Strategy for anthocyanins production: From efficient green extraction to novel microbial biosynthesis

Yang, Shini; Lu, Man; Wu, Jihong; Liao, Xiaojun; Xu, Zhenzhen

doi:10.1080/10408398.2022.2067117

Cited by 13 publications

(10 citation statements)

References 122 publications

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“…Anthocyanins are widely dispersed in nature and display beautiful colors and many health-promoting benefits; hence, they are frequently utilized in food, pharmaceuticals, and cosmetics [ 12 ]. Figure 2 shows that DR flowers are rich in anthocyanin content, which increases with the concentration of DRPE.…”

Section: Resultsmentioning

confidence: 99%

“…Such advantageous substances enable the use of flowers as pro-vitamin A, a natural source of color, and an ingredient in cosmetics, feed, and meals. Furthermore, anthocyanins are widely dispersed in nature and display beautiful colors and many health-promoting benefits; hence, they are frequently utilized in the food, pharmaceutical, and cosmetic sectors [ 12 ]. The D. regia with red and white flowers indicates the presence of anthocyanins, which are generated from phenol-propaniods such as peonidin-3-O-glucoside, petunidin-3-O-acetyl glucoside, and cyanidin-3-O rutinoside.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Delonix regia Flowers’ Pigment and Polysaccharides: Evaluating Their Antibacterial, Anticancer, and Antioxidant Activities and Their Application as a Natural Colorant and Sweetener in Beverages

et al. 2023

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In the present study, an attempt was made to investigate the in vitro antioxidant, anticancer, and antibacterial activities of Delonix regia, then in vivo evaluate its safety as a natural colorant and sweetener in beverages compared to synthetic colorant and sweetener in rats, then serve the beverages for sensory evaluation. Delonix regia flowers had high protein, polysaccharide, Ca, Na, Mg, K, and Fe contents. The Delonix regia pigment extract (DRPE) polysaccharides were separated and purified by gel permeation chromatography on Sephacryl S-200, characterized by rich polysaccharides (13.6 g/L). The HPLC sugar profile detected the monosaccharides in the extracted polysaccharides, composed of mannose, galactose, glucose, arabinose, and gluconic acid, and the structure of saccharides was confirmed by FTIR, which showed three active groups: carbonyl, hydrocarbon, and hydroxyl. On the other hand, the red pigment constituents of DRPE were detected by HPLC; the main compounds were delphinidin and cyanidin at 15 µg/mL. The DRPE contained a considerable amount (26.33 mg/g) of anthocyanins, phenolic compounds (64.7 mg/g), and flavonoids (10.30 mg/g), thus influencing the antioxidant activity of the DRPE, which scavenged 92% of DPPH free radicals. Additionally, it inhibited the population of pathogenic bacteria, including Staphylococcus aureus, Listeria monocyogenes, Salmonella typhimurum, and Pseudomonas aeruginosa, in the range of 30–90 μg/mL, in addition to inhibiting 85% of pancreatic cancer cell lines. On the in vivo level, the rats that were delivered a diet containing DRPE showed regular liver markers (AST, ALP, and ALT); kidney markers (urea and creatinine); high TP, TA, and GSH; and low MDA, while rats treated with synthetic dye and aspartame showed higher liver and kidney markers; lowered TP, TA, and GSH; and high MDA. After proving the safety of DRPE, it can be safely added to strawberry beverages. Significant sensorial traits, enhanced red color, and taste characterize the strawberry beverages supplemented with DRPE. The lightness and redness of strawberries were enhanced, and the color change ΔE values in DRPE-supplemented beverages ranged from 1.1 to 1.35 compared to 1.69 in controls, indicating the preservative role of DRPE on color. So, including DRPE in food formulation as a natural colorant and sweetener is recommended for preserving health and the environment.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Delonix regia Flowers’ Pigment and Polysaccharides: Evaluating Their Antibacterial, Anticancer, and Antioxidant Activities and Their Application as a Natural Colorant and Sweetener in Beverages

et al. 2023

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“…Increasingly, the food industry is interested in applying mild non-thermal methods of processing in anthocyanin extraction including ultrasound-assisted extraction, pressurised liquid extraction, supercritical fluid extraction, high hydrostatic pressure extraction, pulsed light, pulsed electric field, high-voltage energy discharge extraction, microwave-assisted extraction, enzyme-assisted extraction and instant controlled pressure drop-assisted extraction together with bio-based solvents [ 12 , 15 , 16 , 17 , 18 ].…”

Section: Sources Of Anthocyaninsmentioning

confidence: 99%

Anthocyanins in Chronic Diseases: The Power of Purple

et al. 2022

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Anthocyanins are mainly purple-coloured phenolic compounds of plant origin that as secondary metabolites are important in plant survival. Understanding their health benefits in humans requires sourcing these unstable compounds in sufficient quantities at a reasonable cost, which has led to improved methods of extraction. Dark-coloured fruits, cereals and vegetables are current sources of these compounds. The range of potential sustainable sources is much larger and includes non-commercialised native plants from around the world and agri-waste containing anthocyanins. In the last 5 years, there have been significant advances in developing the therapeutic potential of anthocyanins in chronic human diseases. Anthocyanins exert their beneficial effects through improvements in gut microbiota, oxidative stress and inflammation, and modulation of neuropeptides such as insulin-like growth factor-1. Their health benefits in humans include reduced cognitive decline; protection of organs such as the liver, as well as the cardiovascular system, gastrointestinal tract and kidneys; improvements in bone health and obesity; and regulation of glucose and lipid metabolism. This review summarises some of the sources of anthocyanins and their mechanisms and benefits in the treatment of chronic human diseases.

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“…Thus, anthocyanins with different structures and pharmacological effects must be precisely used according to the treatment goals of different diseases. , Anthocyanin extracts from plants are currently being concentrated for use. Although some advanced techniques are available for anthocyanin extraction, − the following limitations remain: (1) Traditional extraction methods require a large amount of organic solvent, and liquid waste treatment performed after extraction causes environmental pollution, health hazards, and safety risks. , (2) Impurities, such as sugars, organic acids, and proteins, are produced during extraction. A variety of methods and steps are required to separate different anthocyanin monomers. , (3) As the extraction steps and preparation time increase, low extraction rates and unstable chemical properties of products increase. , Therefore, a feasible extraction method that is more efficient and involves less organic solvent, easy extraction, and rapid separation of anthocyanins is urgently needed. − …”

mentioning

confidence: 99%

“…Although some advanced techniques are available for anthocyanin extraction, 9−12 the following limitations remain: (1) Traditional extraction methods require a large amount of organic solvent, and liquid waste treatment performed after extraction causes environmental pollution, health hazards, and safety risks. 13,14 (2) Impurities, such as sugars, organic acids, and proteins, are produced during extraction. A variety of methods and steps are required to separate different anthocyanin monomers.…”

mentioning

confidence: 99%

Selective and Controlled Release Responsive Nanoparticles with Adsorption-Pairing Synergy for Anthocyanin Extraction

Jiang,

Wang,

Lou

et al. 2024

ACS Nano

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Anthocyanins with different structures have different anti-inflammatory and anti-cancer properties. Precise structural use can improve the chemopreventive effects of anthocyanins and enhance treatment outcomes because the anthocyanin structure influences its functional sites and activities. However, owing to the available variety of anthocyanins and their complex structures, the low matching of intermolecular forces between existing adsorbents and anthocyanins limits the targeted separation of anthocyanin monomers. Short-range and efficient selective binding, which is difficult to achieve, is the current focus in the extraction field. We here developed self-assembled Fe 3 O 4based nano adsorbers with different surface modifications based on adsorption-pairing synergy. The electrostatic force, coordination bond, hydrogen bond, and π−π* bond together induced selective adsorption between Fe 3 O 4 nanoparticles and anthocyanin molecules. An acid-release solution disrupted the polarity balance in the aforementioned association system, thereby promoting the controlled release of anthocyanins. Among the candidates, the effects of morphology, particle size, surface charge, and functional group on adsorption performance were analyzed. The polyacrylamide-modified magnetic Fe 3 O 4 nanoparticles were found to be favorable for selectively extracting anthocyanin, with an adsorption capacity of 19.74 ± 0.07 mg g −1 . The release percentage of cyanidin-3-O-glucoside reached up to 98.6% ± 1.4%. This study offers a scientific basis for developing feasible nanotechniques to extract anthocyanins and plant active substances.

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Strategy for anthocyanins production: From efficient green extraction to novel microbial biosynthesis

Cited by 13 publications

References 122 publications

Characterization of Delonix regia Flowers’ Pigment and Polysaccharides: Evaluating Their Antibacterial, Anticancer, and Antioxidant Activities and Their Application as a Natural Colorant and Sweetener in Beverages

Characterization of Delonix regia Flowers’ Pigment and Polysaccharides: Evaluating Their Antibacterial, Anticancer, and Antioxidant Activities and Their Application as a Natural Colorant and Sweetener in Beverages

Anthocyanins in Chronic Diseases: The Power of Purple

Selective and Controlled Release Responsive Nanoparticles with Adsorption-Pairing Synergy for Anthocyanin Extraction

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