Strategy for Securing Key Patents in the Field of Biomaterials

Im, Seung Hyuk; Kim, Hyun-Tak; Lee, Cheol Woo; Jung, Youngmee; Kim, Soo Hyun

doi:10.1007/s13233-020-8033-0

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…This technology has the potential to expand medical coverage and resolve problems, such as a lack of organ donation and transplant rejection [ 65 , 66 , 67 , 68 , 69 ]. Scaffolds that are suitable for tissue engineering require high biocompatibility, biodegradability, good processability, mechanical properties similar to those of native tissue, and proper flexibility [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. sc-PLA has been extensively applied in tissue engineering owing to its excellent biocompatibility, full biodegradability, improved mechanical properties, and thermal stability.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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“…Polylactide (PLA), which is regarded as a promising biodegradable polymer, naturally exists in distinct forms of poly( l -lactide) (PLLA) (levorotatory) and poly( d -lactide) (PDLA) (dextrorotatory) owing to its chirality. − Formation of stereocomplex crystals can be induced between two enantiomers in racemic blends. , Stereocomplex PLA (sc-PLA) can possess significantly improved physical and mechanical properties as well as thermal resistance. Eco-friendly polymeric materials based on sc-PLA can be applied to applications that must endure high external stress and loads. , Stereocomplexation of PLA is commonly induced by solution blending, , melt blending, , and supercritical fluid (SCF) technology. , Our research group has been continuously investigating stereocomplexation for many years. − However, the methods developed thus far have many drawbacks, such as low processability, low yield, low solubility with solvent and solute, high cost, and slow production.…”

Section: Introductionmentioning

confidence: 99%

Strategy for Stereocomplexation of Polylactide Using O/W Emulsion Blending and Applications as Composite Fillers, Drug Carriers, and Self-Nucleating Agents

Park

Jung

et al. 2020

ACS Sustainable Chem. Eng.

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Biodegradable polymer polylactide (PLA) can form stereocomplex crystals through racemic blending between poly(Llactide) (PLLA) and poly(D-lactide) (PDLA). This stereocomplexation could lead to substantially improved mechanical and physical strengths for PLA. Various methods for preparing stereocomplex PLA (sc-PLA) have been studied, e.g., solution blending, melt blending, and supercritical fluid (SCF) technology. However, current methods inevitably have various drawbacks including poor efficiency, usability, and low stereocomplexation reaction speeds. Thus, the aim of this study is to develop a novel strategy using oil-in-water (O/W) emulsion blending to overcome the current limitations of stereocomplexation. Our results indicate that the developed strategy can considerably improve the efficiency and accessibility of stereocomplex crystal formation compared to conventional methods such as solution blending and SCF technology. The O/W emulsion blending method exhibits a stereocomplexation efficiency of up to nearly 99%. Additionally, the sc-PLA produced by O/W emulsion blending can act as filler in PLA composites, leading to improvement of their mechanical properties. In addition, a cancer drug such as fluorouracil (5-FU) could be infiltrated into sc-PLA during stereocomplexation induced by O/W emulsion blending. Furthermore, sc-PLA with 5-FU prepared by the novel method could be added for ISN-polymerization in order to give both a nucleating effect and an anticancer effect. It suggests that sc-PLA prepared by our novel method could act as a stable carrier for secondary molecules as well as nucleating agents.

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