Anthocyanins in Chronic Diseases: The Power of Purple

Panchal, Sunil K.; John, Oliver D.; Mathai, Michael L.; Brown, Lindsay

doi:10.3390/nu14102161

Cited by 28 publications

(18 citation statements)

References 277 publications

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“…As aforementioned, anthocyanins increase muscle performance by increasing protein synthesis in muscles. In addition, anthocyanins have a neuroprotective effect by decreasing neuroinflammation and promoting neuronal autophagy to decrease neuronal damage ( 25 ). Therefore, anthocyanins can increase power in vertical jumps increasing performance of muscles and nerves.…”

Section: Resultsmentioning

confidence: 99%

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Lubis,

Dewi,

Supriyan

et al. 2024

Biomed Rep

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Roselle calyces ( Hibiscus sabdariffa L.) is a plant that contains anthocyanin and flavonoids, which function as exogenous antioxidants for the human body to counteract excess oxidative stress. Roselle has anti-hypertensive, anti-cancer and anti-diabetic effects. The present study evaluated roselle to see whether it affects physical fitness. The components of physical fitness include strength, balance, right and left hand grip, vertical jump and VO 2max (maximum oxygen consumption). A total of 30 subjects received 200 ml rosella tea for 30 days every morning and evening. Every week, subjects were assessed for physical fitness. Data analysis used paired t and Wilcoxon test according to the normality test results. The results showed significant improvements in strength (from 24.9 to 27.3 kg; P=0.025), balance (from 23.3 to 42.2 sec; P=0.004), right (from 31.8 to 35.1 kg; P<0.0001) and left hand grip (from 29.8 to 31.6 kg; P=0.020), vertical jump (from 38.6 to 41.1 m/sec; P=0.008) and VO 2max (from 31.1 to 34.3 ml/kg/min; P=0.014). This demonstrated that roselle significantly improved six parameters of physical fitness and may be used as a supplement to improve physical fitness without severe side effects.

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Section: Resultsmentioning

confidence: 99%

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Lubis,

Dewi,

Supriyan

et al. 2024

Biomed Rep

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“…Anthocyanins, present in purple fruits and vegetables, exert their beneficial effects through improvements in oxidative stress, inflammation, gut microbiota, and modulation of neuropeptides. Their health benefits in humans include protection of the cardiovascular system and kidneys, among others [ 111 ].…”

Section: Bioactive and Senolytic Food And Vascular Calcification In Ckdmentioning

confidence: 99%

Food to Prevent Vascular Calcification in Chronic Kidney Disease

Moldovan,

Rusu,

Potra

et al. 2024

Nutrients

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Vascular calcification (VC) is a consequence of chronic kidney disease (CKD) which is of paramount importance regarding the survival of CKD patients. VC is far from being controlled with actual medication; as a result, in recent years, diet modulation has become more compelling. The concept of medical nutritional therapy points out the idea that food may prevent or treat diseases. The aim of this review was to evaluate the influence of food habits and nutritional intervention in the occurrence and progression of VC in CKD. Evidence reports the harmfulness of ultra-processed food, food additives, and animal-based proteins due to the increased intake of high absorbable phosphorus, the scarcity of fibers, and the increased production of uremic toxins. Available data are more supportive of a plant-dominant diet, especially for the impact on gut microbiota composition, which varies significantly depending on VC presence. Magnesium has been shown to prevent VC but only in experimental and small clinical studies. Vitamin K has drawn considerable attention due to its activation of VC inhibitors. There are positive studies; unfortunately, recent trials failed to prove its efficacy in preventing VC. Future research is needed and should aim to transform food into a medical intervention to eliminate VC danger in CKD.

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“…Anthocyanins are phenolic compounds of mainly violet, red, or blue‐colored plants (e.g., black rice, purple corn, blackberries, and Chinese bayberry) that serve as secondary metabolites and play an important role in plant survival (Panchal et al., 2022). Anthocyanins have been broadly found to promote the growth of Bifidobacterium spp.…”

Section: Plant‐derived Bioactive Ingredients and Ckdmentioning

confidence: 99%

The modulation effects of plant‐derived bioactive ingredients on chronic kidney disease: Focus on the gut–kidney axis

et al. 2023

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Chronic kidney disease (CKD) results mainly from diabetes, hypertension, and glomerulonephritis, which can develop into end-stage renal disease and CKD-related complications, thereby causing high morbidity and mortality. This progression is correlated with pathogenic alterations in the gut microbiota that generate uremic toxins, mainly including indoxyl sulfate, p-cresol sulfate, and trimethylamine-N-oxide. The uremic toxins directly or indirectly induce CKD through oxidative stress, inflammatory response, and subsequently renal fibrosis. However, ongoing developments in CKD therapy still lack nutritional guidelines and new pharmacotherapies with significant effects. In this review, we discuss the modulatory effects of plant-derived bioactive ingredients, such as dietary fiber (oligosaccharides and polysaccharides), polyphenols (e.g., curcumin, anthocyanins, catechins, and resveratrol), and peptides, on gut microbiota and CKD particularly from the view of the gut-kidney axis. We believe that a comprehensive understanding of the underlying mechanisms of CKD is necessary to develop new targeted therapy strategies that will benefit the prevention and treatment of CKD.

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Anthocyanins in Chronic Diseases: The Power of Purple

Cited by 28 publications

References 277 publications

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Food to Prevent Vascular Calcification in Chronic Kidney Disease

The modulation effects of plant‐derived bioactive ingredients on chronic kidney disease: Focus on the gut–kidney axis

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