Strategy of Pharmacological Regulation of Intracellular Signal Transduction in Regeneration-Competent Cells

Halogenated (Cl-ion) songorine is a new original agonist of fibroblast growth factor receptors of neuronal-committed progenitors possessing neuroregenerative effect after cerebral ischemia and hypoxia in experimental animals

“…The functional asymmetry was assessed semi-quantitatively according to the width of palpebral fissure on the side of complete stenosis of carotid artery: 0 points -palpebral fissure is completely open; 1 point -palpebral fissure on the left is less by 1/3 compared with the right one; 2 points -palpebral fissure on the left is less than on the right one by 2/3; 3 points -palpebral fissure is completely closed (in the form of a slit); 4 points -palpebral fissure on the left is completely closed. The preservation of conditioned reflex of passive avoidance was examined on the 7th day of the study [1,6,16]. In addition, on the 7th day histological preparations from animals brain were studied.…”

“…Mice with posthypoxic encephalopathy received mSON orally through a catheter at a dose of 15 mcg / kg once a day for 5 days. On the 3rd, 7th, 14th, 21st days, registration of the orienting-research behavior in the open field was carried out and a conditioned reflex of passive avoidance was developed, the safety of which was tested on the 7th, 14th, 21st days of the study [1,6,16]…”

“…Ischemic blood supply disturbances of nervous tissue and other hypoxic states are the most common pathological condition of the central nervous system (CNS). Hypoxia of brain significantly reorganizes the CNS, changes the integrative-starting activity of neurons and leads to the formation of qualitatively new pattern of interaction between individual brain structures, and in the case of de-compensation of adaptation mechanisms, triggers a chain of pathological processes resulting in progressive neurological and cognitive disorders, including the development of encephalopathy [1][2][3][4][5][6]. Pharmacological action of existing neuroprotective agents consists mainly in protection or modulation of functions of mature cells of nervous tissue surviving in the pathology.…”

“…However this concept of pharmacological intervention in some cases is proved to be untenable. Available drugs are often incapable completely to restore the morphofunctional state of brain as well as prevent the development of progredient nature of pathological process in the nervous tissue [1,6,7]. In connection with this, the development of fundamentally new pathogenetically grounded approaches to the treatment of central nervous system diseases and creation of original cerebroprotectors with qualitatively new mechanisms of action are relevant.…”

“…The search for solutions to this problem is being carried out within the framework of regenerative medicine. Rapid development of cellular technology in recent decades allowed to implement significant "breakthrough" in understanding of stem cell (SC) biology and led to the possibility of developing new direction in the treatment of many diseases -cell therapy [1,[6][7][8][9][10][11][12][13]. In this case more physiological and perspective approach to solving the problems of regenerative medicine, including treatment of central nervous system diseases, is considered to be pharmacological stimulation of endogenous SC functions by imitation of the activity of natural regulatory systems [7].…”