Strategy towards independent electrical stimulation from cochlear implants: Guided auditory neuron growth on topographically modified nanocrystalline diamond

Cai, Yixiao; Edin, Fredrik; Jin, Zhe; Alexsson, Andrei; Gudjonsson, Olafur; Liu, Wei; Rask‐Andersen, Helge; Karlsson, Mikael; Li, Hao

doi:10.1016/j.actbio.2015.11.021

Cited by 31 publications

(29 citation statements)

References 66 publications

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“…Given these limitations, there is lively interest in improving the neural prosthesis interface by directing SGN axon regeneration to approach or even contact the stimulating electrodes (9–17). However, to be effective, such axonal regrowth would need to be highly organized, recapitulating the normal pattern of afferent innervation.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to these biochemical cues, cells respond to topographical features in the environment (31–33). Patterned topographies have emerged as another method to direct cellular patterning such as axon growth (17,34,35). Of particular relevance, recent work demonstrated that neurites from cultured neonatal SGN respond to topographical features that guide neurite growth (36–38).…”

Section: Introductionmentioning

confidence: 99%

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Photopolymerized Microfeatures Guide Adult Spiral Ganglion and Dorsal Root Ganglion Neurite Growth

Xu¹,

Seline²,

Leigh³

et al. 2018

Otology &Amp; Neurotology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photopolymerized Microfeatures Guide Adult Spiral Ganglion and Dorsal Root Ganglion Neurite Growth

Xu¹,

Seline²,

Leigh³

et al. 2018

Otology &Amp; Neurotology

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“…At present, many researchers had paid attention to the biomedical application of diamond film. For example, Cai et al reported the application for the NCD film for the cochlear implants [70]. Human inner ear ganglion neurites and the neural progenitor cell could attach well on the NCD surface.…”

Section: Biocompatible Applicationmentioning

confidence: 99%

Nanocrystalline Diamond Films Grown by Microwave Plasma Chemical Vapor Deposition and Its Biocompatible Property

Yang¹,

Zhang²

2018

AMPC

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Due to its unique properties such as high hardness, light transmittance, thermal conductance, chemical stability and corrosion resistance, diamond has drawn tremendous attention in last two decades. These specific properties made diamond film a promising material for cutting tools, microwave windows, heat sinks for electronic devices and diamond electrodes. However, the diamond film with grain sizes at microscale usually exhibits high surface roughness and hinders its applications in the microelectro mechanical system (MEMS) and biological field because it is difficult to be polished by mechanical and chemical methods. With the development of the chemical vapor deposition, the nanocrystalline diamond (NCD) film has been fabricated and found new applications. The grain size of NCD film is in the range of 10 to 100 nm, which inherits the properties of the diamond and possesses the unique properties of the nanoscale materials, and the morphology of the NCD film is granular or needle-like structure. The microwave plasma chemical vapor deposition (MPCVD) has been regarded as the most promising method to deposit NCD film at low temperature. Compared to the hot filament CVD, MPCVD can grow high quality NCD film avoiding of the contamination from the filament materials. The MPCVD technique has high plasma density to activate carbonaceous compound and grow NCD film in high growth rate and low substrate temperature. The unique properties of NCD film, such as the superior electrical, mechanical and biological properties facilitate their application in various fields. The biological application, especially as a biocompatible coating, mainly includes the joint replacement implants and protective coatings and the ophthalmological prosthesis.

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“…An ideal alternative to these conventional methods is to use small scale sensors as they are considerably less expensive.However, their performance in the field must match that of established analytical instruments in order to gain acceptance. Therefore, nanomaterials as the sensing media/interface offer distinct advantages in their sensitivity and selectivity.Work by Li et al[186] systematically investigated the sensing mechanisms of multiple CNT -based devices for the detection of NH 3 and NO 2 . The authors determined that the interaction between the molecule and the CNTs at the metal -CNT contact was the dominant sensing mechanism at low analyte concentrations.…”

mentioning

confidence: 99%

“…The authors concluded that Brought to you by | University of Gothenburg Authenticated Download Date | 10/11/17 3:18 AMregenerating auditory neurons showed a strong affinity to the nano -crystalline diamond pillars, and the technique could be used for neural guidance and the creation of new neural networks. Together with the unique anti-bacterial and electrical properties of nanocrystalline diamond, patterned surfaces could provide designed neural/electrode interfaces to generate independent electrical stimulation signals in cochlear implant electrode arrays for the neural population[186].…”

mentioning

confidence: 99%

Carbon nanomaterials and their application to electrochemical sensors: a review

Power¹,

Gorey²,

Chandra³

et al. 2018

Nano Online

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Carbon has long been applied as an electrochemical sensing interface owing to its unique electrochemical properties. Moreover, recent advances in material design and synthesis, particularly nanomaterials, has produced robust electrochemical sensing systems that display superior analytical performance. Carbon nanotubes (CNTs) are one of the most extensively studied nanostructures because of their unique properties. In terms of electroanalysis, the ability of CNTs to augment the electrochemical reactivity of important biomolecules and promote electron transfer reactions of proteins is of particular interest. The remarkable sensitivity of CNTs to changes in surface conductivity due to the presence of adsorbates permits their application as highly sensitive nanoscale sensors. CNT-modified electrodes have also demonstrated their utility as anchors for biomolecules such as nucleic acids, and their ability to diminish surface fouling effects. Consequently, CNTs are highly attractive to researchers as a basis for many electrochemical sensors. Similarly, synthetic diamonds electrochemical properties, such as superior chemical inertness and biocompatibility, make it desirable both for (bio) chemical sensing and as the electrochemical interface for biological systems. This is highlighted by the recent development of multiple electrochemical diamond-based biosensors and bio interfaces.Keywords: bio sensors; carbon nanomaterials; carbon nanotubes; electrochemical sensing; synthetic diamond Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.

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Strategy towards independent electrical stimulation from cochlear implants: Guided auditory neuron growth on topographically modified nanocrystalline diamond

Cited by 31 publications

References 66 publications

Photopolymerized Microfeatures Guide Adult Spiral Ganglion and Dorsal Root Ganglion Neurite Growth

Photopolymerized Microfeatures Guide Adult Spiral Ganglion and Dorsal Root Ganglion Neurite Growth

Nanocrystalline Diamond Films Grown by Microwave Plasma Chemical Vapor Deposition and Its Biocompatible Property

Carbon nanomaterials and their application to electrochemical sensors: a review

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