plate. The native human corneocyte layer was obtained by tapestripping method [8,9]. In this approach, commercially available water-soluble tape (Ultra deep cleansing pore strip, Kao Inc) was put on an inner elbow for 15 min and pulled off.…”

Section: Methodsmentioning

confidence: 99%

“…Glycerin was chosen as a model aqueous solution in this study. Two types of SC were examined, including a multilayered cultured SC and a single-layer native SC (corneocyte) obtained by tape striping method [8,9]. These samples can be obtained without requiring surgery.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of Stratum Corneum in Glycerin Solution by Atomic Force Microscopy

Yanagiya

Takahashi

Goto

2015

e-J. Surf. Sci. Nanotech.

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Stratum corneum (SC), the outermost skin layer, consists of corneocytes and intercellular lipids. In this study, mechanical properties of a cultured human SC and a tape-stripped human corneocyte were examined in a glycerine solution through atomic force microscopy. A multilayered cultured human SC in the low concentration glycerin solution decreased its Young's modulus with time. Besides the corneocyte increased its adhesion force in higher concentration of glycerin solution.

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Skin Impedance Measurements with Nanomesh Electrodes for Monitoring Skin Hydration

Matsukawa

Miyamoto

Yokota

2020

Adv Healthcare Materials

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The importance of continuous monitoring of skin hydration in daily life, to aid in the diagnosis of skin diseases, is rising. Electrodes that can be worn directly on the skin are attracting attention as an effective means. However, they should not inhibit natural water evaporation from the skin and should not cause inflammation or irritation even if they are attached to the body for long periods of time. In this study, nanomesh electrodes that have previously been reported to exhibit high biocompatibility are also found to exhibit high water vapor permeability, resulting in properties that prevent skin dampness. Furthermore, the skin impedance measured using nanomesh electrodes is found to correlate with the hydration level of skin measured using existing medical equipment. This study provides a new approach to measure skin hydration in conditions close to bare skin. Skin is the outermost organ of the body and acts as a barrier separating the inside of the body from the outside world. Skin is essential to prevent the entry of pathogens and contaminants from the outside environment into the body, as well as to prevent excessive evaporation of water from the body. The stratum corneum, the outermost layer of the skin, serves as a barrier that inhibits water evaporation from the skin called trans-epidermal water loss (TEWL). [1] When the stratum corneum is damaged, the water in skin evaporates more easily to the outside world, making the skin prone to dryness. [2] Therefore, it is important to measure the skin hydration levels to assess the barrier function of the stratum corneum. The evaluation of the stratum corneum's barrier function has attracted significant attention from the cosmetic and medical fields as it is useful for understanding the characteristics of an individual's skin and diagnosing skin diseases such as atopic dermatitis, [3] ichthyosis vulgaris, [4] and psoriasis. [5] Skin hydration levels are commonly measured indirectly by measuring the skin's electrical properties, such as the skin impedance and skin capacitance. This is because the higher the hydration level of the skin, the higher the conductivity and dielectric constant. [6,7] In the medical community, the electrical properties of the skin are measured using probes with rigid electrodes

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Stratum corneum adhesive tape stripping: influence of anatomical site, application pressure, duration and removal

Abstract: Tape stripping results are influenced dramatically by all investigated parameters. A dynamic SC stress test to investigate SC cohesion more closely is proposed based on the present observations.

Cited by 133 publications

References 47 publications

The Tape-Stripping Technique as a Method for Drug Quantification in Skin

The Tape-Stripping Technique as a Method for Drug Quantification in Skin

Mechanical Properties of Stratum Corneum in Glycerin Solution by Atomic Force Microscopy

Skin Impedance Measurements with Nanomesh Electrodes for Monitoring Skin Hydration

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